Anatomic Demarcation of Cells: Genes to Patterns
Abstract
An organizing principle of the diverse cell types in multicellular organisms is their anatomic location. In turn, anatomic location is patterned by the positional identities of cells along developmental axes. Recent progress in functional genomics and chromatin biology illustrates how cells use specific gene expression programs to encode location. Dynamic chromatin states of key genes, notably the Hox loci, serve as the internal representation in cells of their positional identity within the animal.
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There is evidence for positional identity among VSMCs along the anterior-posterior, dorso-ventral, and right-left axes of the embryo.
“Furthermore, there is evidence for positional identity among VSMCs along the anterior-posterior, dorso-ventral, and right-left axes of the embryo 28-30 .”
From Vascular smooth muscle cells in atherosclerosis (2019) · cites this paper as [29]
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- Authors
- Chang, H. Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Chang, Howard Y.
- ORCID
- Chang, Howard Y.
- Venue
- Science
- Published
- 2009-11-27
- Volume
- 326
- Issue
- 5957
- Pages
- 1206-1207
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085870515
- Cited by
- 45
- References
- 27
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 1
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- cell fate specification, positional identity, Hox genes, chromatin state, transcriptional programs, anatomical location, cell type diversity, chromatin biology
- MeSH terms
- Animals, Cell Differentiation, Chromatin, Genes, Homeobox, Regulatory Sequences, Nucleic Acid, Gene Expression, Homeodomain Proteins, Gene Expression Regulation, Developmental, Gene Expression Profiling
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