Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605 · see citing works

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347 · see citing works

Autophagy in Health and Disease: A Double-Edged Sword

Shintani, T., & Klionsky, D. J. (2004) · Science · doi:10.1126/science.1099993 · Cited by 2,532 · see citing works

Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252 · see citing works

Autophagy Defends Cells Against Invading Group A Streptococcus

Nakagawa, I., Amano, A., Mizushima, N., Yamamoto, A., Yamaguchi, H., Kamimoto, T., Nara, A., Funao, J., Nakata, M., Tsuda, K., et al. (2004) · Science · doi:10.1126/science.1103966 · Cited by 1,091 · see citing works

Autophagy Regulates Programmed Cell Death during the Plant Innate Immune Response

Liu, Y., Schiff, M., Czymmek, K. J., Tallóczy, Z., Levine, B., & Dinesh‐Kumar, S. P. (2005) · Cell · doi:10.1016/j.cell.2005.03.007 · Cited by 865 · see citing works

Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy

Paludan, C., Schmid, D., Landthaler, M., Vockerodt, M., Kube, D., Tuschl, T., & Münz, C. (2005) · Science · doi:10.1126/science.1104904 · Cited by 860 · see citing works

Escape of Intracellular Shigella from Autophagy

Ogawa, M., Yoshimori, T., Suzuki, T., Sagara, H., Mizushima, N., & Sasakawa, C. (2004) · Science · doi:10.1126/science.1106036 · Cited by 830 · see citing works

Beclin–phosphatidylinositol 3‐kinase complex functions at the trans‐Golgi network

Kihara, A., Kabeya, Y., Ohsumi, Y., & Yoshimori, T. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve061 · Cited by 813 · see citing works

Eating Oneself and Uninvited Guests

Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.01.005 · Cited by 785 · see citing works

Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

MacMicking, J. D., Taylor, G. A., & McKinney, J. D. (2003) · Science · doi:10.1126/science.1088063 · Cited by 685 · see citing works

Autophagy Controls Salmonella Infection in Response to Damage to the Salmonella-containing Vacuole

Birmingham, C. L., Smith, A. C., Bakowski, M. A., Yoshimori, T., & Brumell, J. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509157200 · Cited by 658 · see citing works

The mitochondrial permeability transition initiates autophagy in rat hepatocytes

Elmore, S. P., Qian, T., Grissom, S. F., & Lemasters, J. J. (2001) · The FASEB Journal · doi:10.1096/fj.01-0206fje · Cited by 607 · see citing works

The Evolutionarily Conserved Domain of Beclin 1 is Required for Vps34 Binding, Autophagy, and Tumor Suppressor Function

Furuya, N., Yu, J., Byfield, M. P., Pattingre, S., & Levine, B. (2005) · Autophagy · doi:10.4161/auto.1.1.1542 · Cited by 430 · see citing works

Disruption of Toxoplasma gondii Parasitophorous Vacuoles by the Mouse p47-Resistance GTPases

Martens, S., Parvanova, I., Zerrahn, J., Griffiths, G. W., Schell, G., Reichmann, G., & Howard, J. C. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010024 · Cited by 356 · see citing works

Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking

Zeng, X., Overmeyer, J. H., & Maltese, W. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.02735 · Cited by 331 · see citing works

The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage

Bekpen, C., Hunn, J. P., Rohde, C., Parvanova, I., Guethlein, L., Dunn, D. M., Glowalla, E., Leptin, M., & Howard, J. C. (2005) · Genome biology · doi:10.1186/gb-2005-6-11-r92 · Cited by 294 · see citing works

p47 GTPases: regulators of immunity to intracellular pathogens

Taylor, G. A., Feng, C. G., & Sher, A. (2004) · Nature reviews. Immunology · doi:10.1038/nri1270 · Cited by 252 · see citing works

Autophagy in Innate and Adaptive Immunity

Xu, Y., & Eissa, N. T. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200909-103js · Cited by 242 · see citing works

Non-selective autophagy.

Seglen, P. O., Gordon, P. B., & Holen, I. (1990) · PubMed · Cited by 124 · see citing works

Mice Deficient in LRG-47 Display Increased Susceptibility to Mycobacterial Infection Associated with the Induction of Lymphopenia

Feng, C. G., Collazo, C. M., Eckhaus, M., Hieny, S. E., Belkaid, Y., Elkins, K. L., Jankovic, D. L., Taylor, G. A., & Sher, A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.1163 · Cited by 121 · see citing works

Autophagy in innate and adaptive immunity.

