Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling
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In recent years, advances in tissue engineering and microfabrication technologies have enabled rapid growth in the areas of in vitro organoid development as well as organoid-on-a-chip platforms. These 3D model systems often are able to mimic human physiology more accurately than traditional 2D cultures and animal models. In this review, we describe the progress that has been made to generate organ-on-a-chip platforms and, more recently, more complex multi-organoid body-on-a-chip platforms and their applications. Importantly, these systems have the potential to dramatically impact biomedical applications in the areas of drug development, drug and toxicology screening, disease modeling, and the emerging area of personalized precision medicine.
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3D tissue models, such as in vitro tissue-engineered disease models, have shown promise for overcoming obstacles faced with 2D cultured cells and animal models.
“3D tissue models, such as in vitro tissue-engineered disease models have shown promise for addressing the current obstacles faced with 2D in vitro cultured cells and animal models [352–356].”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [355]
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Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening
Du, Y., Li, X., Niu, Q., Mo, X., Qui, M., Ma, T., Kuo, C. J., & Fu, H. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa036 · Cited by 125 · see citing works
Iliuţă, M.-E., Moisescu, M.-A., Pop, E., Ionita, A.-D., Caramihai, S.-I., & Mitulescu, T.-C. (2024) · Applied Sciences · doi:10.3390/app14135454 · Cited by 134 · see citing works
Applications of tumor chip technology
Hachey, S. J., & Hughes, C. C. W. (2018) · Lab on a Chip · doi:10.1039/c8lc00330k · Cited by 128 · see citing works
In Vitro Strategies to Vascularize 3D Physiologically Relevant Models
Dellaquila, A., Le Bao, C., Letourneur, D., & Simon‐Yarza, T. (2021) · Advanced Science · doi:10.1002/advs.202100798 · Cited by 115 · see citing works
Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation
Park, D., Lee, J., Chung, J. J., Jung, Y., & Kim, S. H. (2020) · Trends in Biotechnology · doi:10.1016/j.tibtech.2019.06.006 · Cited by 105 · see citing works
InVADE: integrated vasculature for assessing dynamic events
Lai, B. F. L., Huyer, L. D., Lu, R. X. Z., Drecun, S., Radisic, M., & Zhang, B. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201703524 · Cited by 97 · see citing works
Wang, Y., Wu, D., Wu, G., Wu, J., Lu, S., Lo, J., He, Y., Zhao, C., Zhao, X., Zhang, H., et al. (2020) · Theranostics · doi:10.7150/thno.38736 · Cited by 93 · see citing works
Advanced human developmental toxicity and teratogenicity assessment using human organoid models
Li, M., Gong, J., Gao, L., Zou, T., Kang, J., & Xu, H. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113429 · Cited by 84 · see citing works
Bioprinting technologies for disease modeling
Memic, A., Navaei, A., Mirani, B., Cordova, J. A. V., Aldhahri, M., Dolatshahi-Pirouz, A., Akbari, M., & Nikkhah, M. (2017) · Biotechnology Letters · doi:10.1007/s10529-017-2360-z · Cited by 73 · see citing works
Bioprinting and organ-on-chip applications towards personalized medicine for bone diseases
Arrigoni, C., Gilardi, M., Bersini, S., Candrian, C., & Moretti, M. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9741-5 · Cited by 68 · see citing works
Liver–heart on chip models for drug safety
Ferrari, E., & Rasponi, M. (2021) · APL Bioengineering · doi:10.1063/5.0048986 · Cited by 53 · see citing works
Novelli, G., Spitalieri, P., Murdocca, M., Centanini, E., & Sangiuolo, F. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1059579 · Cited by 43 · see citing works
Advances in microfluidic 3D cell culture for preclinical drug development
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- Authors
- Skardal, A., Shupe, T., & Atala, A.
- Affiliations
- Atrium Health Wake Forest Baptist (US)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Skardal, Aleksander
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 21
- Issue
- 9
- Pages
- 1399-1411
- ISSN
- 1359-6446 (ISSN-L)
- PMC
- PMC9039871
- OpenAlex
- W2500581099
- Cited by
- 512
- References
- 85
- Citations by year
- 2026: 33 · 2025: 44 · 2024: 48 · 2023: 44 · 2022: 49 · 2021: 70 · 2020: 58 · 2019: 57 · 2018: 57 · 2017: 43 · 2016: 8
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R21CA229027)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Keywords
- organoids, organ-on-a-chip, body-on-a-chip, drug screening, drug toxicity testing, disease modeling, 3D tissue models, personalized medicine, microfabrication, tissue engineering
- MeSH terms
- Drug Evaluation, Preclinical, Humans, Models, Biological, Organoids, Tissue Engineering
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