Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble Coenzyme Q10

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673 · see citing works

Translating cell biology into therapeutic advances in Alzheimer's disease

Selkoe, D. J. (1999) · Nature · doi:10.1038/399a023 · Cited by 1,588 · see citing works

Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production

Li, N., Ragheb, K., Lawler, G., Sturgis, J., Rajwa, B. P., Melendez, J. A., & Robinson, J. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210432200 · Cited by 1,434 · see citing works

Mitochondrial reactive oxygen species in cell death signaling

Fleury, C., Mignotte, B., & Vayssière, J. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01369-x · Cited by 1,069 · see citing works

Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples

Baker, M. A., Cerniglia, G. J., & Zaman, A. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90208-q · Cited by 921 · see citing works

Environmental Risk Factors and Parkinson's Disease: Selective Degeneration of Nigral Dopaminergic Neurons Caused by the Herbicide Paraquat

McCormack, A. L., Thiruchelvam, M. J., Manning-Bog, A., Thiffault, C., Langston, J. W., Cory‐Slechta, D. A., & Monte, D. A. D. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0507 · Cited by 838 · see citing works

Sequential Treatment of SH‐SY5Y Cells with Retinoic Acid and Brain‐Derived Neurotrophic Factor Gives Rise to Fully Differentiated, Neurotrophic Factor‐Dependent, Human Neuron‐Like Cells

Encinas, M., Iglesias, M., Liu, Y., Wang, H., Muhaisen, A., Ceña, V., Gallego, C., & Comella, J. X. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750991.x · Cited by 822 · see citing works

Mitochondrial disease in mouse results in increased oxidative stress

Esposito, L., Melov, S., Panov, A. V., Cottrell, B. A., & Wallace, D. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4820 · Cited by 637 · see citing works

Environmental risk factors and Parkinson's disease

Liou, H., Tsai, M.-C., Chen, C., Jeng, J., Chang, Y. C., Chen, S. Y., & Chen, R.-T. (1997) · Neurology · doi:10.1212/wnl.48.6.1583 · Cited by 616 · see citing works

Prospects for new restorative and neuroprotective treatments in Parkinson's disease

Dunnett, S. B., & Björklund, A. (1999) · Nature · doi:10.1038/399a032 · Cited by 539 · see citing works

Untitled work

Selkoe (1999) · doi:10.1038/19866 · Cited by 468 · see citing works

Coenzyme Q10 Prevents Apoptosis by Inhibiting Mitochondrial Depolarization Independently of Its Free Radical Scavenging Property

Papucci, L., Schiavone, N., Witort, E. J., Donnini, M., Lapucci, A., Tempestini, A., Formigli, L., Zecchi‐Orlandini, S., Orlandini, G., Carella, G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302297200 · Cited by 303 · see citing works

Age‐related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype

Thiruchelvam, M. J., McCormack, A. L., Richfield, E. K., Baggs, R. B., Tank, A. W., Monte, D. A. D., & Cory‐Slechta, D. A. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02781.x · Cited by 280 · see citing works

Apoptosis: Molecular Control Point in Toxicity

Corcoran, G. B., Fix, L. N., Jones, D., Moslen, M. T., Nicotera, P., Oberhammer, F., & Buttyan, R. (1994) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1994.1195 · Cited by 268 · see citing works

Carrier-mediated processes in blood–brain barrier penetration and neural uptake of paraquat

Shimizu, K., Ohtaki, K., Matsubara, K., Aoyama, K., Uezono, T., Saitô, O., Suno, M., Ogawa, K., Hayase, N., Kimura, K., et al. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02577-x · Cited by 264 · see citing works

Dopaminergic cell death induced by MPP+, oxidant and specific neurotoxicants shares the common molecular mechanism

Chun, H. S., Gibson, G. E., DeGiorgio, L. A., Zhang, H., Kidd, V. J., & Son, J. H. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00096.x · Cited by 256 · see citing works

Environmental Factors in Parkinson’s Disease

Monte, D. A. D., Lavasani, M., & Manning-Bog, A. (2002) · NeuroToxicology · doi:10.1016/s0161-813x(02)00099-2 · Cited by 241 · see citing works

Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death

Hickey, E. J., Raje, R. R., Reid, V. E., Gross, S. M., & Ray, S. D. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00560-3 · Cited by 220 · see citing works

Cell Suicide in Health and Disease

Duke, R. C., Ojcius, D. M., & Young, J. D. (1996) · Scientific American · doi:10.1038/scientificamerican1296-80 · Cited by 216 · see citing works

