Synfire Chains and Cortical Songs: Temporal Modules of Cortical Activity
Abstract
How can neural activity propagate through cortical networks built with weak, stochastic synapses? We find precise repetitions of spontaneous patterns of synaptic inputs in neocortical neurons in vivo and in vitro. These patterns repeat after minutes, maintaining millisecond accuracy. Calcium imaging of slices reveals reactivation of sequences of cells during the occurrence of repeated intracellular synaptic patterns. The spontaneous activity drifts with time, engaging different cells. Sequences of active neurons have distinct spatial structures and are repeated in the same order over tens of seconds, revealing modular temporal dynamics. Higher order sequences are replayed with compressed timing.
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Repeated spontaneous activation of neuron assemblies does occur.
“Repeated spontaneous activation of neuron assemblies does occur106,107”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [106]
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Neural networks and physical systems with emergent collective computational abilities.
Hopfield, J. J. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.8.2554 · Cited by 19,270 · see citing works
Maass, W., Natschläger, T., & Markram, H. (2002) · Neural Computation · doi:10.1162/089976602760407955 · Cited by 4,025 · see citing works
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663 · see citing works
Llinás, R. R. (1988) · Science · doi:10.1126/science.3059497 · Cited by 2,285 · see citing works
Synaptic depression and cortical gain control
Abbott, L. F., Varela, J. A., Sen, K., & Nelson, S. B. (1997) · Science · doi:10.1126/science.275.5297.221 · Cited by 1,690 · see citing works
Abeles, M. (1991) · Cambridge University Press eBooks · doi:10.1017/cbo9780511574566 · Cited by 1,380 · see citing works
Replay of neuronal firing sequences in rat hippocampus during sleep following spatial experience
Skaggs, W. E., & McNaughton, B. L. (1996) · Science · doi:10.1126/science.271.5257.1870 · Cited by 1,173 · see citing works
Temporally structured replay of awake hippocampal ensemble activity during rapid eye movement sleep
Louie, K., & Wilson, M. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00186-6 · Cited by 1,148 · see citing works
Synaptic reverberation underlying mnemonic persistent activity
Wang, X.-J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01868-3 · Cited by 1,059 · see citing works
Turning on and off recurrent balanced cortical activity
Shu, Y., Hasenstaub, A., & McCormick, D. A. (2003) · Nature · doi:10.1038/nature01616 · Cited by 1,054 · see citing works
Stable propagation of synchronous spiking in cortical neural networks
Diesmann, M., Gewaltig, M.-O., & Aertsen, A. (1999) · Nature · doi:10.1038/990101 · Cited by 1,003 · see citing works
An ultra-sparse code underliesthe generation of neural sequences in a songbird
Hahnloser, R. H. R., Kozhevnikov, A. A., & Fee, M. S. (2002) · Nature · doi:10.1038/nature00974 · Cited by 986 · see citing works
Replay and Time Compression of Recurring Spike Sequences in the Hippocampus
Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J., & Buzsáki, G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09497.1999 · Cited by 932 · see citing works
Redistribution of synaptic efficacy between neocortical pyramidal neurons
Markram, H., & Tsodyks, M. V. (1996) · Nature · doi:10.1038/382807a0 · Cited by 856 · see citing works
Attractor dynamics of network UP states in the neocortex
