Cited by 25Evolution and Genetic DynamicsGenomics and Phylogenetic StudiesMicrobial Metabolic Engineering and Bioproduction

Microbial evolution in vivo and in silico: methods and applications

Mozhayskiy, Vadim, Tagkopoulos, Ilias·2013·Integr. Biol.

Abstract

Microbial evolution has been extensively studied in the past fifty years, which has lead to seminal discoveries that have shaped our understanding of evolutionary forces and dynamics. It is only recently however, that transformative technologies and computational advances have enabled a larger in-scale and in-depth investigation of the genetic basis and mechanistic underpinnings of evolutionary adaptation. In this review we focus on the strengths and limitations of in vivo and in silico techniques for studying microbial evolution in the laboratory, and we discuss how these complementary approaches can be integrated in a unifying framework for elucidating microbial evolution.

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Crossref · 10.1039/c2ib20095c

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141 of 141 references verified0 citation errors · 0 not checkable

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  • During adaptive evolution, certain trait values change and are associated with increased Darwinian fitness; an improved phenotype or property is often equal to increased fitness.

    “During adaptive evolution, certain trait values change and are associated with increased (Darwinian) fitness [20]; as such, an improved phenotype or property is often equal to increased fitness.”

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Authors
Mozhayskiy, V., & Tagkopoulos, I.
Affiliations
University of California, Davis (US)
Corresponding author
Tagkopoulos, Ilias
Venue
Integr. Biol.
Published
2013
Volume
5
Issue
2
Pages
262-277
ISSN
  • 1757-9694 (ISSN-L)
  • 1757-9708
OpenAlex
W2144526734
Cited by
24
References
140
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 2
FWCI
0.28
Type
journal article
Language
en
Open access
closed
Locations
  • Integrative Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of California, Davis
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords
microbial evolution, in vivo evolution, in silico evolution, experimental evolution, adaptive evolution, genetic basis of adaptation
MeSH terms
Bacteria, Bacterial Proteins, Computer Simulation, Biological Evolution, Models, Genetic, Mutation

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