From entropy to Duino

Bignami, G. F. (1999) · Nature · doi:10.1038/19899 · Cited by 163 · see citing works

Risk-factors for Parkinson's disease: case-control study in the province of Cáceres, Spain

Morano, A. E., Jiménez‐Jiménez, F. J., Pérez-Molina, J. A., & Antolín, M. A. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1994.tb01655.x · Cited by 150 · see citing works

Thiram-induced cytotoxicity is accompanied by a rapid and drastic oxidation of reduced glutathione with consecutive lipid peroxidation and cell death

Cereser, C., Boget, S., Parvaz, P., & Revol, A. (2001) · Toxicology · doi:10.1016/s0300-483x(01)00401-2 · Cited by 143 · see citing works

Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes

Siraki, A. G., Pourahmad, J., Chan, T. S., Khan, S., & O'Brien, P. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00764-x · Cited by 122 · see citing works

Effects of Paraquat on the Substantia Nigra of the Wistar Rats: Neurochemical, Histological, and Behavioral Studies

Liou, H., Chen, R.-C., Tsai, Y.-F., Chen, W., Chang, Y.-C., & Tsai, M.-C. (1996) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.0054 · Cited by 105 · see citing works

The Epidemiology and Prevention of Paraquat Poisoning

Onyon, L., & Volans, G. N. (1987) · Human Toxicology · doi:10.1177/096032718700600104 · Cited by 103 · see citing works

Molecular mechanisms of glutamate neurotoxicity in mixed cultures of NT2‐derived neurons and astrocytes: Protective effects of coenzyme Q10

Sandhu, J. K., Pandey, S., Ribecco‐Lutkiewicz, M., Monette, R., Borowy‐Borowski, H., Walker, P. R., & Sikorska, M. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10579 · Cited by 88 · see citing works

New order from neurological disorders

Price, D. L. (1999) · Nature · doi:10.1038/399a003 · Cited by 82 · see citing works

Oxidative stress-induced apoptosis in dividing fibroblasts involves activation of p38 MAP kinase and over-expression of Bax: Resistance of quiescent cells to oxidative stress

Naderi, J., Hung, M.-Y., & Pandey, S. (2003) · APOPTOSIS · doi:10.1023/a:1021657220843 · Cited by 73 · see citing works

Paraquat: A Useful Tool for thein vivoStudy of Mechanisms of Neuronal Cell Death

Corasaniti, M. T., Strongoli, M. C., Rotiroti, D., Bagetta, G., & Nisticò, G. (1998) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1998.tb01434.x · Cited by 73 · see citing works

APOPTOSIS IN HUMAN LUNG EPITHELIAL CELLS: TRIGGERING BY PARAQUAT AND MODULATION BY ANTIOXIDANTS

Cappelletti, G., Maggioni, M. G., & Maci, R. (1998) · Cell Biology International · doi:10.1006/cbir.1998.0305 · Cited by 65 · see citing works

Oxidative stress and activation of proteasome protease during serum deprivation-induced apoptosis in rat hepatoma cells; inhibition of cell death by melatonin

Pandey, S., Lopez, C., & Jammu, A. (2003) · APOPTOSIS · doi:10.1023/a:1025542424986 · Cited by 63 · see citing works

An alpha-lipoic acid–vitamin E mixture reduces post-embolism lipid peroxidation, cerebral infarction, and neurological deficit in rats

Garcı́a‐Estrada, J., González-Pérez, Ó., González-Castañeda, R. E., Martínez-Contreras, A., Luquı́n, S., de la Mora, P. G., & Navarro-Ruiz, A. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(03)00200-1 · Cited by 47 · see citing works

Paraquat-induced phosphatidylserine oxidation and apoptosis are independent of activation of PLA2

Fabisiak, J. P., Kagan, V. E., Tyurina, Y. Y., Tyurin, V. A., & Lazo, J. S. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.5.l793 · Cited by 25 · see citing works

Reactive Oxygen Species-Induced Activation of the MAP Kinase Signaling Pathways

McCubrey, J. A., LaHair, M. M., & Franklin, R. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1775 · Cited by 804 · see citing works

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

Henchcliffe, C., & Beal, M. F. (2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0924 · Cited by 786 · see citing works

Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease

Misrani, A., Tabassum, S., & Yang, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.617588 · Cited by 654 · see citing works

Complex I Is the Major Site of Mitochondrial Superoxide Production by Paraquat

Cochemé, H. M., & Murphy, M. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708597200 · Cited by 563 · see citing works

