Cited by 1,982Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model OrganismsCalcium signaling and nucleotide metabolism

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Autophagy and Metabolism

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Rabinowitz, Joshua D., White, Eileen·2010·Science

DOI 10.1126/science.1193497PMC PMC3010857

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Abstract

Autophagy is a process of self-cannibalization. Cells capture their own cytoplasm and organelles and consume them in lysosomes. The resulting breakdown products are inputs to cellular metabolism, through which they are used to generate energy and to build new proteins and membranes. Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however—cancer cells exploit it to survive in nutrient-poor tumors.

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1 retracted

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Authors: Rabinowitz, J. D., & White, E.
Affiliations: Princeton University (US)
Rutgers, The State University of New Jersey (US)
ORCID: Rabinowitz, Joshua D.
White, Eileen
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-12-03
Volume: 330
Issue: 6009
Pages: 1344-1348
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1193497
PMC: PMC3010857
OpenAlex: W2039607936
Cited by: 1,982
References: 37
Citations by year: 2026: 54 · 2025: 82 · 2024: 97 · 2023: 110 · 2022: 165 · 2021: 175 · 2020: 172 · 2019: 128 · 2018: 108 · 2017: 144 · 2016: 143 · 2015: 132 · 2014: 123 · 2013: 151 · 2012: 120
FWCI: 12.58
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R37CA053370, RC1CA147961, R01CA130893)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: autophagy, cellular metabolism, lysosomal degradation, metabolic homeostasis, starvation, energy production, degenerative diseases, cancer cells
MeSH terms: Animals, Autophagy, Cell Survival, Disease, Energy Metabolism, Homeostasis, Humans, Metabolism, Neoplasms, Phagosomes, Proteins, Starvation, Signal Transduction, TOR Serine-Threonine Kinases

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