A Family of IFN-γ–Inducible 65-kD GTPases Protects Against Bacterial Infection

Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

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Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

MacMicking, J. D., Taylor, G. A., & McKinney, J. D. (2003) · Science · doi:10.1126/science.1088063 · Cited by 685

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

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p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

Itakura, E., & Mizushima, N. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201009067 · Cited by 430

Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis

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Inborn errors of interferon (IFN)‐mediated immunity in humans: insights into the respective roles of IFN‐α/β, IFN‐γ, and IFN‐λ in host defense

Zhang, S., Boisson‐Dupuis, S., Chapgier, A. L. A., Yang, K., Bustamante, J. C., Puel, A., Pïcard, C., Abel, L., Jouanguy, E., & Casanova, J. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00698.x · Cited by 334

Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

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Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy

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Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties

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The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage

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Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease

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Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

Singh, S., Ornatowski, W., Vergne, I., Naylor, J., Delgado, M. A., Roberts, E. A., Ponpuak, M., Master, S. S., Pilli, M., White, E., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2119 · Cited by 268

Extensive Characterization of IFN-Induced GTPases mGBP1 to mGBP10 Involved in Host Defense

Degrandi, D., Konermann, C., Beuter-Gunia, C., Kresse, A., Wuerthner, J., Kurig, S., Beer, S., & Pfeffer, K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7729 · Cited by 209

The Interferon-Inducible GTPases

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In Silico Genomic Analysis of the Human and Murine Guanylate-Binding Protein (GBP) Gene Clusters

Olszewski, M. A., Gray, J. C., & Vestal, D. J. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.328 · Cited by 160

Antiviral effects of the interferon‐induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein†

Itsui, Y., Sakamoto, N., Kakinuma, S., Nakagawa, M., Sekine‐Osajima, Y., Tasaka‐Fujita, M., Nishimura‐Sakurai, Y., Suda, G., Karakama, Y., Mishima, K., et al. (2009) · Hepatology · doi:10.1002/hep.23195 · Cited by 159

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii

Hunn, J. P., Könen‐Waisman, S., Papic, N., Schroëder, N., Pawlowski, N., Lange, R., Kaiser, F., Zerrahn, J., Martens, S., & Howard, J. C. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.176 · Cited by 157

Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P2 and PtdIns(3,4,5)P3 promotes immunity to mycobacteria

Tiwari, S., Choi, H.-P., Matsuzawa, T., Pypaert, M., & MacMicking, J. D. (2009) · Nature Immunology · doi:10.1038/ni.1759 · Cited by 133

Human Guanylate Binding Proteins Potentiate the Anti-Chlamydia Effects of Interferon-γ

Tietzel, I., El-Haibi, C. P., & Carabeo, R. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006499 · Cited by 104

ESCRT factors restrict mycobacterial growth

Philips, J. A., Porto, M., Wang, H., Rubin, E. J., & Perrimon, N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707206105 · Cited by 89

Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-γ-inducible cofactor

Modiano, N., Lu, Y. E., & Cresswell, P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503227102 · Cited by 76

Induction of Guanylate Binding Protein 5 by Gamma Interferon Increases Susceptibility toSalmonella entericaSerovar Typhimurium-Induced Pyroptosis in RAW 264.7 Cells

Rupper, A. C., & Cardelli, J. A. (2008) · Infection and Immunity · doi:10.1128/iai.01437-07 · Cited by 52

Autophagy in infection, inflammation and immunity

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Pathways of Antigen Processing

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Macrophage defense mechanisms against intracellular bacteria

Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989

Dynamin, a membrane-remodelling GTPase

Ferguson, S. M., & Camilli, P. V. D. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3266 · Cited by 1,027

Interferon-gamma (IFN-γ): Exploring its implications in infectious diseases

Kak, G., Raza, M., & Tiwari, B. K. (2018) · BioMolecular Concepts · doi:10.1515/bmc-2018-0007 · Cited by 640

This Week in Science

(2011) · Science · doi:10.1126/science.2011.332.6030.twis

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

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Extensive Characterization of IFN-Induced GTPases mGBP1 to mGBP10 Involved in Host Defense

Degrandi, D., Konermann, C., Beuter-Gunia, C., Kresse, A., Wuerthner, J., Kurig, S., Beer, S., & Pfeffer, K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7729 · Cited by 209

ID: 165

Pfeffer, K., Degrandi, D., & Kravets, E. (2015) · Cytokine · doi:10.1016/j.cyto.2015.08.036

IFN-Inducible GTPases in Host Cell Defense

Kim, B.-H., Shenoy, A. R., Kumar, P., Bradfield, C. J., & MacMicking, J. D. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.09.007 · Cited by 287