Medical management of paraquat ingestion

Gawarammana, I., & Buckley, N. A. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.04026.x · Cited by 564 · see citing works

Mitochondrial Diseases of the Brain

Chaturvedi, R. K., & Beal, M. F. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.03.018 · Cited by 416 · see citing works

Vitamin K 2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency

Vos, M. H., Esposito, G., Edirisinghe, J. N., Vilain, S., Haddad, D., Slabbaert, J. R., Meensel, S. V., Schaap, O., Strooper, B. D., Meganathan, R., et al. (2012) · Science · doi:10.1126/science.1218632 · Cited by 364 · see citing works

Mitochondrial uncoupling proteins in the cns: in support of function and survival

Andrews, Z., Diano, S., & Horvath, T. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1767 · Cited by 380 · see citing works

Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System

Ren, X., Zou, L., Zhang, X., Branco, V., Wang, J., Carvalho, C. M. L., Holmgren, A., & Lu, J. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6925 · Cited by 365 · see citing works

Paraquat and Parkinson's disease

Berry, C. L., Vecchia, C. L., & Nicotera, P. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2009.217 · Cited by 309 · see citing works

Mitochondrial Approaches for Neuroprotection

Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294 · see citing works

Mitochondria: A therapeutic target in neurodegeneration

Moreira, P. I., Zhu, X., Wang, X., Lee, H., Nunomura, A., Petersen, R. B., Perry, G. L., & Smith, M. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.007 · Cited by 286 · see citing works

Base Excision Repair and Lesion-Dependent Subpathways for Repair of Oxidative DNA Damage

Svilar, D., Goellner, E. M., Almeida, K. H., & Sobol, R. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3466 · Cited by 254 · see citing works

Oxidative stress in the pathogenesis of psoriasis

Zhou, Q., Mrowietz, U., & Rostami‐Yazdi, M. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.06.033 · Cited by 274 · see citing works

Combination therapy with Coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson’s and Huntington’s Diseases

Yang, L., Calingasan, N. Y., Wille, E. J., Cormier, K., Smith, K., Ferrante, R. J., & Beal, M. F. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06074.x · Cited by 232 · see citing works

Progress in Parkinson's disease—Where do we stand?

Toulouse, A., & Sullivan, A. M. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.05.003 · Cited by 194 · see citing works

Coenzyme Q10 effects in neurodegenerative disease

Henchcliffe, C. (2009) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s5212 · Cited by 188 · see citing works

Coenzyme Q10 Inhibits Glutamate Excitotoxicity and Oxidative Stress–Mediated Mitochondrial Alteration in a Mouse Model of Glaucoma

Lee, D.-W., Shim, M. S., Keun-young Kim, A., Noh, Y. H., Kim, H., Kim, S. Y., Weinreb, R. N., & Ju, W. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12564 · Cited by 182 · see citing works

Mitochondrial dysfunction in bipolar disorder: Evidence, pathophysiology and translational implications

Scaini, G., Rezin, G. T., Carvalho, A. F., STRECK, E. L., Berk, M., & Quevedo, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.040 · Cited by 184 · see citing works

A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay

Boyd, W. A., McBride, S. J., Rice, J. R., Snyder, D. W., & Freedman, J. H. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.02.014 · Cited by 176 · see citing works

Coenzyme Q10 Decreases Amyloid Pathology and Improves Behavior in a Transgenic Mouse Model of Alzheimer's Disease

Dumont, M., Kipiani, K., Yu, F., Wille, E. J., Katz, M., Calingasan, N. Y., Gouras, G. K., Lin, M. T. S., & Beal, M. F. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110209 · Cited by 161 · see citing works

Pancratistatin: A natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis

McLachlan, A., Kekre, N. K., McNulty, J., & Pandey, S. (2005) · APOPTOSIS · doi:10.1007/s10495-005-1896-x · Cited by 156 · see citing works

Mitochondrial Oxidative Damage in Aging and Alzheimer′s Disease: Implications for Mitochondrially Targeted Antioxidant Therapeutics

Reddy, P. H. (2006) · BioMed Research International · doi:10.1155/jbb/2006/31372 · Cited by 153 · see citing works

Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes

Noh, Y. H., Kim, K., Shim, M. S., Choi, S.-H., Choi, S., Ellisman, M. H., Weinreb, R. N., Perkins, G. A., & Ju, W.-K. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.341 · Cited by 146 · see citing works

Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation.