Cossart, R., Aronov, D., & Yuste, R. (2003) · Nature · doi:10.1038/nature01614 · Cited by 659 · see citing works
Self-citationSpatiotemporal firing patterns in the frontal cortex of behaving monkeys
Abeles, M., Bergman, H., Margalit, E., & Vaadia, E. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.4.1629 · Cited by 600 · see citing works
Yuste, R., & Katz, L. C. (1991) · Neuron · doi:10.1016/0896-6273(91)90243-s · Cited by 591 · see citing works
Self-citationPerceptual Neuroscience: The Cerebral Cortex
Mountcastle, V. B. (1998) · Cited by 481 · see citing works
I of the Vortex: From Neurons to Self
Llinás, R. R. (2000) · Cited by 470 · see citing works
I of the Vortex: From Neurons to Self
Llinás, R. R. (2001) · doi:10.7551/mitpress/3626.001.0001 · Cited by 469 · see citing works
Synchronous Membrane Potential Fluctuations in Neurons of the Cat Visual Cortex
Lampl, I., Reichova, I., & Ferster, D. (1999) · Neuron · doi:10.1016/s0896-6273(00)81096-x · Cited by 434 · see citing works
Self-citationANALYSIS OF THE ACTIVITY OF THE CHAINS OF INTERNUNCIAL NEURONS
de N�, R. L. (1938) · Journal of Neurophysiology · doi:10.1152/jn.1938.1.3.207 · Cited by 394 · see citing works
Dynamics of Spontaneous Activity in Neocortical Slices
Mao, B.-Q., Hamzei‐Sichani, F., Aronov, D., Froemke, R. C., & Yuste, R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00518-9 · Cited by 319 · see citing works
Self-citationStochastic Nature of Precisely Timed Spike Patterns in Visual System Neuronal Responses
Oram, M. W., Wiener, M. C., Lestienne, R., & Richmond, B. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.6.3021 · Cited by 251 · see citing works
Bienenstock, E. (1995) · Network Computation in Neural Systems · doi:10.1088/0954-898x_6_2_004 · Cited by 208 · see citing works
Stereotyped Position of Local Synaptic Targets in Neocortex
Kozloski, J., Hamzei‐Sichani, F., & Yuste, R. (2001) · Science · doi:10.1126/science.293.5531.868 · Cited by 179 · see citing works
Self-citationThe Synaptic Hypothesis of Schizophrenia
Frankle, W. G., Lerma, J., & Laruelle, M. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00423-9 · Cited by 167 · see citing works
Song learning in birds: the relation between perception and production
Nottebohm, F., Alvarez-Buylla, A., Cynx, J., Kirn, J., Ling, C.-Y., Nottebohm, M., Suter, R., Tolles, A., & Williams, H. (1990) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1990.0156 · Cited by 145 · see citing works
Song learning in birds: the relation between perception and production
Nottebohm, F., Álvarez-Buylla, A., Cynx, J., Kirn, J. R., Ling, C., Nottebohm, M. E., Suter, R. B., Tolles, A., & Williams, H. (1991) · doi:10.1093/acprof:oso/9780198521983.003.0003 · Cited by 126 · see citing works
Silberberg, G., Wu, C.-Z., & Markram, H. (2004) · Journal of Physiology · doi:10.1113/jphysiol.2004.060962 · Cited by 83 · see citing works
Timing of neural responses in cortical organotypic slices
Buonomano, D. V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0736909100 · Cited by 83 · see citing works
Neuronal assemblies: Single cortical neurons are obedient members of a huge orchestra
Grinvald, A., Arieli, A., Tsodyks, M. V., & Kenet, T. (2003) · Biopolymers · doi:10.1002/bip.10273 · Cited by 61 · see citing works
Neuronal Communication: Cooperativity of unreliable neurons
Stevens, C. F. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00062-2 · Cited by 25 · see citing works
Flagged first, then by citations
1 of the 34 references couldn’t be matched to a known paper.