Deretic, V. (2005) · Trends in immunology · doi:10.1016/j.it.2005.08.003 · Cited by 89 · see citing works

Immune control of phagosomal bacteria by p47 GTPases

MacMicking, J. D. (2005) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.12.012 · Cited by 80 · see citing works

Autophagy in Immunity and Infection

Deretic, V. P. (2006) · Wiley eBooks · doi:10.1002/352760880x · Cited by 10 · see citing works

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works

Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364 · see citing works

Autophagy in immunity and inflammation

Levine, B., Mizushima, N., & Virgin, H. W. (2011) · Nature · doi:10.1038/nature09782 · Cited by 3,289 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) ¹

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,622 · see citing works

Inflammatory bowel disease

Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806 · see citing works

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769 · see citing works

Autophagy in major human diseases

Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M. K., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108863 · Cited by 1,585 · see citing works

Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

Sanjuan, M. A., Dillon, C. P., Tait, S. W. G., Moshiach, S., Dorsey, F., Connell, S., Komatsu, M., Tanaka, K., Cleveland, J. L., Withoff, S., et al. (2007) · Nature · doi:10.1038/nature06421 · Cited by 1,347 · see citing works

Macrophage defense mechanisms against intracellular bacteria

Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989 · see citing works

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

Flannagan, R. S., Cosío, G., & Grinstein, S. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2128 · Cited by 947 · see citing works

The genetics and immunopathogenesis of inflammatory bowel disease

Cho, J. H. (2008) · Nature Reviews Immunology · doi:10.1038/nri2340 · Cited by 940 · see citing works

Autophagy-Independent Functions of the Autophagy Machinery

Galluzzi, L., & Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.05.026 · Cited by 863 · see citing works

Autophagy in inflammation, infection, and immunometabolism

Deretic, V. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.018 · Cited by 862 · see citing works

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

Watson, R. O., Manzanillo, P. S., & Cox, J. S. (2012) · Cell · doi:10.1016/j.cell.2012.06.040 · Cited by 755 · see citing works

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

McCarroll, S. A., Huett, A., Kuballa, P., Chilewski, S. D., Landry, A., Goyette, P., Zody, M. C., Hall, J. L., Brant, S. R., Cho, J. H., et al. (2008) · Nature Genetics · doi:10.1038/ng.215 · Cited by 655 · see citing works

Common disorders are quantitative traits

Plomin, R., Haworth, C. M. A., & Davis, O. S. P. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2670 · Cited by 670 · see citing works

Autophagy and inflammation in chronic respiratory disease

Racanelli, A. C., Kikkers, S. A., Choi, A. M. K., & Cloonan, S. M. (2018) · Autophagy · doi:10.1080/15548627.2017.1389823 · Cited by 547 · see citing works

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

Kyei, G. B., Dinkins, C., Davis, A. S., Roberts, E., Singh, S. B., Dong, C., Wu, L., Kominami, E., Ueno, T., Yamamoto, A., et al. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903070 · Cited by 509 · see citing works

A Family of IFN-γ–Inducible 65-kD GTPases Protects Against Bacterial Infection

Kim, B.-H., Shenoy, A. R., Kumar, P., Das, R., Tiwari, S., & MacMicking, J. D. (2011) · Science · doi:10.1126/science.1201711 · Cited by 494 · see citing works

Autophagy in Antimicrobial Immunity

Gomes, L. C., & Dikic, I. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.009 · Cited by 350 · see citing works

Modulation of inflammation by autophagy: Consequences for human disease

Netea-Maier, R. T., Plantinga, T. S., van de Veerdonk, F. L., Smit, J. W., & Netea, M. G. (2016) · Autophagy · doi:10.1080/15548627.2015.1071759 · Cited by 349 · see citing works

Survival of Mycobacteria in Macrophages Is Mediated by Coronin 1-Dependent Activation of Calcineurin

Jayachandran, R., Sundaramurthy, V., Combaluzier, B., Mueller, P., Korf, H., Huygen, K., Miyazaki, T., Albrecht, I., Massner, J., & Pieters, J. (2007) · Cell · doi:10.1016/j.cell.2007.04.043 · Cited by 310 · see citing works

TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia

Lee, J.-W., Nam, H., Kim, L. E., Jeon, Y., Min, H., Ha, S., Lee, Y., Kim, S.-Y., Lee, S. J., Kim, E.-K., et al. (2019) · Autophagy · doi:10.1080/15548627.2018.1556946 · Cited by 260 · see citing works

<i>Listeria monocytogenes</i>Evades Killing by Autophagy During Colonization of Host Cells

Birmingham, C. L., Canadien, V., Gouin, E., Troy, E. B., Yoshimori, T., Cossart, P., Higgins, D. E., & Brumell, J. H. (2007) · Autophagy · doi:10.4161/auto.4450 · Cited by 254 · see citing works