Ramachandiran, S., Hansen, J. M., Jones, D. P., Richardson, J., & Miller, G. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfl125 · Cited by 143 · see citing works

Neuroprotection and antioxidants

Lalkovičová, M., & Danielisová, V. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.184447 · Cited by 132 · see citing works

Use of conventional and -omics based methods for health claims of dietary antioxidants: a critical overview

Knasmüller, S., Nersesyan, A., Mišík, M., Gerner, C., Mikulits, W., Ehrlich, V. A., Hoelzl, C., Szakmary, A., & Wagner, K. (2008) · British Journal of Nutrition · doi:10.1017/s0007114508965752 · Cited by 102 · see citing works

Oxidative Toxicity in Neurodegenerative Diseases: Role of Mitochondrial Dysfunction and Therapeutic Strategies

Facecchia, K., Fochesato, L.-A., Ray, S. D., Stohs, S. J., & Pandey, S. (2011) · Journal of Toxicology · doi:10.1155/2011/683728 · Cited by 118 · see citing works

Paraquat induces oxidative stress, neuronal loss in substantia nigra region and Parkinsonism in adult rats: Neuroprotection and amelioration of symptoms by water-soluble formulation of Coenzyme Q10

Somayajulu‐Nitu, M., Sandhu, J. K., Cohen, J. S., Sikorska, M., Sridhar, T., Matei, A., Borowy‐Borowski, H., & Pandey, S. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-88 · Cited by 117 · see citing works

The toxic influence of paraquat on hippocampus of mice: Involvement of oxidative stress

Chen, Q., Niu, Y., Zhang, R., Guo, H., Gao, Y., Li, Y., & Liu, R. (2010) · NeuroToxicology · doi:10.1016/j.neuro.2010.02.006 · Cited by 116 · see citing works

Neuroprotection in Glaucoma: Drug‐Based Approaches

Cheung, W., Guo, L., & Cordeiro, M. F. (2008) · Optometry and Vision Science · doi:10.1097/opx.0b013e31817841e5 · Cited by 114 · see citing works

Design and Evaluation of Multifunctional Nanocarriers for Selective Delivery of Coenzyme Q10 to Mitochondria

Sharma, A., Soliman, G. M., Al‐Hajaj, N., Sharma, R. B., Maysinger, D., & Kakkar, A. K. (2011) · Biomacromolecules · doi:10.1021/bm201538j · Cited by 110 · see citing works

Topical Coenzyme Q10 demonstrates mitochondrial-mediated neuroprotection in a rodent model of ocular hypertension

Davis, B. M., Tian, K., Pahlitzsch, M., Brenton, J., Ravindran, N., Butt, G. F., Malaguarnera, G., Normando, E. M., Guo, L., & Cordeiro, M. F. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.05.010 · Cited by 106 · see citing works

Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson’s Disease

Huang, M., Bargues-Carot, A., Riaz, Z., Wickham, H., Zenitsky, G. D., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810808 · Cited by 111 · see citing works

Parkinson’s disease: oxidative stress and therapeutic approaches

Surendran, S., & Rajasankar, S. (2010) · Neurological Sciences · doi:10.1007/s10072-010-0245-1 · Cited by 106 · see citing works

Cytotoxicity of paraquat in microglial cells: Involvement of PKCδ- and ERK1/2-dependent NADPH oxidase

Miller, R. L., Sun, G. Y., & Sun, A. Y. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.046 · Cited by 99 · see citing works

Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-β1 expression

Choi, H., Pokharel, Y. R., Lim, S., Han, H.-K., Ryu, C. S., Kim, S. K., Kwak, M. K., & Kang, K. W. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.07.030 · Cited by 98 · see citing works

A link between the accumulation of DNA damage and loss of multi‐potency of human mesenchymal stromal cells

Alves, H., Muñoz-Nájar, U., de Wit, J., Renard, A. J. S., Hoeijmakers, J. H. J., Sedivy, J. M., van Blitterswijk, C., & de Boer, J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00931.x · Cited by 97 · see citing works

Neuroprotection in glaucoma

Doozandeh, A., & Yazdani, S. (2016) · Journal of Ophthalmic and Vision Research · doi:10.4103/2008-322x.183923 · Cited by 96 · see citing works

Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL)

Fetoni, A. R., Piacentini, R., Fiorita, A., Paludetti, G., & Troiani, D. (2008) · Brain Research · doi:10.1016/j.brainres.2008.12.027 · Cited by 96 · see citing works

CoQ10 therapy attenuates amyloid β-peptide toxicity in brain mitochondria isolated from aged diabetic rats

