The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels
Abstract
Bio-Inspired Drug Delivery: Noting that platelets naturally migrate to narrowed blood vessels characterized by high fluid shear stress, Korin et al. (p. 738 , published online 5 July; see the Perspective by Lavik and Ustin ) developed a nanoparticle-based therapeutic that uses a similar targeting mechanism to deliver a drug to vessels obstructed by blood clots. Aggregates of nanoparticles coated with the clot-dissolving drug tPA (tissue plasminogen activator) were designed to fall apart and release the drug only when encountering high fluid shear stress. In preclinical models, the bio-inspired therapeutic dissolved clots and restored normal blood flow at lower doses than free tPA, suggesting that this localized delivery system may help reduce the risk of side effects such as excessive bleeding.
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Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250
Self-citationMortality by cause for eight regions of the world: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07493-4 · Cited by 4,043
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Bhise, N. S., Ribas, J., Manoharan, V., Zhang, Y. S., Polini, A., Massa, S., Dokmeci, M. R., & Khademhosseini, A. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.004 · Cited by 381
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Supraparticles: Functionality from Uniform Structural Motifs
Wintzheimer, S., Granath, T., Oppmann, M., Kister, T., Thai, T., Kraus, T., Vogel, N., & Mandel, K. (2018) · ACS Nano · doi:10.1021/acsnano.8b00873 · Cited by 253
The blood clearance kinetics and pathway of polymeric micelles in cancer drug delivery
Sun, X., Wang, G., Zhang, H., Hu, S., Liu, X., Tang, J., & Shen, Y. (2018) · ACS Nano · doi:10.1021/acsnano.8b02830 · Cited by 253
Metadata
- Authors
- Korin, N., Kanapathipillai, M., Matthews, B. D., Crescente, M., Brill, A., Mammoto, T., Ghosh, K., Jurek, S., Bencherif, S. A., Bhatta, D., Coskun, A. U., Feldman, C. L., Wagner, D. D., & Ingber, D. E.
- Venue
- Science
- Published
- 2012-08-10
- Volume
- 337
- Issue
- 6095
- Pages
- 738-742
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006474652
- Cited by
- 540
- References
- 2
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Korin, N., Kanapathipillai, M., Matthews, B. D., Crescente, M., Brill, A., Mammoto, T., Ghosh, K., Jurek, S., Bencherif, S. A., Bhatta, D., Coskun, A. U., Feldman, C. L., Wagner, D. D., & Ingber, D. E. (2012). Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels. Science. https://doi.org/10.1126/science.1217815
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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