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Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,831 · see citing works
Weak pairwise correlations imply strongly correlated network states in a neural population
Schneidman, E., Berry, M. J., Segev, R., & Bialek, W. (2006) · Nature · doi:10.1038/nature04701 · Cited by 1,701 · see citing works
Highly nonrandom features of synaptic connectivity in local cortical circuits
Song, S., Sjöström, P. J., Reigl, M., Nelson, S., & Chklovskii, D. B. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030068 · Cited by 1,512 · see citing works
Neural syntax: cell assemblies, synapsembles, and readers
Buzsáki, G. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.023 · Cited by 1,289 · see citing works
Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain
Dodt, H., Leischner, U., Schierloh, A., Jährling, N., Mauch, C. P., Deininger, K., Deussing, J. M., Eder, M., Zieglgänsberger, W., & Becker, K. (2007) · Nature Methods · doi:10.1038/nmeth1036 · Cited by 1,240 · see citing works
Polychronization: Computation with Spikes
Izhikevich, E. M. (2005) · Neural Computation · doi:10.1162/089976606775093882 · Cited by 1,066 · see citing works
Dynamical principles in neuroscience
Rabinovich, M. I., Varona, P., Selverston, A. I., & Abarbanel, H. D. I. (2006) · Reviews of Modern Physics · doi:10.1103/revmodphys.78.1213 · Cited by 819 · see citing works
Electrical activity in early neuronal development
Spitzer, N. C. (2006) · Nature · doi:10.1038/nature05300 · Cited by 779 · see citing works
From the neuron doctrine to neural networks
Yuste, R. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3962 · Cited by 748 · see citing works
Self-citationStatistically optimal perception and learning: from behavior to neural representations
Fiser, J., Berkes, P., Orbán, G., & Lengyel, M. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.01.003 · Cited by 672 · see citing works
MacDonald, S. W. S., Nyberg, L., & Bäckman, L. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.06.011 · Cited by 664 · see citing works
Thalamic amplification of cortical connectivity sustains attentional control
Schmitt, L. I., Wimmer, R. D., Nakajima, M., Happ, M., Mofakham, S., & Halassa, M. M. (2017) · Nature · doi:10.1038/nature22073 · Cited by 663 · see citing works
Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits
Szabadics, J., Varga, C., Molnár, G., Oláh, S., Barzó, P., & Tamás, G. (2006) · Science · doi:10.1126/science.1121325 · Cited by 598 · see citing works
Spontaneous Events Outline the Realm of Possible Sensory Responses in Neocortical Populations
Luczak, A., Barthó, P., & Harris, K. D. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.014 · Cited by 593 · see citing works
González‐Burgos, G., & Lewis, D. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn070 · Cited by 568 · see citing works
Sequential structure of neocortical spontaneous activity <i>in vivo</i>
Luczak, A., Barthó, P., Marguet, S. L., Buzsáki, G., & Harris, K. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605643104 · Cited by 515 · see citing works
Imaging input and output of neocortical networks <i>in vivo</i>
Kerr, J. N. D., Greenberg, D., & Helmchen, F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506029102 · Cited by 474 · see citing works
Haldeman, C. L., & Beggs, J. M. (2005) · Physical Review Letters · doi:10.1103/physrevlett.94.058101 · Cited by 453 · see citing works
Fast nonnegative deconvolution for spike train inference from population calcium imaging
Vogelstein, J. T., Packer, A. M., Machado, T. A., Sippy, T., Babadi, B., Yuste, R., & Paninski, L. (2010) · Journal of Neurophysiology · doi:10.1152/jn.01073.2009 · Cited by 449 · see citing works
Self-citationKumar, A., Rotter, S., & Aertsen, A. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2886 · Cited by 448 · see citing works
The restless brain: How intrinsic activity organizes brain function
Raichle, M. E. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0172 · Cited by 433 · see citing works
Evidence of an inhibitory restraint of seizure activity in humans
Schevon, C. A., Weiss, S. A., McKhann, G. M., Goodman, R. R., Yuste, R., Emerson, R. G., & Trevelyan, A. J. (2012) · Nature Communications · doi:10.1038/ncomms2056 · Cited by 428 · see citing works
Self-citationDynamics and Effective Topology Underlying Synchronization in Networks of Cortical Neurons
Eytan, D., & Marom, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1627-06.2006 · Cited by 402 · see citing works
Support for a synaptic chain model of neuronal sequence generation
Long, M. A., Jin, D. Z., & Fee, M. S. (2010) · Nature · doi:10.1038/nature09514 · Cited by 396 · see citing works
The organizing principles of neuronal avalanches: cell assemblies in the cortex?
