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Cited by 1,121

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?

Open access
Lee, Yun Kyung, Mazmanian, Sarkis K.·2010·Science

Abstract

A Gutsy Analysis: Efforts to sequence the human microbiome—the genomes of all the microbes that inhabit our bodies—have demonstrated its enormous diversity. Analyses to probe the various functions of the microbiota, particularly of those that reside in the gut, have revealed that our microbiota has a profound impact on the development and function of our immune systems. Lee and Mazmanian (p. 1768 ) review how the microbiota influences the development of the adaptive immune system. Specific species and families of microbiota support the differentiation of particular populations of T cells, and alterations in intestinal microbiota affect the development of inflammation and autoimmunity.

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Research works printed but not linked: 3

  1. 10.1038/nature06244 · DOI · Paper page
  2. Atarashi K., et al.., Science 10.1126/science.1198469 (2010). · DOI · Paper page
  3. 10.1073/pnas.0804812105 · DOI · Paper page

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Metadata

Authors
Lee, Y. K., & Mazmanian, S. K.
Venue
Science
Published
2010-12-24
Volume
330
Issue
6012
Pages
1768-1773
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1972505691
Cited by
1,121
References
61
FWCI
29.54
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System? https://app.cochat.ai/papers/10.1126/science.1195568
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Lee, Y. K., & Mazmanian, S. K. (2010). Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System? Science. https://doi.org/10.1126/science.1195568

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