The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS
Open accessAbstract
TACE Trafficking: The cytokine tumor necrosis factor (TNF) is a major driver of inflammation and contributes to the immune pathology seen in a variety of diseases, including inflammatory bowel disease, rheumatoid arthritis, and sepsis. Soluble TNF is produced by cleavage of its ectodomain by the ADAM family metalloprotease, TNFα-converting enzyme (TACE). However, the molecular regulation of TACE is not understood (see the Perspective by Lichtenthaler ). Adrain et al. (p. 225 ) and McIlwain et al. (p. 229 ) now show that the rhomboid family member iRhom2 interacts with TACE in macrophages and is required for its proper intracellular trafficking and activation. In the absence of iRhom2, TACE was not released from the endoplasmic reticulum, and active protease did not reach the cell surface. Because of an inability to produce TNF, iRhom2-deficient mice were more resistant to lipopolysaccharide-induced septic shock but could not adequately control a Listeria monocytogenes infection.
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A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149
Pfeffer, K., Matsuyama, T., Kündig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Krönke, M., & Mak, T. W. (1993) · Cell · doi:10.1016/0092-8674(93)90134-c · Cited by 1,677
Self-citationIncreased susceptibility to bacterial superinfection as a consequence of innate antiviral responses
Navarini, A. A., Recher, M., Lang, K. S., Georgiev, P., Meury, S., Bergthaler, A., Flatz, L., Bille, J., Landmann, R., Odermatt, B., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607325103 · Cited by 144
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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
De Jager, P. L., Srivastava, G., Lunnon, K., Burgess, J., Schalkwyk, L. C., Yu, L., Eaton, M. L., Keenan, B. T., Ernst, J., McCabe, C., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3786 · Cited by 956
“Absence of RHBDF2 in mice impacts the normal release of TNF α from the cell surface 34 and impairs systemic immune responses to pathogens 35 .”
Regulation of tumour necrosis factor signalling: live or let die
Brenner, D., Blaser, H., & Mak, T. W. (2015) · Nature Reviews Immunology · doi:10.1038/nri3834 · Cited by 998
Self-citationMetalloproteinases and their natural inhibitors in inflammation and immunity
Khokha, R., Murthy, A., & Weiss, A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3499 · Cited by 552
Lichtenthaler, S. F., Lemberg, M. K., & Fluhrer, R. (2018) · The EMBO Journal · doi:10.15252/embj.201899456 · Cited by 323
The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles
Freeman, M. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-012944 · Cited by 145
Metadata
- Authors
- McIlwain, D. R., Lang, P. A., Maretzky, T., Hamada, K., Ohishi, K., Maney, S. K., Berger, T., Murthy, A., Duncan, G., Xu, H. C., Lang, K. S., Häussinger, D., Wakeham, A., Itie-Youten, A., Khokha, R., Ohashi, P. S., Blobel, C. P., & Mak, T. W.
- Venue
- Science
- Published
- 2012-01-13
- Volume
- 335
- Issue
- 6065
- Pages
- 229-232
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983146096
- Cited by
- 327
- References
- 3
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- green
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