The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Stem Cell–Based Approach to Cartilage Repair
Abstract
Osteoarthritis and Kartogenin: Osteoarthritis is characterized by progressive breakdown of articular cartilage and affects over 25 million people in the United States. Mesenchymal stem cells (MSCs), which reside in healthy and diseased joints, are multipotent adult stem cells that are able to differentiate into a variety of cell types. Johnson et al. (p. 717 , published online 5 April) identified a small molecule, kartogenin, which was able to induce MSCs to differentiate into chondrocytes in vitro. When administered locally, kartogenin was efficacious in two animal models of osteoarthritis.
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Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Signaling networks in RUNX2‐dependent bone development
Komori, T. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22994 · Cited by 329
Cited by
Glyn-Jones, S., Palmer, A. J. R., Agricola, R., Price, A. J., Vincent, T. L., Weinans, H., & Carr, A. J. (2015) · The Lancet · doi:10.1016/s0140-6736(14)60802-3 · Cited by 3,151
Mesenchymal stromal cells: new directions
Keating, A. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.015 · Cited by 778
Cell-laden hydrogels for osteochondral and cartilage tissue engineering
Yang, J., Zhang, Y. S., Yue, K., & Khademhosseini, A. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.036 · Cited by 652
Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095919 · Cited by 462
Image-based profiling for drug discovery: due for a machine-learning upgrade?
Chandrasekaran, S. N., Ceulemans, H., Boyd, J. D., & Carpenter, A. E. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00117-w · Cited by 389
Metadata
- Authors
- Johnson, K., Zhu, S., Tremblay, M. S., Payette, J. N., Wang, J., Bouchez, L. C., Meeusen, S., Althage, A., Cho, C. Y., Wu, X., & Schultz, P. G.
- Venue
- Science
- Published
- 2012-05-11
- Volume
- 336
- Issue
- 6082
- Pages
- 717-721
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2142801671
- Cited by
- 796
- References
- 2
- FWCI
- 32.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Johnson, K., Zhu, S., Tremblay, M. S., Payette, J. N., Wang, J., Bouchez, L. C., Meeusen, S., Althage, A., Cho, C. Y., Wu, X., & Schultz, P. G. (2012). A Stem Cell–Based Approach to Cartilage Repair. Science. https://doi.org/10.1126/science.1215157
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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