Plenz, D., & Thiagarajan, T. C. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.01.005 · Cited by 373 · see citing works
Internal Dynamics Determine the Cortical Response to Thalamic Stimulation
MacLean, J. N., Watson, B. O., Aaron, G. B., & Yuste, R. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.035 · Cited by 373 · see citing works
Self-citationBuzsáki, G. (2019) · doi:10.1093/oso/9780190905385.001.0001 · Cited by 358 · see citing works
Regulation of spike timing in visual cortical circuits
Tiesinga, P. H. E., Fellous, J., & B, T. J. S. A. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2315 · Cited by 352 · see citing works
Nanotools for Neuroscience and Brain Activity Mapping
Alivisatos, A. P., Andrews, A. M., Boyden, E. S., Chun, M., Church, G. M., Deisseroth, K. A., Donoghue, J. P., Fraser, S. E., Lippincott‐Schwartz, J., Looger, L. L., et al. (2013) · ACS Nano · doi:10.1021/nn4012847 · Cited by 353 · see citing works
Self-citationThe cortex as a central pattern generator
Yuste, R., MacLean, J. N., Smith, J., & Lansner, A. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1686 · Cited by 355 · see citing works
Self-citationLocally synchronized synaptic inputs
Takahashi, N., Kitamura, K., Matsuo, N., Mayford, M., Kano, M., Matsuki, N., & Ikegaya, Y. (2012) · Science · doi:10.1126/science.1210362 · Cited by 352 · see citing works
Self-citationRecurrent network models of sequence generation and memory
Rajan, K., Harvey, C. D., & Tank, D. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.009 · Cited by 351 · see citing works
A Leaky Integrate-and-Fire Laser Neuron for Ultrafast Cognitive Computing
Nahmias, M. A., Shastri, B. J., Tait, A. N., & Prucnal, P. R. (2013) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2013.2257700 · Cited by 346 · see citing works
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Trevelyan, A. J., Sussillo, D., Watson, B. O., & Yuste, R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2787-06.2006 · Cited by 344 · see citing works
Self-citationCompetitive STDP-Based Spike Pattern Learning
Masquelier, T., Guyonneau, R., & Thorpe, S. J. (2009) · Neural Computation · doi:10.1162/neco.2008.06-08-804 · Cited by 343 · see citing works
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Carrillo‐Reid, L., Han, S., Yang, W., Akrouh, A., & Yuste, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.045 · Cited by 316 · see citing works
Self-citationThe right time to learn: Mechanisms and optimization of spaced learning
Smolen, P., Zhang, Y., & Byrne, J. H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.18 · Cited by 326 · see citing works
Universal features of correlated bursty behaviour
Karsai, M., Kaski, K. K., Barabási, A.-Ĺ., & Kertész, J. (2012) · Scientific Reports · doi:10.1038/srep00397 · Cited by 313 · see citing works
A Maximum Entropy Model Applied to Spatial and Temporal Correlations from Cortical NetworksIn Vitro
Tang, A., Jackson, D., Hobbs, J., Chen, W., Smith, J. L., Patel, H., Prieto, A., Petrusca, D., Grivich, M. I., Sher, A., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3359-07.2008 · Cited by 304 · see citing works
Temporally precise single-cell-resolution optogenetics
Shemesh, O. A., Tanese, D., Zampini, V., Linghu, C., Piatkevich, K. D., Ronzitti, E., Papagiakoumou, E. I., Boyden, E. S., & Emiliani, V. (2017) · Nature Neuroscience · doi:10.1038/s41593-017-0018-8 · Cited by 270 · see citing works
Visual stimuli recruit intrinsically generated cortical ensembles
Miller, J.-E. K., Ayzenshtat, I., Carrillo-Reid, L., & Yuste, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406077111 · Cited by 288 · see citing works
Self-citationThe Slow Oscillation in Cortical and Thalamic Networks: Mechanisms and Functions
Neske, G. T. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00088 · Cited by 283 · see citing works
A nanoelectrode array for obtaining intracellular recordings from thousands of connected neurons
Abbott, J., Ye, T., Krenek, K., Gertner, R. S., Ban, S., Kim, Y., Qin, L., Wu, W., Park, H., & Ham, D. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0455-7 · Cited by 272 · see citing works
Philosophy of the Spike: Rate-Based vs. Spike-Based Theories of the Brain
Brette, R. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00151 · Cited by 264 · see citing works
Interaction between neocortical and hippocampal networks via slow oscillations
Sirota, A., & Buzsáki, G. (2005) · Thalamus and Related Systems · doi:10.1017/s1472928807000258 · Cited by 270 · see citing works
Fiete, I., Senn, W., Wang, C. Z.-H., & Hahnloser, R. H. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.003 · Cited by 269 · see citing works
Feedforward Inhibition Contributes to the Control of Epileptiform Propagation Speed
Trevelyan, A. J., Sussillo, D., & Yuste, R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0145-07.2007 · Cited by 262 · see citing works
Self-citationNeurogeometry and potential synaptic connectivity
