Cited by 163interferon and immune responsesImmune Response and InflammationRNA regulation and disease

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RIGorous Detection: Exposing Virus Through RNA Sensing

Rehwinkel, Jan, Reis e Sousa, Caetano·2010·Science

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Abstract

Virus infection in mammals elicits a variety of defense responses that are initiated by signals from virus-sensing receptors expressed by the host. These receptors include the ubiquitously expressed RIG-I–like receptor (RLR) family of RNA helicases. RLRs are cytoplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of virus presence. Here, we highlight recent progress in understanding how RLRs discriminate between the RNA content of healthy versus virus-infected cells, functioning as accurate sensors of virus invasion.

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Authors: Rehwinkel, J., & Reis e Sousa, C.
Affiliations: Cancer Research UK (GB)
Immunobiology Laboratory, Cancer Research UK (CRUK) London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK.
ORCID: Rehwinkel, Jan
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-01-15
Volume: 327
Issue: 5963
Pages: 284-286
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1185068
OpenAlex: W2006928776
Cited by: 163
References: 19
Citations by year: 2024: 1 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 3 · 2016: 12 · 2015: 9 · 2014: 16 · 2013: 12 · 2012: 12
FWCI: 10.29
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: Cancer Research UK
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: RIG-I-like receptors, RNA sensing, antiviral innate immunity, RNA helicase, virus detection, host-virus interaction, RIG-I, MDA5, LGP2
MeSH terms: DEAD Box Protein 58, Interferon-Induced Helicase, IFIH1, Animals, Humans, Immunity, Innate, Interferons, Nucleic Acid Conformation, RNA Virus Infections, RNA Viruses, RNA, Double-Stranded, RNA, Viral, Viral Proteins, Signal Transduction, Genome, Viral, Protein Structure, Tertiary, Base Pairing, Receptors, Pattern Recognition, DEAD-box RNA Helicases

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RIGorous Detection: Exposing Virus Through RNA Sensing

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