Programmable materials and the nature of the DNA bond
Abstract
For over half a century, the biological roles of nucleic acids as catalytic enzymes, intracellular regulatory molecules, and the carriers of genetic information have been studied extensively. More recently, the sequence-specific binding properties of DNA have been exploited to direct the assembly of materials at the nanoscale. Integral to any methodology focused on assembling matter from smaller pieces is the idea that final structures have well-defined spacings, orientations, and stereo-relationships. This requirement can be met by using DNA-based constructs that present oriented nanoscale bonding elements from rigid core units. Here, we draw analogy between such building blocks and the familiar chemical concepts of "bonds" and "valency" and review two distinct but related strategies that have used this design principle in constructing new configurations of matter.
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DNA and RNA nanotechnologies have been applied to deliver RNA therapeutics such as siRNA and miRNA, mainly for cancer therapy.
“In addition to viral vectors, DNA and RNA nanotechnologies have also been applied to deliver RNA therapeutics such as siRNA and miRNA, which are mainly used for cancer therapy.[24, 29–33]”
From RNA delivery biomaterials for the treatment of genetic and rare diseases (2019) · cites this paper as [29]
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- Authors
- Jones, M. R., Seeman, N. C., & Mirkin, C. A.
- Affiliations
- Northwestern University (US)
- New York University (US)
- Corresponding author
- Seeman, Nadrian C.
- Mirkin, Chad A.
- Venue
- Science
- Published
- 2015-02-20
- Volume
- 347
- Issue
- 6224
- Pages
- 1260901-1260901
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2019403558
- Cited by
- 1,347
- References
- 113
- Citations by year
- 2026: 45 · 2025: 68 · 2024: 91 · 2023: 107 · 2022: 112 · 2021: 137 · 2020: 128 · 2019: 139 · 2018: 178 · 2017: 153 · 2016: 127 · 2015: 62
- FWCI
- 16.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- National Science Foundation (CMMI-1120890, EFRI-1332411, CCF-1117210)
- Office of Naval Research (N000141110729, N000140911118)
- U.S. Department of Energy (DE-SC0007991)
- Air Force Office of Scientific Research (FA9550-11-1-0275)
- Army Research Office (W911NF-11-1-0024)
- Gordon and Betty Moore Foundation (3849)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- DNA nanotechnology, programmable materials, sequence-specific DNA binding, nanoscale assembly, valence, DNA origami, self-assembly, nanomaterials
- MeSH terms
- DNA, Nucleic Acid Conformation, Nucleic Acid Hybridization, Nanostructures
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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