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Locally Synchronized Synaptic Inputs
Open accessAbstract
Synaptic inputs on dendrites are nonlinearly converted to action potential outputs, yet the spatiotemporal patterns of dendritic activation remain to be elucidated at single-synapse resolution. In rodents, we optically imaged synaptic activities from hundreds of dendritic spines in hippocampal and neocortical pyramidal neurons ex vivo and in vivo. Adjacent spines were frequently synchronized in spontaneously active networks, thereby forming dendritic foci that received locally convergent inputs from presynaptic cell assemblies. This precise subcellular geometry manifested itself during N-methyl-D-aspartate receptor-dependent circuit remodeling. Thus, clustered synaptic plasticity is innately programmed to compartmentalize correlated inputs along dendrites and may reify nonlinear synaptic integration.
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Metadata
- Authors
- Takahashi, N., Kitamura, K., Matsuo, N., Mayford, M., Kano, M., Matsuki, N., & Ikegaya, Y.
- Affiliations
- The University of Tokyo (JP)
- Japan Science and Technology Agency (JP)
- Kyoto University (JP)
- Scripps Research Institute (US)
- Corresponding author
- Ikegaya, Yuji
- Venue
- Science
- Published
- 2012-01-20
- Volume
- 335
- Issue
- 6066
- Pages
- 353-356
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2019251983
- Cited by
- 352
- References
- 37
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 37 · 2023: 21 · 2022: 16 · 2021: 26 · 2020: 17 · 2019: 17 · 2018: 22 · 2017: 20 · 2016: 25 · 2015: 26 · 2014: 31 · 2013: 27 · 2012: 27
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- green
- pure.teikyo.jp
- Licence
- cc-by-nc-nd
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Funders
- Japan Society for the Promotion of Science (22390012, 21220006, 23115504, 22680031, 22650083, 21680027, 23650204)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dendritic spines, dendritic integration, pyramidal neurons, hippocampus, neocortex, spontaneous network activity
- MeSH terms
- Action Potentials, Animals, Calcium, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neuronal Plasticity, Organ Culture Techniques, Somatosensory Cortex, Synapses, Receptors, N-Methyl-D-Aspartate, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Dendritic Spines, Mice, Rats, CA3 Region, Hippocampal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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