The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin–Expressing Cells
Abstract
Dissecting Ephrin-Receptor Interaction: Ephrins are transmembrane proteins that bind ephrin receptors on adjacent cells, leading to propagation of biochemical signals within both cells. Jørgensen et al. (p. 1502 ) devised a way to use differential isotopic labeling to distinguish cells engineered to express either the receptor or the ligand and to monitor bidirectional signaling events by mass spectrometry of the labeled peptides when the cells were mixed together. Signaling networks were constructed, and the information processing by the two interacting cell types was modeled. Changes in signaling within cells expressing just the ligand (ephrin) caused changes in the signal processing during the adjacent cell's response to binding of the ephrin receptor.
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Ong, S.-E., Blagoev, B., Kratchmarova, I., Kristensen, D. B., Steen, H., Pandey, A., & Mann, M. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200025-mcp200 · Cited by 5,574
High-throughput RNAi screening in cultured cells: a user's guide
Echeverri, C. J., & Perrimon, N. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1836 · Cited by 380
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Metadata
- Authors
- Jørgensen, C., Sherman, A., Chen, G. I., Pasculescu, A., Poliakov, A., Hsiung, M., Larsen, B., Wilkinson, D. G., Linding, R., & Pawson, T.
- Venue
- Science
- Published
- 2009-12-11
- Volume
- 326
- Issue
- 5959
- Pages
- 1502-1509
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2169318944
- Cited by
- 226
- References
- 2
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jørgensen, C., Sherman, A., Chen, G. I., Pasculescu, A., Poliakov, A., Hsiung, M., Larsen, B., Wilkinson, D. G., Linding, R., & Pawson, T. (2009). Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin–Expressing Cells. Science. https://doi.org/10.1126/science.1176615
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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