The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Gamete Recognition in Mice Depends on the Cleavage Status of an Egg’s Zona Pellucida Protein
Open accessAbstract
Getting Gametes Together: Despite decades of research, the molecular basis of sperm-egg recognition in mammals remains unresolved. Models in which a glycan ligand in the zona pellucida (ZP) surrounding ovulated eggs binds to a sperm surface receptor have been widely embraced. A more recent model proposes that the cleavage status of a ZP protein, ZP2, renders the structure of the zona matrix either permissive or nonpermissive for sperm binding. Gahlay et al. (p. 216 ) tested predictions of each model by replacing endogenous zona proteins with either a mutant form of ZP2 that could not be cleaved or of ZP3 that lacked O glycan attachment sites. Sperm-egg recognition depended on the cleavage status of ZP2 rather than on glycan ligands released following fertilization.
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Thall, A. D., Malý, P., & Lowe, J. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.37.21437 · Cited by 401
Asano, M., Furukawa, K., Kido, M., Matsumoto, S., Umesaki, Y., Kochibe, N., & Iwakura, Y. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.1850 · Cited by 270
Cited by
Jin, M., Fujiwara, E., Kakiuchi, Y., Okabe, M., Satouh, Y., Baba, S. A., Chiba, K., & Hirohashi, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018202108 · Cited by 422
Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy
Burkart, A. D., Xiong, B., Baibakov, B., Jiménez-Movilla, M., & Dean, J. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201112094 · Cited by 306
Self-citationSperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice
Nozawa, K., Satouh, Y., Fujimoto, T., Oji, A., & Ikawa, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-19497-6 · Cited by 140
ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat
Nishio, S., Emori, C., Wiseman, B., Fahrenkamp, D., Dioguardi, E., Zamora-Caballero, S., Bokhove, M., Han, L., Stsiapanava, A., Algarra, B., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.013 · Cited by 54
Metadata
- Authors
- Gahlay, G., Gauthier, L., Baibakov, B., Epifano, O., & Dean, J.
- Venue
- Science
- Published
- 2010-07-09
- Volume
- 329
- Issue
- 5988
- Pages
- 216-219
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963715731
- Cited by
- 186
- References
- 2
- FWCI
- 17.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Gahlay, G., Gauthier, L., Baibakov, B., Epifano, O., & Dean, J. (2010). Gamete Recognition in Mice Depends on the Cleavage Status of an Egg’s Zona Pellucida Protein. Science. https://doi.org/10.1126/science.1188178
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