Cited by 838Neural dynamics and brain functionMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Synfire Chains and Cortical Songs: Temporal Modules of Cortical Activity

Ikegaya, Yuji, Aaron, Gloster, Cossart, Rosa, Aronov, Dmitriy, Lampl, Ilan, Ferster, David, Yuste, Rafael·2004·Science

Abstract

How can neural activity propagate through cortical networks built with weak, stochastic synapses? We find precise repetitions of spontaneous patterns of synaptic inputs in neocortical neurons in vivo and in vitro. These patterns repeat after minutes, maintaining millisecond accuracy. Calcium imaging of slices reveals reactivation of sequences of cells during the occurrence of repeated intracellular synaptic patterns. The spontaneous activity drifts with time, engaging different cells. Sequences of active neurons have distinct spatial structures and are repeated in the same order over tens of seconds, revealing modular temporal dynamics. Higher order sequences are replayed with compressed timing.

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Crossref · 10.1126/science.1093173

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Authors
Ikegaya, Y., Aaron, G., Cossart, R., Aronov, D., Lampl, I., Ferster, D., & Yuste, R.
Affiliations
Northwestern University (US)
Corresponding author
  • Ikegaya, Yuji
  • Aaron, Gloster
  • Yuste, Rafael
Venue
Science
Published
2004-04-23
Volume
304
Issue
5670
Pages
559-564
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2064869244
Cited by
838
References
34
Citations by year
2026: 11 · 2025: 17 · 2024: 20 · 2023: 33 · 2022: 26 · 2021: 26 · 2020: 24 · 2019: 49 · 2018: 21 · 2017: 24 · 2016: 42 · 2015: 43 · 2014: 39 · 2013: 50 · 2012: 41
FWCI
27.36
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
synfire chains, spontaneous neuronal activity, neocortical neurons, calcium imaging, temporal dynamics, stochastic synapses
MeSH terms
Action Potentials, Animals, Benzazepines, Calcium, Cats, Mice, Inbred C57BL, Nerve Net, Synaptic Transmission, Neurons, Synapses, Time Factors, Visual Cortex, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Prefrontal Cortex, Receptors, Dopamine D1, Pyramidal Cells, Patch-Clamp Techniques, Microscopy, Confocal, Excitatory Postsynaptic Potentials, Mice, In Vitro Techniques

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