STEPANYANTS, A., & CHKLOVSKII, D. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.05.006 · Cited by 254 · see citing works
Spatial Organization of Neuronal Population Responses in Layer 2/3 of Rat Barrel Cortex
Kerr, J. N. D., de Kock, C. P. J., Greenberg, D. S., Bruno, R. M., Sakmann, B. J., & Helmchen, F. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2210-07.2007 · Cited by 252 · see citing works
Inoue, M., Takeuchi, A., Manita, S., Horigane, S., Sakamoto, M., Kawakami, R., Yamaguchi, K., Otomo, K., Yokoyama, H., Kim, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.007 · Cited by 238 · see citing works
Relating neuronal firing patterns to functional differentiation of cerebral cortex.
Shinomoto, S., Kim, H., Shimokawa, T., Matsuno, N., Funahashi, S., Shima, K., Fujita, I., Tamura, H., Doi, T., Kawano, K., et al. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000433 · Cited by 239 · see citing works
Targeted bulk-loading of fluorescent indicators for two-photon brain imaging in vivo
Garaschuk, O., Milos, R., & Konnerth, A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.58 · Cited by 235 · see citing works
Spontaneous and driven cortical activity: implications for computation.
Ringach, D. L. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.07.005 · Cited by 234 · see citing works
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Yassin, L., Benedetti, B. L., Jouhanneau, J.-S., Wen, J. A., Poulet, J. F. A., & Barth, A. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.029 · Cited by 227 · see citing works
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Spike Inference from Calcium Imaging Using Sequential Monte Carlo Methods
Vogelstein, J. T., Watson, B. O., Packer, A. M., Yuste, R., Jedynak, B., & Paninski, L. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.08.005 · Cited by 223 · see citing works
Self-citationPredicting spike timing of neocortical pyramidal neurons by simple threshold models
Jolivet, R., Rauch, A., Lüscher, H., & Wulfram Gerstner, B. (2006) · Journal of Computational Neuroscience · doi:10.1007/s10827-006-7074-5 · Cited by 211 · see citing works
Topological analysis of population activity in visual cortex
Singh, G., Memoli, F., Ishkhanov, T., Sapiro, G., Carlsson, G., & Ringach, D. L. (2008) · Journal of Vision · doi:10.1167/8.8.11 · Cited by 213 · see citing works
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Sato, T., Gray, N. W., Mainen, Z. F., & Svoboda, K. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050189 · Cited by 211 · see citing works
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Knöpfel, T. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3293 · Cited by 205 · see citing works
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Reiff, D. F., Ihring, A., Guerrero, G., Isacoff, E. Y., Joesch, M., Nakai, J., & Borst, A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4900-04.2005 · Cited by 205 · see citing works
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Ribeiro, T. L., Copelli, M., Caixeta, F. V., Belchior, H., Chialvo, D. R., Nicolelis, M. A. L., & Ribeiro, S. T. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014129 · Cited by 196 · see citing works
Egawa, T., Hanaoka, K., Koide, Y., Ujita, S., Takahashi, N., Ikegaya, Y., Matsuki, N., Terai, T., Ueno, T., Komatsu, T., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja205809h · Cited by 200 · see citing works
Self-citationPacket-based communication in the cortex
Luczak, A., McNaughton, B. L., & Harris, K. D. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4026 · Cited by 192 · see citing works
Complex Events Initiated by Individual Spikes in the Human Cerebral Cortex
Molnár, G., Oláh, S., Komlósi, G., Füle, M., Szabadics, J., Varga, C., Barzó, P., & Tamás, G. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060222 · Cited by 197 · see citing works
Neural blackboard architectures of combinatorial structures in cognition
van der Velde, F., & de Kamps, M. (2006) · Behavioral and Brain Sciences · doi:10.1017/s0140525x06009022 · Cited by 195 · see citing works
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Galán, R. F. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002148 · Cited by 191 · see citing works
Encoding Network States by Striatal Cell Assemblies
Carrillo‐Reid, L., Tecuapetla, F., Tapia, D., Hernández‐Cruz, A., Galarraga, E., Drucker-Colı́n, R., & Bargas, J. (2008) · Journal of Neurophysiology · doi:10.1152/jn.01131.2007 · Cited by 187 · see citing works
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Mitra, A., Snyder, A. Z., Blazey, T., & Raichle, M. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503960112 · Cited by 186 · see citing works
Post-translational protein modification as the substrate for long-lasting memory
Routtenberg, A., & Rekart, J. L. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.11.006 · Cited by 188 · see citing works
What can we learn from synaptic weight distributions?
