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Structure of the Human BK Channel Ca 2+ -Activation Apparatus at 3.0 Å Resolution
Open accessAbstract
BK Channel Cytoplasmic Domain: BK channels are potassium ion channels found on the surface of a variety of cell types that are essential for the regulation of several key physiological processes, including smooth muscle tone and neuronal excitability. BK channels are regulated by both membrane voltage and intracellular Ca 2+ . The channel comprises an integral membrane pore, an integral membrane voltage sensor domain, and a large cytoplasmic region that confers Ca 2+ sensitivity. Now Yuan et al. (p. 182 , published online 27 May; see the Perspective Weyand and Iwata ) have determined the crystal structure of the cytoplasmic domain of the human BK channel. Four cytoplasmic regions form a gating ring at the intracellular membrane surface with four Ca 2+ binding sites on the outer perimeter.
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Cited by
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Ono, Y., & Sorimachi, H. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.08.005 · Cited by 349
Structure of potassium channels
Kuang, Q., Purhonen, P., & Hebert, H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1948-5 · Cited by 291
Molecular Determinants of BK Channel Functional Diversity and Functioning
Latorre, R., Castillo, K., Carrasquel-Ursulaez, W., Sepulveda, R. V., Gonzalez-Nilo, F., Gonzalez, C., & Alvarez, O. (2017) · Physiological Reviews · doi:10.1152/physrev.00001.2016 · Cited by 271
The structure of the KtrAB potassium transporter
Vieira-Pires, R. S., Szollosi, A., & Morais-Cabral, J. H. (2013) · Nature · doi:10.1038/nature12055 · Cited by 109
Regulation of muscle potassium: exercise performance, fatigue and health implications
Lindinger, M. I., & Cairns, S. P. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04546-8 · Cited by 78
Metadata
- Authors
- Yuan, P., Leonetti, M. D., Pico, A. R., Hsiung, Y., & MacKinnon, R.
- Venue
- Science
- Published
- 2010-07-09
- Volume
- 329
- Issue
- 5988
- Pages
- 182-186
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2115676911
- Cited by
- 299
- References
- 0
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Yuan, P., Leonetti, M. D., Pico, A. R., Hsiung, Y., & MacKinnon, R. (2010). Structure of the Human BK Channel Ca 2+ -Activation Apparatus at 3.0 Å Resolution. Science. https://doi.org/10.1126/science.1190414
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
