The Heritability Hang-Up: The role of variance analysis in human genetics is discussed.
Abstract
http://dx.doi.org/10.1126/science.1198102
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Many of the pre-genomic-era limitations on the use of heritability to make inferences about the genetic basis of phenotypic differences among populations continue to apply, in updated form, to polygenic scores.
“Although estimates of the contributions of specific genetic variants advance modern analyses beyond classical heritability statistics, many of the pre-genomic-era limitations on the use of heritability to make inferences about the genetic basis of phenotypic differences among populations [26–28] continue to apply, in updated form (Fig. 1).”
From Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences (2019) · cites this paper as [27]
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“differences among populations [26-28] continue to apply, in updated form (Fig.”
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- Authors
- Feldman, M. W., & Lewontin, R. C.
- ORCID
- Feldman, M. W.
- Venue
- Science
- Published
- 1975-12-19
- Volume
- 190
- Issue
- 4220
- Pages
- 1163-1168
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978498418
- Semantic Scholar
- 454b41d9d10334b22dab30a565b72cd336ce4113
- Cited by
- 376
- References
- 19
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 18 · 2021: 8 · 2020: 26 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 4 · 2013: 9 · 2012: 5
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- heritability, genetic factors, environmental factors, gene-environment interaction, twin studies
- MeSH terms
- Analysis of Variance, Environment, Genotype, Humans, Intelligence, Metabolism, Inborn Errors, Models, Biological, Phenotype, Genetic Variation
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