The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Synthetic Biology Moving into the Clinic
Abstract
Synthetic biology is an emerging field focused on engineering biomolecular systems and cellular capabilities for a variety of applications. Substantial progress began a little over a decade ago with the creation of synthetic gene networks inspired by electrical engineering. Since then, the field has designed and built increasingly complex circuits and constructs and begun to use these systems in a variety of settings, including the clinic. These efforts include the development of synthetic biology therapies for the treatment of infectious diseases and cancer, as well as approaches in vaccine development, microbiome engineering, cell therapy, and regenerative medicine. Here, we highlight advances in the biomedical application of synthetic biology and discuss the field’s clinical potential.
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Warren, L., Manos, P. D., Ahfeldt, T., Loh, Y.-H., Li, H., Lau, F., Ebina, W., Mandal, P. K., Smith, Z. D., Meissner, A., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.012 · Cited by 2,662
Self-citationVirus attenuation by genome-scale changes in codon pair bias
Coleman, J. R., Papamichail, D., Skiena, S., Futcher, B., Wimmer, E., & Mueller, S. (2008) · Science · doi:10.1126/science.1155761 · Cited by 715
Secretion of insulinotropic proteins by commensal bacteria: rewiring the gut to treat diabetes
Duan, F., Curtis, K. L., & March, J. C. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01019-08 · Cited by 86
Cited by
Garrett, W. S. (2015) · Science · doi:10.1126/science.aaa4972 · Cited by 1,404
Genetic circuit design automation
Nielsen, A. A. K., Der, B. S., Shin, J., Vaidyanathan, P., Paralanov, V., Strychalski, E. A., Ross, D., Densmore, D., & Voigt, C. A. (2016) · Science · doi:10.1126/science.aac7341 · Cited by 1,020
A brief history of synthetic biology
Cameron, D. E., Bashor, C. J., & Collins, J. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3239 · Cited by 933
Self-citationPrinciples of genetic circuit design
Brophy, J. A. N., & Voigt, C. A. (2014) · Nature Methods · doi:10.1038/nmeth.2926 · Cited by 931
Synchronized cycles of bacterial lysis for in vivo delivery
Din, M. O., Danino, T., Prindle, A., Skalak, M., Selimkhanov, J., Allen, K., Julio, E., Atolia, E., Tsimring, L. S., Bhatia, S. N., et al. (2016) · Nature · doi:10.1038/nature18930 · Cited by 784
Metadata
- Authors
- Ruder, W. C., Lu, T., & Collins, J. J.
- Venue
- Science
- Published
- 2011-09-02
- Volume
- 333
- Issue
- 6047
- Pages
- 1248-1252
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2160237938
- Cited by
- 412
- References
- 3
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ruder, W. C., Lu, T., & Collins, J. J. (2011). Synthetic Biology Moving into the Clinic. Science. https://doi.org/10.1126/science.1206843
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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