Moreira, P. I., Santos, M. S., Sena, C. M., NUNES, E., Seiça, R. M. F., & Oliveira, C. R. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.07.012 · Cited by 93 · see citing works

Autophagy regulates chlorpyrifos-induced apoptosis in SH-SY5Y cells

Park, J. H., Lee, J. E., Shin, I. C., & Koh, H. C. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.01.013 · Cited by 92 · see citing works

Inhibitory effects of paraquat on photosynthesis and the response to oxidative stress in Chlorella vulgaris

Qian, H., Chen, W., Sun, L., Jin, Y., Liu, W., & Fu, Z. (2009) · Ecotoxicology · doi:10.1007/s10646-009-0311-8 · Cited by 92 · see citing works

Chemically Diverse Toxicants Converge on Fyn and c-Cbl to Disrupt Precursor Cell Function

Li, Z., Dong, T., Pröschel, C., & Noble, M. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050035 · Cited by 90 · see citing works

Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury

Lee, D.-W., Keun-young Kim, A., Shim, M. S., Kim, S. Y., Ellisman, M. H., Weinreb, R. N., & Ju, W. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0956-x · Cited by 89 · see citing works

Reactive oxygen species in in vitro pesticide-induced neuronal cell (SH-SY5Y) cytotoxicity: Role of NFκB and caspase-3

Jia, Z., & Misra, H. P. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.10.047 · Cited by 85 · see citing works

A Water Soluble CoQ10 Formulation Improves Intracellular Distribution and Promotes Mitochondrial Respiration in Cultured Cells

Bergamini, C., Moruzzi, N., Sblendido, A., Lenaz, G., & Fato, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033712 · Cited by 84 · see citing works

Degradation of paraquat herbicide by electrochemical advanced oxidation methods

Dhaouadi, A., & Adhoum, N. (2009) · Journal of Electroanalytical Chemistry · doi:10.1016/j.jelechem.2009.09.027 · Cited by 83 · see citing works

Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration

Kachroo, A., Irizarry, M. C., & Schwarzschild, M. A. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.02.007 · Cited by 82 · see citing works

Mitochondrial Dysfunction in Parkinson's Disease: Pathogenesis and Neuroprotection

Mounsey, R. B., & Teismann, P. (2010) · Parkinson s Disease · doi:10.4061/2011/617472 · Cited by 82 · see citing works

Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies

Mongirdienė, A., Skrodenis, L., Varoneckaitė, L., Mierkytė, G., & Gerulis, J. (2022) · Biomedicines · doi:10.3390/biomedicines10030602 · Cited by 83 · see citing works

Understanding coenzyme Q

Wang, Y., Lilienfeldt, N., & Hekimi, S. (2024) · Physiological Reviews · doi:10.1152/physrev.00040.2023 · Cited by 83 · see citing works

Reactive oxygen species and mitogen-activated protein kinase induce apoptotic death of SH-SY5Y cells in response to fipronil

Ki, Y.-W., Lee, J. E., Park, J. H., Shin, I. C., & Koh, H. C. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.02.022 · Cited by 79 · see citing works

Neuroprotective effects of (−)‐epigallocatechin‐3‐gallate (EGCG) on paraquat‐induced apoptosis in PC12 cells

Hou, R., Chen, J., Chen, H., Kang, X., Li, M., & Wang, B. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.08.007 · Cited by 79 · see citing works

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Xu, C., Liu, Z., & Xiao, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212403 · Cited by 78 · see citing works

Coenzyme Q10 Inhibits the Aging of Mesenchymal Stem Cells Induced by D-Galactose through Akt/MTOR Signaling

Zhang, D., Yan, B., Yu, S., Zhang, C., Wang, B., Wang, Y., Wang, J., Yuan, Z., Zhang, L., & Pan, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/867293 · Cited by 75 · see citing works

Method for measurement of the quaternary amine compounds paraquat and diquat in human urine using high-performance liquid chromatography–tandem mass spectrometry

Whitehead, R. D., Montesano, M. A., Jayatilaka, N. K., Buckley, B., Winnik, B., Needham, L. L., & Barr, D. B. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.09.029 · Cited by 75 · see citing works

Parkinson Disease and Exercise

Earhart, G. M., & Falvo, M. J. (2013) · Comprehensive physiology · doi:10.1002/cphy.c100047 · Cited by 77 · see citing works

Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration

Baskoylu, S., Yersak, J. M., O’Hern, P., Grosser, S., Simon, J., Kim, S. Y., Schuch, K. N., Dimitriadi, M., Yanagi, K. S., Lins, J., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007682 · Cited by 71 · see citing works

Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice

Fu, Z., Wang, Z., Liu, C., Gong, Y. Q., Cakir, B., Liegl, R. G.-H., Sun, Y., Meng, S. S., Burnim, S. B., Arellano, I. A., et al. (2018) · Diabetes · doi:10.2337/db17-0830 · Cited by 72 · see citing works

Nanomicellar formulation of coenzyme Q10 (Ubisol-Q10) effectively blocks ongoing neurodegeneration in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model: potential use as an adjuvant treatment in Parkinson's disease

Sikorska, M., Lanthier, P., Miller, H., Beyers, M., Sodja, C., Zurakowski, B., Gangaraju, S., Pandey, S., & Sandhu, J. K. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.032 · Cited by 70 · see citing works

Coculture of Primary Motor Neurons and Schwann Cells as a Model for In Vitro Myelination

Hyung, S., Lee, B. Y., Park, J., Kim, J., Hur, E., & Suh, J. F. (2015) · Scientific Reports · doi:10.1038/srep15122 · Cited by 68 · see citing works

Paraquat Increases Cyanide-insensitive Respiration in Murine Lung Epithelial Cells by Activating an NAD(P)H:Paraquat Oxidoreductase

Gray, J. P., Heck, D. E., Mishin, V. M., Smith, P. J., Hong, J., Thiruchelvam, M. J., Cory‐Slechta, D. A., Laskin, D. L., & Laskin, J. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611817200 · Cited by 68 · see citing works

Water-soluble formulation of Coenzyme Q10 inhibits Bax-induced destabilization of mitochondria in mammalian cells

Naderi, J., Somayajulu‐Nitu, M., Mukerji, A., Sharda, P. R., Sikorska, M., Borowy‐Borowski, H., Antonsson, B. E., & Pandey, S. (2006) · APOPTOSIS · doi:10.1007/s10495-006-8417-4 · Cited by 66 · see citing works

Protective effects of Ginkgo biloba extract on paraquat-induced apoptosis of PC12 cells

Kang, X., Chen, J., Xu, Z., Li, H., & Wang, B. (2007) · Toxicology in Vitro · doi:10.1016/j.tiv.2007.02.004 · Cited by 66 · see citing works

Efficient visible light-induced photocatalytic removal of paraquat using N-doped TiO2@SiO2@Fe3O4 nanocomposite

Pourzad, A., Sobhi, H. R., Behbahani, M., Esrafili, A., Kalantary, R. R., & Kermani, M. (2019) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2019.112167 · Cited by 65 · see citing works

HMGB1-TLR4-IL23-IL17A axis promotes paraquat-induced acute lung injury by mediating neutrophil infiltration in mice

Yan, B., Chen, F., Xu, L., Xing, J., & Wang, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-00721-8 · Cited by 65 · see citing works

Neuroprotective effects of coenzyme Q10 on neurological diseases: a review article

Bagheri, S., Haddadi, R., Saki, S., Kourosh‐Arami, M., Rashno, M., Mojaver, A., & Komaki‬, A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1188839 · Cited by 70 · see citing works

Assessment of neuroprotection in the retina with DARC

Guo, L., & Cordeiro, M. F. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)01130-8 · Cited by 64 · see citing works

Quantitative determination of paraquat in meconium by sodium borohydride-nickel chloride chemical reduction and gas chromatography/mass spectrometry (GC/MS)

Posecion, N. C., Ostrea, E. M., & Bielawski, D. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.11.002 · Cited by 64 · see citing works

Metformin reduces angiotensin-mediated intracellular production of reactive oxygen species in endothelial cells through the inhibition of protein kinase C.

Mahrouf, M., Ouslimani, N., Peynet, J., Djelidi, R., Couturier, M., Thérond, P., Legrand, A., & Beaudeux, J.-L. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.027 · Cited by 67 · see citing works

Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival

Toyoda, Y., Erkut, C., Pan-Montojo, F. J., Boland, S., Stewart, M. P., Müller, D. J., Wurst, W., Hyman, A. A., & Kurzchalia, T. V. (2014) · Biology Open · doi:10.1242/bio.20149399 · Cited by 59 · see citing works

Coenzyme Q10 effects in neurological diseases

Rauchová, H. (2021) · Physiological Research · doi:10.33549/physiolres.934712 · Cited by 63 · see citing works

Paraquat induces apoptosis in human lymphocytes: Protective and rescue effects of glucose, cannabinoids and insulin-like growth factor-1

