Cited by 512Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsSubstance Abuse Treatment and Outcomes

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A Memory Retrieval-Extinction Procedure to Prevent Drug Craving and Relapse

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Xue, Yan-Xue, Luo, Yi-Xiao, Wu, Ping, Shi, Hai-Shui, Xue, Li-Fen, Chen, Chen, Zhu, Wei-Li, Ding, Zeng-Bo, Bao, Yan-ping, Shi, Jie, Epstein, David H., Shaham, Yavin, Lu, Lin·2012·Science

DOI 10.1126/science.1215070PMC PMC3695463

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Abstract

Disrupting Drug Memories: In drug recovery programs, conditioned responses to drug cues can be inhibited by extinction protocols. However, extinguished behavioral responses can return after renewed exposure to the drug itself, or to drug-associated paraphernalia, and sometimes these responses reemerge spontaneously. Attempts have been made to disrupt cue-memory reconsolidation or to strengthen extinction learning, but these efforts have often relied on pharmacological agents that either are not approved for human use or cause problematic side effects. Xue et al. (p. 241 ; see the Perspective by Milton and Everitt ) have tried to circumvent the limitations of pharmacological approaches in daily retrieval trials conducted in rats within the short timeframe of the “reconsolidation window” before the extinction sessions reduced drug-induced reinstatement, spontaneous recovery, and renewal of drug seeking. When translated to heroin-addicted humans, similar retrieval trials before extinction sessions impaired cue-induced heroin craving up to 6 months later. This retrieval-extinction procedure is thus a promising non-pharmacological treatment for addiction.

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Authors: Xue, Y.-X., Luo, Y.-X., Wu, P., Shi, H.-S., Xue, L.-F., Chen, C., Zhu, W.-L., Ding, Z.-B., Bao, Y.-P., Shi, J., Epstein, D. H., Shaham, Y., & Lu, L.
Affiliations: Peking University (CN)
National Institute on Drug Dependence, Peking University, Beijing 100191, China.
National Institutes of Health (US)
Corresponding author: Xue, Yan-Xue
Wu, Ping
ORCID: Xue, Yan-Xue
Wu, Ping
Shi, Jie
Epstein, David H.
Shaham, Yavin
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2012-04-13
Volume: 336
Issue: 6078
Pages: 241-245
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1215070
PMC: PMC3695463
OpenAlex: W2077594514
Cited by: 511
References: 62
Citations by year: 2026: 21 · 2025: 26 · 2024: 25 · 2023: 23 · 2022: 34 · 2021: 33 · 2020: 34 · 2019: 27 · 2018: 44 · 2017: 36 · 2016: 43 · 2015: 42 · 2014: 46 · 2013: 56 · 2012: 21
FWCI: 21.75
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (Z99 DA999999)
National Institute on Drug Abuse (ZIADA000434)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: memory retrieval, extinction, drug craving, relapse prevention, heroin addiction, drug-associated memory, reinstatement, renewal, spontaneous recovery, drug-seeking behavior, cue-induced craving, abstinence, non-pharmacological treatment
MeSH terms: Amygdala, Animals, Cocaine, Conditioning, Classical, Conditioning, Operant, Cues, Heroin, Extinction, Psychological, Heroin Dependence, Humans, Male, Memory, Protein Kinase C, Mental Recall, Recurrence, Self Administration, Time Factors, Behavior, Addictive, Rats, Sprague-Dawley, Prefrontal Cortex, Cocaine-Related Disorders, Models, Animal, Rats

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A Memory Retrieval-Extinction Procedure to Prevent Drug Craving and Relapse

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