Cited by 2,824Immune Cell Function and InteractionReproductive System and PregnancyImmune cells in cancer

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Innate or Adaptive Immunity? The Example of Natural Killer Cells

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Vivier, Eric, Raulet, David H., Moretta, Alessandro, Caligiuri, Michael A., Zitvogel, Laurence, Lanier, Lewis L., Yokoyama, Wayne M., Ugolini, Sophie·2011·Science

DOI 10.1126/science.1198687PMC PMC3089969

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Abstract

Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK cells has emerged. NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development. Moreover, NK cells do not react in an invariant manner but rather adapt to their environment. Finally, recent studies have unveiled that NK cells can also mount a form of antigen-specific immunologic memory. NK cells thus exert sophisticated biological functions that are attributes of both innate and adaptive immunity, blurring the functional borders between these two arms of the immune response.

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Authors: Vivier, E., Raulet, D. H., Moretta, A., Caligiuri, M. A., Zitvogel, L., Lanier, L. L., Yokoyama, W. M., & Ugolini, S.
Affiliations: Centre d’Immunologie de Marseille-Luminy (CIML), Université de la Méditerranée UM 631, Campus de Luminy, 13288 Marseille, France.
University of California, Berkeley (US)
University of Genoa (IT)
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
Inserm (FR)
University of California, San Francisco (US)
Howard Hughes Medical Institute (US)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Raulet, David H.
Moretta, Alessandro
Caligiuri, Michael A.
Zitvogel, Laurence
Lanier, Lewis L.
Yokoyama, Wayne M.
Ugolini, Sophie
ORCID: Raulet, David H.
Caligiuri, Michael A.
Zitvogel, Laurence
Lanier, Lewis L.
Yokoyama, Wayne M.
Ugolini, Sophie
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2011-01-07
Volume: 331
Issue: 6013
Pages: 44-49
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1198687
PMC: PMC3089969
OpenAlex: W2146313292
Cited by: 2,824
References: 78
Citations by year: 2026: 133 · 2025: 147 · 2024: 158 · 2023: 142 · 2022: 215 · 2021: 211 · 2020: 222 · 2019: 205 · 2018: 176 · 2017: 211 · 2016: 176 · 2015: 191 · 2014: 199 · 2013: 200 · 2012: 150
FWCI: 17.62
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Cancer Institute (R01CA093678, R01CA095137, P01CA095426, CA095137, CA16058, CA 68458, CA95426, CA093678, P30CA016058)
National Institute of Allergy and Infectious Diseases (AI-068129, R01AI068129, AI51345, R37AI066897, AI039642, AI34385, R01AI033903, AI5716, R01AI051345, AI-33903, R01AI039642, AI066897, R01AI035021, AI035021, P30AI027763)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: natural killer cells, innate immunity, adaptive immunity, NK cell receptors, activating and inhibitory receptors, self-tolerance, cytotoxicity, viral infection, antitumor immunity, immunological memory
MeSH terms: Animals, Humans, Immunity, Innate, Immunologic Memory, Killer Cells, Natural, Neoplasms, Receptors, Immunologic, Virus Diseases, Self Tolerance, Adaptive Immunity

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Innate or Adaptive Immunity? The Example of Natural Killer Cells

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