Jiménez-Del-Río, M., & Velez‐Pardo, C. (2008) · Growth Factors · doi:10.1080/08977190801984205 · Cited by 56 · see citing works

Tanshinone I Induces Mitochondrial Protection through an Nrf2-Dependent Mechanism in Paraquat-TreatedHuman Neuroblastoma SH-SY5Y Cells

de Oliveira, M. R., Schuck, P. F., & Bosco, S. M. D. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0009-x · Cited by 51 · see citing works

Cyclooxygenase‐2 deficiency modifies the neurochemical effects, motor impairment and co‐morbid anxiety provoked by paraquat administration in mice

Litteljohn, D., Mangano, E. N., & Hayley, S. P. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06371.x · Cited by 51 · see citing works

Evaluation of the Neurotoxic/Neuroprotective Role of Organoselenides Using Differentiated Human Neuroblastoma SH-SY5Y Cell Line Challenged with 6-Hydroxydopamine

Lopes, F. M., Londero, G. F., de Medeiros, L. M., da Motta, L. L., Behr, G. A., de Oliveira, V. A., Ibrahim, M., Moreira, J. C. F., Porciúncula, L. O., da Rocha, J. B. T., et al. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9311-1 · Cited by 50 · see citing works

Airborne toluene exposure causes germline apoptosis and neuronal damage that promotes neurobehavioural changes in Caenorhabditis elegans

Soares, M. V., Charão, M. F., Jacques, M. T., dos Santos, A. L. A., Luchese, C., Pinton, S., & Ávila, D. S. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113406 · Cited by 49 · see citing works

Biotin, coenzyme Q10, and their combination ameliorate aluminium chloride‐induced Alzheimer's disease via attenuating neuroinflammation and improving brain insulin signaling

Attia, H., Albuhayri, S., Alaraidh, S., Alotaibi, A., Yacoub, H. I., Mohamad, R. A., & Alamin, M. A. (2020) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22519 · Cited by 47 · see citing works

Impairment of the mitochondrial respiratory enzyme activity triggers sequential activation of apoptosis‐inducing factor‐dependent and caspase‐dependent signaling pathways to induce apoptosis after spinal cord injury

Wu, K. L. H., Hsu, C., & Chan, J. Y. H. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04445.x · Cited by 47 · see citing works

Sodium salicylate prevents paraquat-induced apoptosis in the rat lung

Dinis‐Oliveira, R. J., Sousa, C., Remião, F., Duarte, J. A., Ferreira, R. M., Navarro, A. S., Bastos, M. D. L., & Carvalho, F. D. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.014 · Cited by 47 · see citing works

Management of the aging risk factor for Parkinson's disease

Phillipson, O. T. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.10.073 · Cited by 46 · see citing works

Neuroprotective effects of coenzyme Q10 on paraquat-induced Parkinson’s disease in experimental animals

Attia, H. N., & Maklad, Y. A. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000342 · Cited by 46 · see citing works

Inflammasomes: An Emerging Mechanism Translating Environmental Toxicant Exposure Into Neuroinflammation in Parkinson’s Disease

Anderson, F. L., Coffey, M., Berwin, B. L., & Havrda, M. C. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy219 · Cited by 47 · see citing works

Mitochondria-mediated damage to dopaminergic neurons in Parkinson's disease (Review)

Liu, X., Wang, Y., Yu, X., Li, D., & Li, G. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3255 · Cited by 45 · see citing works

Supplementation with Qter® and Creatine improves functional performance in COPD patients on long term oxygen therapy

Benedetto, F. D., Pastorelli, R., Ferrario, M., de Blasio, F., Marinari, S., Brunelli, L., Wouters, E. F. �., Polverino, F., & Celli, B. R. (2018) · Respiratory Medicine · doi:10.1016/j.rmed.2018.08.002 · Cited by 44 · see citing works

Targeting Parkinson’s - Tyrosine Hydroxylase and Oxidative Stress as Points of Interventions

Khan, M. S., Tabrez, S. S. M., Priyadarshini, M., Priyamvada, S., & Khan, M. M. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712800792848 · Cited by 43 · see citing works

Targeting Adenosine Signaling in Parkinson's Disease: From Pharmacological to Non-pharmacological Approaches

Nazario, L. R., da Silva, R. S., & Bonan, C. D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00658 · Cited by 43 · see citing works

Resveratrol Protects from Toxin-Induced Parkinsonism: Plethora of Proofs Hitherto Petty Translational Value

Rasheed, M. S. U., Tripathi, M. K., Mishra, A. K., Shukla, S., & Singh, M. P. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9124-3 · Cited by 42 · see citing works

m TOR inhibition by rapamycin protects against deltamethrin‐induced apoptosis in PC 12 Cells

Park, Y. S., Park, J. H., Ko, J., Shin, I. C., & Koh, H. C. (2015) · Environmental Toxicology · doi:10.1002/tox.22216 · Cited by 42 · see citing works

Environmental contaminants in pathogenesis of breast cancer.

