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Innate or Adaptive Immunity? The Example of Natural Killer Cells
Open accessAbstract
Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK cells has emerged. NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development. Moreover, NK cells do not react in an invariant manner but rather adapt to their environment. Finally, recent studies have unveiled that NK cells can also mount a form of antigen-specific immunologic memory. NK cells thus exert sophisticated biological functions that are attributes of both innate and adaptive immunity, blurring the functional borders between these two arms of the immune response.
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“Depending on the ligands expressed by the tumor cells studied, different NK-activating receptors may be engaged and trigger cytotoxicity (Vivier et al., 2011).”
From p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells (2013) · cites this paper as Vivier et al., 2011
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“Further analysis showed that the translocation of E. hirae to secondary lymphoid organs could exert an adjuvant impact on systemic and local immune responses mediated by CTX [2].”
From Gut microbiota-mediated immunomodulation in tumor (2021) · cites this paper as [2]
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Metadata
- Authors
- Vivier, E., Raulet, D. H., Moretta, A., Caligiuri, M. A., Zitvogel, L., Lanier, L. L., Yokoyama, W. M., & Ugolini, S.
- Affiliations
- Centre d’Immunologie de Marseille-Luminy (CIML), Université de la Méditerranée UM 631, Campus de Luminy, 13288 Marseille, France.
- University of California, Berkeley (US)
- University of Genoa (IT)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Inserm (FR)
- University of California, San Francisco (US)
- Howard Hughes Medical Institute (US)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Raulet, David H.
- Moretta, Alessandro
- Caligiuri, Michael A.
- Zitvogel, Laurence
- Lanier, Lewis L.
- Yokoyama, Wayne M.
- Ugolini, Sophie
- ORCID
- Venue
- Science
- Published
- 2011-01-07
- Volume
- 331
- Issue
- 6013
- Pages
- 44-49
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3089969
- OpenAlex
- W2146313292
- Cited by
- 2,824
- References
- 78
- Citations by year
- 2026: 133 · 2025: 147 · 2024: 158 · 2023: 142 · 2022: 215 · 2021: 211 · 2020: 222 · 2019: 205 · 2018: 176 · 2017: 211 · 2016: 176 · 2015: 191 · 2014: 199 · 2013: 200 · 2012: 150
- FWCI
- 17.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Cancer Institute (R01CA093678, R01CA095137, P01CA095426, CA095137, CA16058, CA 68458, CA95426, CA093678, P30CA016058)
- National Institute of Allergy and Infectious Diseases (AI-068129, R01AI068129, AI51345, R37AI066897, AI039642, AI34385, R01AI033903, AI5716, R01AI051345, AI-33903, R01AI039642, AI066897, R01AI035021, AI035021, P30AI027763)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- natural killer cells, innate immunity, adaptive immunity, NK cell receptors, activating and inhibitory receptors, self-tolerance, cytotoxicity, viral infection, antitumor immunity, immunological memory
- MeSH terms
- Animals, Humans, Immunity, Innate, Immunologic Memory, Killer Cells, Natural, Neoplasms, Receptors, Immunologic, Virus Diseases, Self Tolerance, Adaptive Immunity
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