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The Protein-Folding Problem, 50 Years On

Dill, Ken A., MacCallum, Justin L.·2012·Science

DOI 10.1126/science.1219021

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Abstract

Protein Folding: Past and Future: Fifty years ago the Nobel Prize in chemistry was awarded to Max Perutz and John Kendrew for determining the structure of globular proteins. Since first viewing their structure of myoglobin, scientists have sought to understand protein folding. Dill and MacCallum (p. 1042 ) review the progress that has been made on three central questions: What is the code that relates sequence to structure? How do proteins fold so fast? Can protein structure be computationally predicted? While we have come some way toward answering these questions, new questions have been gene rated. It is no longer useful to talk about “solving the protein-folding problem”—protein folding has grown into a field of research where the next 50 years promise to be as exciting as the last.

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Authors: Dill, K. A., & MacCallum, J. L.
Affiliations: Stony Brook University (US)
Corresponding author: Dill, Ken A.
ORCID: Dill, Ken A.
MacCallum, Justin L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2012-11-23
Volume: 338
Issue: 6110
Pages: 1042-1046
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1219021
OpenAlex: W2014050554
Cited by: 1,699
References: 72
Citations by year: 2026: 140 · 2025: 132 · 2024: 117 · 2023: 148 · 2022: 114 · 2021: 137 · 2020: 123 · 2019: 144 · 2018: 111 · 2017: 123 · 2016: 121 · 2015: 119 · 2014: 94 · 2013: 73 · 2012: 1
FWCI: 8.37
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM34993, R01GM034993)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Keywords: protein folding, folding kinetics, folding funnel, energy landscape, thermal fluctuations, protein structure prediction, Protein Data Bank
MeSH terms: Amino Acid Sequence, Computer Simulation, Pharmaceutical Preparations, Models, Chemical, Protein Conformation, Proteins, Protein Folding, Caspase 9

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The Protein-Folding Problem, 50 Years On

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