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Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory
Open accessAbstract
Germinal Center Survival: The humoral immune response, which comprises antibodies secreted by B lymphocytes, is critical for protection against pathogens. In response to infection, B lymphocytes proliferate and differentiate into antibody-producing effector cells. After an infection clears, a small number of cells persist as memory B cells; however, the survival signals that regulate effector and memory B lymphocyte generation are not well understood. To probe this question, Vikstrom et al. (p. 1095 , published online 7 October) deleted prosurvival genes in activated, antigen-specific B cells during a T lymphocyte–dependent immune response in mice. They found that a specific programmed cell death inhibitor, known as Mcl1, was required for the formation of germinal-center B cells (an effector cell population) and memory B cells but not for their maintenance. Dysregulation of the B cell responses mediated by Mcl1 may be a trigger for lymphomagenesis.
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Chen, L., Willis, S. N., Wei, A., Smith, B. J., Fletcher, J. I., Hinds, M. G., Colman, P. M., Day, C. L., Adams, J. M., & Huang, D. C. S. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.12.030 · Cited by 1,816
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Self-citationVictora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
Dynamics of B cells in germinal centres
De Silva, N. S., & Klein, U. (2015) · Nature Reviews Immunology · doi:10.1038/nri3804 · Cited by 1,084
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Self-citationDeciphering the rules of programmed cell death to improve therapy of cancer and other diseases
Strasser, A., Cory, S., & Adams, J. M. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.307 · Cited by 532
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Metadata
- Authors
- Vikstrom, I., Carotta, S., Lüthje, K., Peperzak, V., Jost, P. J., Glaser, S., Busslinger, M., Bouillet, P., Strasser, A., Nutt, S. L., & Tarlinton, D. M.
- Venue
- Science
- Published
- 2010-11-19
- Volume
- 330
- Issue
- 6007
- Pages
- 1095-1099
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070878170
- Cited by
- 215
- References
- 1
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Vikstrom, I., Carotta, S., Lüthje, K., Peperzak, V., Jost, P. J., Glaser, S., Busslinger, M., Bouillet, P., Strasser, A., Nutt, S. L., & Tarlinton, D. M. (2010). Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory. Science. https://doi.org/10.1126/science.1191793
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