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Locally Synchronized Synaptic Inputs
Open accessAbstract
Synaptic inputs on dendrites are nonlinearly converted to action potential outputs, yet the spatiotemporal patterns of dendritic activation remain to be elucidated at single-synapse resolution. In rodents, we optically imaged synaptic activities from hundreds of dendritic spines in hippocampal and neocortical pyramidal neurons ex vivo and in vivo. Adjacent spines were frequently synchronized in spontaneously active networks, thereby forming dendritic foci that received locally convergent inputs from presynaptic cell assemblies. This precise subcellular geometry manifested itself during N-methyl-D-aspartate receptor-dependent circuit remodeling. Thus, clustered synaptic plasticity is innately programmed to compartmentalize correlated inputs along dendrites and may reify nonlinear synaptic integration.
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Metadata
- Authors
- Takahashi, N., Kitamura, K., Matsuo, N., Mayford, M., Kano, M., Matsuki, N., & Ikegaya, Y.
- Affiliations
- The University of Tokyo (JP)
- Japan Science and Technology Agency (JP)
- Kyoto University (JP)
- Scripps Research Institute (US)
- Corresponding author
- Ikegaya, Yuji
- Venue
- Science
- Published
- 2012-01-20
- Volume
- 335
- Issue
- 6066
- Pages
- 353-356
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2019251983
- Cited by
- 352
- References
- 37
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 37 · 2023: 21 · 2022: 16 · 2021: 26 · 2020: 17 · 2019: 17 · 2018: 22 · 2017: 20 · 2016: 25 · 2015: 26 · 2014: 31 · 2013: 27 · 2012: 27
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- green
- pure.teikyo.jp
- Licence
- cc-by-nc-nd
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Funders
- Japan Society for the Promotion of Science (22390012, 21220006, 23115504, 22680031, 22650083, 21680027, 23650204)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dendritic spines, dendritic integration, pyramidal neurons, hippocampus, neocortex, spontaneous network activity
- MeSH terms
- Action Potentials, Animals, Calcium, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neuronal Plasticity, Organ Culture Techniques, Somatosensory Cortex, Synapses, Receptors, N-Methyl-D-Aspartate, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Dendritic Spines, Mice, Rats, CA3 Region, Hippocampal
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