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Channel-Mediated Tonic GABA Release from Glia
Abstract
Tonic Inhibition: Neuronal inhibition has recently drawn much attention; however, the mechanisms involved in tonic release of and the cellular source of the neurotransmitter involved, γ-aminobutyric acid (GABA), have been difficult to pin down. Lee et al. (p. 790 , published online 23 September) showed that tonic release of GABA in the cerebellum occurs through the Bestrophin 1 anion channel of cerebellar astrocytes and Bergmann glial cells. These results confirm that glia can serve as a source of GABA for tonic inhibition of neurons and provide more evidence for interactions between neurons and glia cells that have implications for our understanding of brain-signaling mechanisms.
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Metadata
- Authors
- Lee, S., Yoon, B.-E., Berglund, K., Oh, S.-J., Park, H., Shin, H.-S., Augustine, G. J., & Lee, C. J.
- Venue
- Science
- Published
- 2010-11-05
- Volume
- 330
- Issue
- 6005
- Pages
- 790-796
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065031748
- Cited by
- 593
- References
- 4
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- closed
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