Barbour, B., Brunel, N., Hakim, V., & Nadal, J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.09.005 · Cited by 178 · see citing works
Natural world physical, brain operational, and mind phenomenal space–time
Fingelkurts, A. A., Fingelkurts, A. A., & Neves, C. F. H. (2010) · Physics of Life Reviews · doi:10.1016/j.plrev.2010.04.001 · Cited by 182 · see citing works
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Sasaki, T., Matsuki, N., & Ikegaya, Y. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4514-06.2007 · Cited by 180 · see citing works
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Nigam, S., Shimono, M., Ito, S., Yeh, F.-C., Timme, N. M., Myroshnychenko, M., Lapish, C. C., Tosi, Z., Hottowy, P., Smith, W. C., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2177-15.2016 · Cited by 180 · see citing works
The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System
Totah, N. K., Neves, R. M., Panzeri, S., Logothetis, N. K., & Eschenko, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.037 · Cited by 179 · see citing works
Made-to-order spiking neuron model equipped with a multi-timescale adaptive threshold
Kobayashi, R. (2009) · Frontiers in Computational Neuroscience · doi:10.3389/neuro.10.009.2009 · Cited by 177 · see citing works
Synchronization likelihood with explicit time-frequency priors
Montez, T., Linkenkaer‐Hansen, K., van Dijk, B. W., & Stam, C. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.06.066 · Cited by 176 · see citing works
A hybrid approach to measuring electrical activity in genetically specified neurons
Chanda, B., Blunck, R., Faria, L. C., Schweizer, F. E., Módy, I., & Bezanilla, F. (2005) · Nature Neuroscience · doi:10.1038/nn1558 · Cited by 175 · see citing works
Portraits of communication in neuronal networks
Hahn, G., Ponce-Alvarez, A., Deco, G., Aertsen, A., & Kumar, A. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0094-0 · Cited by 171 · see citing works
Galimberti, I., Gogolla, N., Alberi, S., Santos, A. F., Müller, D., & Caroni, P. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.026 · Cited by 163 · see citing works
Ratté, S., Hong, S., Schutter, E. D., & Prescott, S. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.030 · Cited by 154 · see citing works
Dynamic functional connectivity
Ioannides, A. A. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.03.008 · Cited by 152 · see citing works
Non-Gaussian Membrane Potential Dynamics Imply Sparse, Synchronous Activity in Auditory Cortex
DeWeese, M. R., & Zador, A. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2813-06.2006 · Cited by 155 · see citing works
Barrel cortex and whisker-mediated behaviors
Brecht, M. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.07.008 · Cited by 149 · see citing works
Interpyramid Spike Transmission Stabilizes the Sparseness of Recurrent Network Activity
Ikegaya, Y., Sasaki, T., Ishikawa, D., Honma, N., Tao, K., Takahashi, N., Minamisawa, G., Ujita, S., & Matsuki, N. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs006 · Cited by 144 · see citing works
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Watanabe, T., Rees, G., & Masuda, N. (2019) · eLife · doi:10.7554/elife.42256 · Cited by 150 · see citing works
Bellay, T., Klaus, A., Seshadri, S., & Plenz, D. (2015) · eLife · doi:10.7554/elife.07224 · Cited by 144 · see citing works
The Structure of Large-Scale Synchronized Firing in Primate Retina
Shlens, J., Field, G. D., Gauthier, J. L., Greschner, M., Sher, A., Litke, A. M., & Chichilnisky, E. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5187-08.2009 · Cited by 148 · see citing works
