The Regulation of Cell Size
Open accessAbstract
An adult animal consists of cells of vastly different size and activity, but the regulation of cell size remains poorly understood. Recent studies uncovering some of the signaling pathways important for size/growth control, together with the identification of diseases resulting from aberrations in these pathways, have renewed interest in this field. This Review will discuss our current understanding of how a cell sets its size, how it can adapt its size to a changing environment, and how these processes are relevant to human disease.
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From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [37]
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“Indeed, changes in cell size are often observed in pathological conditions such as cancer, with tumor cells frequently being Cell 176, 1083–1097, Febru This is an open access article und smaller and heterogeneous in size (Ginzberg et al., 2015; Lloyd, 2013).”
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- Authors
- Lloyd, A. C.
- Affiliations
- MRC Laboratory for Molecular Cell Biology (GB)
- Corresponding author
- Lloyd, Alison C.
- ORCID
- Lloyd, Alison C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 154
- Issue
- 6
- Pages
- 1194-1205
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1985235104
- Cited by
- 393
- References
- 12
- Citations by year
- 2026: 20 · 2025: 31 · 2024: 36 · 2023: 33 · 2022: 39 · 2021: 35 · 2020: 35 · 2019: 35 · 2018: 39 · 2017: 30 · 2016: 16 · 2015: 19 · 2014: 23 · 2013: 1 · 2012: 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Cancer Research UK (11244)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- cell size control, cell growth regulation, human disease, cell size homeostasis
- MeSH terms
- Animals, Cell Cycle, Homeostasis, Humans, Neoplasms, Organ Size, Signal Transduction, Cell Size, Cell Proliferation
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