The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Vitamin K 2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency
Open accessAbstract
Keeping Mitochondria in the Pink: Pink1 is a mitochondrial kinase, and loss of Pink1 function in flies and mice results in the accumulation of inefficient mitochondria. In a screen for modifiers of the Parkinson-associated gene, pink1 , Vos et al. (p. 1306 , published online 10 May; see the Perspective by Bhalerao and Clandinin ) identified the fruit fly homolog of UBIAD1, “Heix.” UBIAD1 was localized in mitochondria and was able to convert vitamin K 1 into vitamin K 2 /menaquinone (MK- n, n the number of prenylgroups). In bacteria, vitamin K 2 /MK- n acts as an electron carrier in the membrane and, similarly, in Drosophila , mitochondrial vitamin K 2 appeared to act as an electron carrier to facilitate adenosine triphosphate production. Fruit flies that lack heix showed severe mitochondrial defects that could be rescued by administering vitamin K 2 .
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Cites
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705
Verstreken, P., Ly, C. V., Venken, K. J. T., Koh, T.-W., Zhou, Y., & Bellen, H. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.018 · Cited by 841
Self-citationMcCarthy, S., Somayajulu, M., Sikorska, M., Borowy-Borowski, H., & Pandey, S. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.04.019 · Cited by 248
Cited by
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
Pickrell, A. M., & Youle, R. J. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.007 · Cited by 2,310
Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., et al. (2017) · Movement Disorders · doi:10.1002/mds.27115 · Cited by 859
“Drosophila identified vitamin K2 as a suppressor of the PINK1 mutant phenotype, which functions as an electron carrier molecule in mitochondria leading to improved ATP production.(167) It has thus been hypothesized that stratifying PD patients according to different degrees of mitochondrial dysfunction based on their…”
Romano, S., Savva, G. M., Bedarf, J. R., Charles, I. G., Hildebrand, F., & Narbad, A. (2021) · npj Parkinson's Disease · doi:10.1038/s41531-021-00156-z · Cited by 707
Excitotoxicity: Bridge to various triggers in neurodegenerative disorders
Mehta, A., Prabhakar, M., Kumar, P., Deshmukh, R., & Sharma, P. L. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.10.032 · Cited by 665
Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease
Ryan, B. J., Hoek, S., Fon, E. A., & Wade-Martins, R. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.02.003 · Cited by 524
Metadata
- Authors
- Vos, M., Esposito, G., Edirisinghe, J. N., Vilain, S., Haddad, D. M., Slabbaert, J. R., Van Meensel, S., Schaap, O., De Strooper, B., Meganathan, R., Morais, V. A., & Verstreken, P.
- Venue
- Science
- Published
- 2012-06-08
- Volume
- 336
- Issue
- 6086
- Pages
- 1306-1310
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042264135
- Cited by
- 363
- References
- 5
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Vitamin K 2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency. https://app.cochat.ai/papers/10.1126/science.1218632
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- Vos, M., Esposito, G., Edirisinghe, J. N., Vilain, S., Haddad, D. M., Slabbaert, J. R., Van Meensel, S., Schaap, O., De Strooper, B., Meganathan, R., Morais, V. A., & Verstreken, P. (2012). Vitamin K 2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency. Science. https://doi.org/10.1126/science.1218632
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
