The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization
Open accessAbstract
The Real McCoy: Some secreted proteins are phosphorylated, the most prominent example being the milk protein casein, but the enzymes that catalyze such phosphorylation have not been identified. (The proteins known as “casein kinases” are in fact cytosolic proteins and do not mediate physiological phosphorylation of casein.) Tagliabracci et al. (p. 1150 , published online 10 May) searched for a human protein with the characteristics expected of a secretory protein kinase and identified Fam20C. Mutations in the gene encoding Fam20C cause defects in bone formation. Furthermore, the consensus sequence for Fam20C phosphorylation was found in several secreted proteins that function in biomineralization. Thus, Fam20C appears to be the “real” casein kinase and to function in bone physiology.
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Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
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Schumacher, M. A., Piro, K. M., Xu, W., Hansen, S., Lewis, K., & Brennan, R. G. (2009) · Science · doi:10.1126/science.1163806 · Cited by 351
Kawasaki, K., & Weiss, K. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0638023100 · Cited by 314
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Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny
Cappellini, E., Welker, F., Pandolfi, L., Ramos-Madrigal, J., Samodova, D., Rüther, P. L., Fotakis, A. K., Lyon, D., Moreno-Mayar, J. V., Bukhsianidze, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1555-y · Cited by 205
Metadata
- Authors
- Tagliabracci, V. S., Engel, J. L., Wen, J., Wiley, S. E., Worby, C. A., Kinch, L. N., Xiao, J., Grishin, N. V., & Dixon, J. E.
- Venue
- Science
- Published
- 2012-06
- Volume
- 336
- Issue
- 6085
- Pages
- 1150-1153
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040328099
- Cited by
- 480
- References
- 3
- FWCI
- 30.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Tagliabracci, V. S., Engel, J. L., Wen, J., Wiley, S. E., Worby, C. A., Kinch, L. N., Xiao, J., Grishin, N. V., & Dixon, J. E. (2012). Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization. Science. https://doi.org/10.1126/science.1217817
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