The Molecular Diversity of Adaptive Convergence
Abstract
Natural Selection Caught in the Act: Understanding how new functions evolve has been of long-standing interest. However, the number of mutations needed to evolve a key innovation is rarely known, or whether other sets of mutations would also suffice, whether the intermediate steps are driven by natural selection, or how contingent the outcome is on steps along the way. Meyer et al. (p. 428 ; see the Perspective by Thompson ) answer these questions for a case in which phage lambda evolved the ability to infect its host Escherichia coli through a novel receptor. This shift required four mutations, which accumulated under natural selection in concert with coevolution of the host. However, when Tenaillon et al. (p. 457 ) exposed 115 lines of E. coli to high temperature and sequenced them, adaptation occurred through many different genetic paths, showing parallelism at the level of genes and interacting protein complexes, but only rarely at the nucleotide level. Thus, epistasis—nonadditive genetic interaction—is likely to play an important part in the process of adaptation to this environment.
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Heat-inducible genes, including hslT, fkpA and gapA, showed adaptive expression changes during prolonged exposure to increased temperature in E. coli.
“Riehle and co-workers reported that heat-inducible genes, including hslT, fkpA and gapA, showed adaptive expression changes during prolonged exposure to increased temperature [78].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [78]
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- Authors
- Tenaillon, O., Rodríguez-Verdugo, A., Gaut, R. L., McDonald, P., Bennett, A. F., Long, A. D., & Gaut, B. S.
- Affiliations
- Inserm (FR)
- Department of Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, CA 92697, USA.
- University of California, Irvine (US)
- Corresponding author
- Tenaillon, Olivier
- Long, Anthony D.
- Gaut, Brandon S.
- Venue
- Science
- Published
- 2012-01-27
- Volume
- 335
- Issue
- 6067
- Pages
- 457-461
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006492816
- Cited by
- 815
- References
- 48
- Citations by year
- 2026: 32 · 2025: 38 · 2024: 83 · 2023: 50 · 2022: 49 · 2021: 95 · 2020: 47 · 2019: 54 · 2018: 58 · 2017: 67 · 2016: 55 · 2015: 52 · 2014: 61 · 2013: 50 · 2012: 24
- FWCI
- 36.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (DEB-0748903)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- adaptive convergence, bacteriophage lambda, Escherichia coli, receptor evolution, host-pathogen coevolution, epistasis, parallel evolution, thermal adaptation, molecular evolution, natural selection
- MeSH terms
- Adaptation, Physiological, Epistasis, Genetic, Escherichia coli, Genes, Bacterial, Models, Genetic, Mutation, Operon, Rho Factor, DNA-Directed RNA Polymerases, Selection, Genetic, Temperature, Genome, Bacterial, Point Mutation, Sequence Deletion, Sequence Analysis, DNA, Evolution, Molecular, Genetic Fitness
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