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Differential Arginylation of Actin Isoforms Is Regulated by Coding Sequence–Dependent Degradation
Open accessAbstract
Making Modifications: Arginylation of β-actin regulates cell motility and the actin cytoskeleton, but how differential arginylation of the two highly similar actin isoforms—β and γ—is achieved in vivo is unclear. Zhang et al. (p. 1534 ; see the Perspective by Weygand-Durasevic and Ibba ) describe a cotranslational mechanism that selectively regulates the arginylation of proteins through degradation and is dependent on the nucleotide coding sequence coupled to the translation speed. The work provides an explanation for the different N-terminal arginylation states of β- and γ-actin in vivo and suggests translation rate affected by nucleotide coding sequence confers different posttranslational states to proteins and selectively regulates protein degradation.
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Protein degradation and protection against misfolded or damaged proteins.
Goldberg, A. L. (2003) · Nature · doi:10.1038/nature02263 · Cited by 2,088
Cited by
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A critical analysis of codon optimization in human therapeutics
Mauro, V. P., & Chappell, S. A. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.09.003 · Cited by 343
β-Actin specifically controls cell growth, migration, and the G-actin pool
Bunnell, T. M., Burbach, B. J., Shimizu, Y., & Ervasti, J. M. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-06-0582 · Cited by 320
A code within the genetic code: codon usage regulates co-translational protein folding
Liu, Y. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00642-6 · Cited by 252
Multiple roles of the coding sequence 5′ end in gene expression regulation
Tuller, T., & Zur, H. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1313 · Cited by 206
Metadata
- Authors
- Zhang, F., Saha, S., Shabalina, S. A., & Kashina, A.
- Venue
- Science
- Published
- 2010-09-17
- Volume
- 329
- Issue
- 5998
- Pages
- 1534-1537
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035557248
- Cited by
- 206
- References
- 1
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, F., Saha, S., Shabalina, S. A., & Kashina, A. (2010). Differential Arginylation of Actin Isoforms Is Regulated by Coding Sequence–Dependent Degradation. Science. https://doi.org/10.1126/science.1191701
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