Stewart, C. V., & Plenz, D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0723-06.2006 · Cited by 145 · see citing works
Fast Functional Imaging of Single Neurons Using Random-Access Multiphoton (RAMP) Microscopy
Iyer, V., Hoogland, T. M., & Saggau, P. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00865.2005 · Cited by 146 · see citing works
Schröter, M. S., Charlesworth, P., Kitzbichler, M. G., Paulsen, O., & Bullmore, E. T. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4259-14.2015 · Cited by 147 · see citing works
Persistently active, pacemaker-like neurons in neocortex
Bon-Jégo, M. L. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.009.2007 · Cited by 146 · see citing works
Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures
Rolston, J. D., Wagenaar, D. A., & Potter, S. M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.025 · Cited by 145 · see citing works
Synaptic mechanisms of persistent reverberatory activity in neuronal networks
Lau, P.-M., & Bi, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500717102 · Cited by 144 · see citing works
A benchmark test for a quantitative assessment of simple neuron models
Jolivet, R., Kobayashi, R., Rauch, A., Naud, R., Shinomoto, S., & Gerstner, W. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.11.006 · Cited by 144 · see citing works
Circuit topology for synchronizing neurons in spontaneously active networks
Takahashi, N., Sasaki, T., Matsumoto, W., Matsuki, N., & Ikegaya, Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914594107 · Cited by 143 · see citing works
Self-citationTwo-photon calcium imaging of neuronal activity
Grienberger, C., Giovannucci, A., Zeiger, W., & Portera‐Cailliau, C. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00147-1 · Cited by 148 · see citing works
Data-Driven Significance Estimation for Precise Spike Correlation
Grün, S. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00093.2008 · Cited by 142 · see citing works
Endogenous Sequential Cortical Activity Evoked by Visual Stimuli
Carrillo‐Reid, L., Miller, J.-E. K., Hamm, J. P., Jackson, J., & Yuste, R. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5214-14.2015 · Cited by 134 · see citing works
Self-citationReliable and Elastic Propagation of Cortical Seizures In Vivo
Wenzel, M., Hamm, J. P., Peterka, D. S., & Yuste, R. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.090 · Cited by 141 · see citing works
Self-citation
- Authors
- Ikegaya, Y., Aaron, G., Cossart, R., Aronov, D., Lampl, I., Ferster, D., & Yuste, R.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Ikegaya, Yuji
- Aaron, Gloster
- Yuste, Rafael
- Venue
- Science
- Published
- 2004-04-23
- Volume
- 304
- Issue
- 5670
- Pages
- 559-564
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064869244
- Cited by
- 838
- References
- 34
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 20 · 2023: 33 · 2022: 26 · 2021: 26 · 2020: 24 · 2019: 49 · 2018: 21 · 2017: 24 · 2016: 42 · 2015: 43 · 2014: 39 · 2013: 50 · 2012: 41
- FWCI
- 27.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- synfire chains, spontaneous neuronal activity, neocortical neurons, calcium imaging, temporal dynamics, stochastic synapses
- MeSH terms
- Action Potentials, Animals, Benzazepines, Calcium, Cats, Mice, Inbred C57BL, Nerve Net, Synaptic Transmission, Neurons, Synapses, Time Factors, Visual Cortex, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Prefrontal Cortex, Receptors, Dopamine D1, Pyramidal Cells, Patch-Clamp Techniques, Microscopy, Confocal, Excitatory Postsynaptic Potentials, Mice, In Vitro Techniques
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