The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target
Open accessAbstract
Wrapped DNA: TAL effectors are proteins that bacterial pathogens inject into plant cells that bind to host DNA to activate expression of plant genes. The DNA-binding domain of TAL proteins is composed of tandem repeats within which a repeat-variable diresidue sequence confers nucleotide specificity. Deng et al. (p. 720 , published online 5 January) report the structure of the TAL effector dHax3, containing 11.5 repeats, in DNA-free and DNA-bound states, and Mak et al. (p. 716 , published online 5 January) report the structure of the PthXo1 TAL effector, containing 22 repeats, bound to its DNA target. Together, the structures reveal the conformational changes involved in DNA binding and provide the structural basis of DNA recognition.
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TAL effectors: customizable proteins for DNA targeting
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TALENs: A widely applicable technology for targeted genome editing
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“26, 27 Nearly all engineered TALE repeat arrays published to date use four domains with the hypervariable residues NN, NI, HD and NG, for the recognition of G, A, C, and T, respectively.”
A guide to genome engineering with programmable nucleases
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Metadata
- Authors
- Mak, A. N.-S., Bradley, P., Cernadas, R. A., Bogdanove, A. J., & Stoddard, B. L.
- Venue
- Science
- Published
- 2012-02-10
- Volume
- 335
- Issue
- 6069
- Pages
- 716-719
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083582836
- Cited by
- 569
- References
- 7
- FWCI
- 28.11
- Type
- journal article
- Language
- en
- Open access
- green
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