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Cited by 285Chromosomal and Genetic VariationsGenomics and Phylogenetic StudiesDevelopmental Biology and Gene Regulation

Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate

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Denoeud, France, Henriet, Simon, Mungpakdee, Sutada, Aury, Jean-Marc, Da Silva, Corinne, Brinkmann, Henner, Mikhaleva, Jana, Olsen, Lisbeth Charlotte +48 more·2010·Science
DOI 10.1126/science.1194167PMC PMC3760481
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Abstract

Ocean Dweller Sequenced: The Tunicates, which include the solitary free-swimming larvaceans that are a major pelagic component of our oceans, are a basal lineage of the chordates. In order to investigate the major evolutionary transition represented by these organisms, Denoeud et al. (p. 1381 , published online 18 November) sequenced the genome of Oikopleura dioica , a chordate placed by phylogeny between vertebrates and amphioxus. Surprisingly, the genome showed little conservation in genome architecture when compared to the genomes of other animals. Furthermore, this highly compacted genome contained intron gains and losses, as well as species-specific gene duplications and losses that may be associated with development. Thus, contrary to popular belief, global similarities of genome architecture from sponges to humans are not essential for the preservation of ancestral morphologies.

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Crossref · 10.1126/science.1194167

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  • Oikopleura dioica has a highly compacted genome and extensive rearrangements that led to a loss of macrosynteny relative to other chordates.

    “the free-swimming marine invertebrate chordate Oikopleura dioica has a highly compacted genome and extensive rearrangements that led to a loss of macrosynteny relative to other chordates (163, 164).”

    From Topological Approaches in Animal Comparative Genomics (2026) · cites this paper as [164]

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Research works printed but not linked: 25

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Authors
Denoeud, F., Henriet, S., Mungpakdee, S., Aury, J.-M., Da Silva, C., Brinkmann, H., Mikhaleva, J., Olsen, L. C., Jubin, C., Cañestro, C., Bouquet, J.-M., Danks, G., Poulain, J., Campsteijn, C., Adamski, M., Cross, I., Yadetie, F., Muffato, M., Louis, A., Butcher, S., Tsagkogeorga, G., Konrad, A., Singh, S., Jensen, M. F., Cong, E. H., Eikeseth-Otteraa, H., Noel, B., Anthouard, V., Porcel, B. M., Kachouri-Lafond, R., Nishino, A., Ugolini, M., Chourrout, P., Nishida, H., Aasland, R., Huzurbazar, S., Westhof, E., Delsuc, F., Lehrach, H., Reinhardt, R., Weissenbach, J., Roy, S. W., Artiguenave, F., Postlethwait, J. H., Manak, J. R., Thompson, E. M., Jaillon, O., Du Pasquier, L., Boudinot, P., Liberles, D. A., Volff, J.-N., Philippe, H., Lenhard, B., Crollius, H. R., Wincker, P., & Chourrout, D.
Affiliations
  • Commissariat à l’Énergie Atomique, Institut de Génomique, Genoscope, Evry, France.
  • University of Bergen (NO)
  • Centre National de la Recherche Scientifique (FR)
  • Université de Montréal (CA)
  • Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway.
  • University of Oregon (US)
  • Universidad de Cádiz (ES)
  • University of Iowa (US)
  • University of Wyoming (US)
  • Institut de Biologie Cellulaire et Moléculaire du CNRS, Université de Strasbourg, Strasbourg, France.
  • The University of Osaka (JP)
  • Centre Hospitalier d'Albi (FR)
  • Max Planck Institute for Molecular Genetics (DE)
  • National Institutes of Health (US)
  • Institute of Zoology and Evolutionary Biology, University of Basel, Basel, Switzerland.
  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
  • Lyon 1 Université (FR)
Corresponding author
  • Henriet, Simon
  • Mungpakdee, Sutada
  • Aury, Jean-Marc
  • Wincker, Patrick
  • Chourrout, Daniel
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2010-12-03
Volume
330
Issue
6009
Pages
1381-1385
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1194167
PMC
PMC3760481
OpenAlex
W2018991353
Cited by
285
References
3
Citations by year
2026: 7 · 2025: 8 · 2024: 14 · 2023: 10 · 2022: 10 · 2021: 20 · 2020: 16 · 2019: 17 · 2018: 20 · 2017: 13 · 2016: 28 · 2015: 24 · 2014: 29 · 2013: 19 · 2012: 21
FWCI
24.60
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
  • HAL (submittedVersion, other-oa)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • ANU Open Research (Australian National University) (submittedVersion)
Funders
  • National Institutes of Health
  • U.S. National Library of Medicine (Z01LM000073)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
Oikopleura dioica, genome organization, genome plasticity, chordate evolution, pelagic tunicates, intron gain and loss, gene duplication, gene loss, genome compaction, larvaceans
MeSH terms
Animals, DNA Transposable Elements, Biological Evolution, Exons, Genes, Homeobox, Introns, Invertebrates, Molecular Sequence Data, Recombination, Genetic, Urochordata, Vertebrates, Genome, Spliceosomes, Genes, Duplicate, DNA, Intergenic, Gene Order, Synteny

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