The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information
Open accessAbstract
The spatial and temporal organization of molecules within a cell is critical for coordinating the many distinct activities carried out by the cell. In an increasing number of biological signaling processes, scaffold proteins have been found to play a central role in physically assembling the relevant molecular components. Although most scaffolds use a simple tethering mechanism to increase the efficiency of interaction between individual partner molecules, these proteins can also exert complex allosteric control over their partners and are themselves the target of regulation. Scaffold proteins offer a simple, flexible strategy for regulating selectivity in pathways, shaping output behaviors, and achieving new responses from preexisting signaling components. As a result, scaffold proteins have been exploited by evolution, pathogens, and cellular engineers to reshape cellular behavior.
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Self-citationMEK1 and MEK2 inhibitors and cancer therapy: the long and winding road
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Metadata
- Authors
- Good, M. C., Zalatan, J. G., & Lim, W. A.
- Venue
- Science
- Published
- 2011-05-06
- Volume
- 332
- Issue
- 6030
- Pages
- 680-686
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2102424174
- Cited by
- 885
- References
- 4
- FWCI
- 26.92
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
