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Channel-Mediated Tonic GABA Release from Glia

Lee, Soojung, Yoon, Bo-Eun, Berglund, Ken, Oh, Soo-Jin, Park, Hyungju, Shin, Hee-Sup, Augustine, George J., Lee, C. Justin·2010·Science

Abstract

Tonic Inhibition: Neuronal inhibition has recently drawn much attention; however, the mechanisms involved in tonic release of and the cellular source of the neurotransmitter involved, γ-aminobutyric acid (GABA), have been difficult to pin down. Lee et al. (p. 790 , published online 23 September) showed that tonic release of GABA in the cerebellum occurs through the Bestrophin 1 anion channel of cerebellar astrocytes and Bergmann glial cells. These results confirm that glia can serve as a source of GABA for tonic inhibition of neurons and provide more evidence for interactions between neurons and glia cells that have implications for our understanding of brain-signaling mechanisms.

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Metadata

Authors
Lee, S., Yoon, B.-E., Berglund, K., Oh, S.-J., Park, H., Shin, H.-S., Augustine, G. J., & Lee, C. J.
Venue
Science
Published
2010-11-05
Volume
330
Issue
6005
Pages
790-796
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2065031748
Cited by
593
References
4
FWCI
14.05
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.