The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy

Mehto, S., Jena, K. K., Nath, P., Chauhan, S., Kolapalli, S. P., Das, S. K., Sahoo, P. K., Jain, A., Taylor, G. A., & Chauhan, S. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.11.018 · Cited by 238 · see citing works

Chronic granulomatous disease

Roos, D. (2016) · British Medical Bulletin · doi:10.1093/bmb/ldw009 · Cited by 212 · see citing works

Sirt3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions

Kim, T. S., Jin, Y. B., Kim, Y. S., Kim, S., Kim, J. K., Lee, H.-M., Suh, H.-W., Choe, J. H., Kim, Y. J., Koo, B.-S., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1582743 · Cited by 172 · see citing works

Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide

Axelrod, S., Oschkinat, H., Enders, J., Schlegel, B., Brinkmann, V., Kaufmann, S. H. E., Haas, A., & Schaible, U. E. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01147.x · Cited by 141 · see citing works

Feast or famine: the host-pathogen battle over amino acids

Zhang, Y. J., & Rubin, E. J. (2013) · Cellular Microbiology · doi:10.1111/cmi.12140 · Cited by 117 · see citing works

Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens

Kumar, S., Jain, A., Choi, S. W., da Silva, G. P. D., Allers, L., Mudd, M. H., Peters, R. S., Anonsen, J. H., Rusten, T.-E., Lazarou, M., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0549-1 · Cited by 95 · see citing works

Innate immunity to mycobacteria: vitamin D and autophagy

Jo, E.-K. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01491.x · Cited by 98 · see citing works

Autophagy in Pulmonary Diseases

Nakahira, K., Pabon Porras, M. A., & Choi, A. M. K. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201512-2468so · Cited by 78 · see citing works

Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1

Oikonomou, V., Moretti, S., Renga, G., Galosi, C., Borghi, M., Pariano, M., Puccetti, M., Palmerini, C. A., Amico, L., Carotti, A., et al. (2016) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2016.10.012 · Cited by 68 · see citing works

Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases

Panda, P. K., Fahrner, A., Vats, S., Seranova, E., Sharma, V., Chipara, M., Desai, P., Torresi, J., Rosenstock, T., Kumar, D., et al. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00038 · Cited by 50 · see citing works

Seasonal variation in onset and relapse of IBD and a model to predict the frequency of onset, relapse, and severity of IBD based on artificial neural network

Peng, J. C., Ran, Z. H., & Shen, J. (2015) · International Journal of Colorectal Disease · doi:10.1007/s00384-015-2250-6 · Cited by 40 · see citing works

Linking Lysosomal Trafficking Defects with Changes in Aging and Stress Response in<i>Drosophila</i>

Simonsen, A., Cumming, R. C., & Finley, K. D. (2007) · Autophagy · doi:10.4161/auto.4604 · Cited by 37 · see citing works

E. coli-mediated gut inflammation in genetically predisposed Crohn's disease patients

Barnich, N., Denizot, J., & Darfeuille-Michaud, A. (2013) · Pathologie Biologie · doi:10.1016/j.patbio.2010.01.004 · Cited by 34 · see citing works

Single Nucleotide Polymorphisms in the Bovine TLR2 Extracellular Domain Contribute to Breed and Species-Specific Innate Immune Functionality

Bartens, M.-C., Gibson, A. J., Etherington, G. J., Di Palma, F., Holder, A., Werling, D., & Willcocks, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.764390 · Cited by 19 · see citing works

Macrophage-Listeria interactions.

Campbell, P. A. (1994) · PubMed · Cited by 36 · see citing works

Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages.

Marra, A., Blander, S. J., Horwitz, M. A., et al. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9607 · Cited by 315 · see citing works

Survival of Mycobacterium avium and Mycobacterium tuberculosis in Acidified Vacuoles of Murine Macrophages

Gomes, M. S., Paul, S., Moreira, A. L., Appelberg, R., Rabinovitch, M., & Kaplan, G. (1999) · Infection and Immunity · doi:10.1128/iai.67.7.3199-3206.1999 · Cited by 136 · see citing works

Mycobacterium microti may protect itself from intracellular destruction by releasing cyclic AMP into phagosomes

Lowrie, D. B., Jackett, P. S., & Ratcliffe, N. A. (1975) · Nature · doi:10.1038/254600a0 · Cited by 107 · see citing works

The role of the small GTPase Rab20 in Mycobacterium tuberculosis phagosome biology

Schnettger, L. (2016) · UCL Discovery (University College London) · Cited by 1 · see citing works