Mukherjee, S., Koner, B. C., Ray, S., & Ray, A. (2006) · PubMed · Cited by 42 · see citing works

Oral administration of Coenzyme Q10 protects mice against oxidative stress and neuro-inflammation during experimental cerebral malaria

Nyariki, J. N., Ochola, L. B., Jillani, N., Nyamweya, N. O., Amwayi, P. W., Yole, D., Azonvide, L., & Isaac, A. O. (2019) · Parasitology International · doi:10.1016/j.parint.2019.04.010 · Cited by 42 · see citing works

Ferroptosis Regulation by Nutrient Signalling

Qi, Y., Zhang, X., Wu, Z., Tian, M., Chen, F., Guan, W., & Zhang, S. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000226 · Cited by 41 · see citing works

Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy

Varesi, A., Campagnoli, L. I. M., Carrara, A., Pola, I., Floris, E., Ricevuti, G., Chirumbolo, S., & Pascale, A. (2023) · Antioxidants · doi:10.3390/antiox12010180 · Cited by 45 · see citing works

A multicommuted flow system with solenoid micro-pumps for paraquat determination in natural waters

Infante, C. M. C., Morales‐Rubio, Á., de la Guárdia, M., & Rocha, F. R. P. (2008) · Talanta · doi:10.1016/j.talanta.2008.01.050 · Cited by 40 · see citing works

Inhibition of Stress Induced Premature Senescence in Presenilin-1 Mutated Cells with Water Soluble Coenzyme Q10

Ma, D., Stokes, K., Mahngar, K., Domazet-Damjanov, D., Sikorska, M., & Pandey, S. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.07.004 · Cited by 39 · see citing works

Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration

Qi, Y., Liu, H., Daniels, M. P., Zhang, G., & Xu, H. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.94 · Cited by 37 · see citing works

Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis

Khalilian, B., Madadi, S., Fattahi, N., & Abouhamzeh, B. (2020) · Journal of Molecular Histology · doi:10.1007/s10735-020-09929-x · Cited by 39 · see citing works

Paraquat-Induced Movement Disorder in Relation to Oxidative Stress-Mediated Neurodegeneration in the Brain of Drosophila melanogaster

Niveditha, S., Ramesh, S. R., & Shivanandappa, T. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2373-y · Cited by 37 · see citing works

Chronic unpredictable stress influenced the behavioral but not the neurodegenerative impact of paraquat

Rudyk, C., Dwyer, Z., McNeill, J., Salmaso, N., Farmer, K., Prowse, N. A., & Hayley, S. P. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100179 · Cited by 37 · see citing works

Paraquat induces oxidative stress and neuronal cell death: Neuro-protection by water-soluble coenzyme Q 10.: Toxicol.Appl.Pharmacol.

Mccarthy, S., Somayajulu, M., Walker, M. S., Borowy‐Borowski, H., & Pandey, S. (2004) · NPARC

Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson’s disease

Muthukumaran, K., Leahy, S., Harrison, K., Sikorska, M., Sandhu, J. K., Cohen, J. S., Keshan, C., Lopatin, D., Miller, H., Borowy‐Borowski, H., et al. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-21 · Cited by 68 · see citing works

Paraquat induces oxidative stress, neuronal loss in substantia nigra region and Parkinsonism in adult rats: Neuroprotection and amelioration of symptoms by water-soluble formulation of Coenzyme Q10

Somayajulu‐Nitu, M., Sandhu, J. K., Cohen, J. S., Sikorska, M., Sridhar, T., Matei, A., Borowy‐Borowski, H., & Pandey, S. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-88 · Cited by 117 · see citing works

Paraquat is a Model Environmental Neurotoxin for Studying Parkinson’s Disease

Sun, A. Y., & Li, X. (2000) · Springer eBooks · doi:10.1007/978-1-4615-1269-1_24 · Cited by 1 · see citing works

Mitochondrial susceptibility in a model of paraquat neurotoxicity

Czerniczyniec, A., Lores‐Arnaiz, S., & Bustamante, J. (2013) · Free Radical Research · doi:10.3109/10715762.2013.806797 · Cited by 21 · see citing works