BDNF Is a Negative Modulator of Morphine Action

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860

NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory

Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647

The debate over dopamine’s role in reward: the case for incentive salience

Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347

Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions

Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129

Neurotrophins and Neuronal Plasticity

Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927

Is there a common molecular pathway for addiction?

Nestler, E. J. (2005) · Nature Neuroscience · doi:10.1038/nn1578 · Cited by 1,388

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266

Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons

Saal, D., Dong, Y., Bonci, A., & Malenka, R. C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00021-7 · Cited by 1,147

Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission

Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106

Neuroplasticity transcript profile of the ventral striatum in the extinction of opioid-induced conditioned place preference

Martínez-Rivera, F. J., Martinez, N. A., Martínez, M., Ayala-Pagán, R. N., Silva, W. I., & Barreto-Estrada, J. L. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107031 · Cited by 13

Energy sensors in drug addiction: A potential therapeutic target

López-Gambero, A. J., de Fonseca, F. R., & Suárez, J. (2020) · Addiction Biology · doi:10.1111/adb.12936 · Cited by 14

Pavlovian conditioning and cross-sensitization studies raise challenges to the hypothesis that overeating is an addictive behavior

Harb, M. R., & Almeida, O. F. X. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.28 · Cited by 13

Microinjection of the BDNF receptor antagonist ANA-12 into the nucleus accumbens and medial-prefrontal cortex attenuates morphine-induced reward memory, and alterations of BDNF levels and apoptotic cells in rats

Jorjani, H., Joneidi, M., Vafaei, A. A., Rashidy‐Pour, A., Sameni, H., Bandegi, A. R., Yousefi, B., & Miladi‐Gorji, H. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173111 · Cited by 12

Effects of Morphine and Maternal Care on Behaviors and Protein Expression of Male Offspring

Akbarabadi, A., Sadat‐Shirazi, M., Kabbaj, M., Zadeh‐Tehrani, S. N., Khalifeh, S., Pirri, F., & Zarrindast, M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.04.011 · Cited by 13

Molecular, Cellular, and Circuit Basis of Depression Susceptibility and Resilience

Han, M., Russo, S. J., & Nestler, E. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00012-3 · Cited by 13

The Inflammation/NF-κB and BDNF/TrkB/CREB Pathways in the Cerebellum Are Implicated in the Changes in Spatial Working Memory After Both Morphine Dependence and Withdrawal in Rat

Ahmadi, S., Majidi, M., Koraei, M., & Vasef, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03993-0 · Cited by 12

The potential rewarding and reinforcing effects of the substituted benzofurans 2-EAPB and 5-EAPB in rodents

Sayson, L. V., Custodio, R. J. P., Ortiz, D. M., Lee, H. J., Kim, M., Jeong, Y., Lee, Y. S., Kim, H. J., & Cheong, J. H. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173527 · Cited by 12

Alterations in neurotransmitter levels and transcription factor expression following intranasal buprenorphine administration

Xhakaza, S. P., Khoza, L. J., Haripershad, A. M., Ghazi, T., Dhani, S., Mutsimhu, C., Molopa, M. J., Madurai, N. P., Madurai, L., Singh, S. D., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111515 · Cited by 12

Opium Effect in Pregnancy on the Dynamics of Maternal Behavior: Testing a Neurochemical Model

Rezaei, S., Bakhshani, N., Fanaei, H., & Trofimova, I. N. (2021) · Neuropsychobiology · doi:10.1159/000512698 · Cited by 12

The Ameliorative Effects of Isorhynchophylline on Morphine Dependence Are Mediated Through the Microbiota-Gut-Brain Axis

Chen, Z., Zhijie, C., Yuting, Z., Li, C., Shilin, X., Qichun, Z., Ou, J., Li, J., Chaohua, L., & Zhi-xian, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.526923 · Cited by 12

Melatonin Blocks Morphine-Induced Place Preference: Involvement of GLT-1, NF-κB, BDNF, and CREB in the Nucleus Accumbens

Alghamdi, B. S. A., & Alshehri, F. S. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.762297 · Cited by 12

JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference

Babigian, C. J., Wiedner, H. J., Wahlestedt, C., & Sartor, G. C. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113644 · Cited by 11

Effects of BDNF receptor antagonist on the severity of physical and psychological dependence, morphine-induced locomotor sensitization and the ventral tegmental area-nucleus accumbens BDNF levels in morphine- dependent and withdrawn rats

Khalil-Khalili, M., Rashidy‐Pour, A., Bandegi, A. R., Yousefi, B., Jorjani, H., & Miladi‐Gorji, H. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.12.061 · Cited by 12

Epigenetics and Drug Abuse

Bastle, R. M., & Neisewander, J. L. (2016) · InTech eBooks · doi:10.5772/63952 · Cited by 11

Increased BDNF-TrkB signaling in the nucleus accumbens plays a role in the risk for psychosis after cannabis exposure during adolescence

Dong, C., Tian, Z. R., Zhang, K., Chang, L., Qu, Y., Pu, Y., Ren, Q., Fujita, Y., Ohgi, Y., Futamura, T., et al. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.01.002 · Cited by 10

Hippocampal and amygdalar increased BDNF expression in the extinction of opioid-induced place preference

Lloret-Torres, M. E., Ayala-Pagán, R. N., Martínez-Rivera, F. J., Bonilla-Rullán, P., & Barreto-Estrada, J. L. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.10.007 · Cited by 9

Brain-derived neurotrophic factor involved epigenetic repression of UGT2B7 in colorectal carcinoma: A mechanism to alter morphine glucuronidation in tumor

Yang, Z.-Z., Li, L., Xu, M.-C., Ju, H.-X., Hao, M., Gu, J.-K., Wang, Z.-J. J., Jiang, H.-D., Yu, L.-S., & Zeng, S. (2017) · Oncotarget · doi:10.18632/oncotarget.16251 · Cited by 10

Differential Roles of Accumbal GSK3β in Cocaine versus Morphine-Induced Place Preference, U50,488H-Induced Place Aversion, and Object Memory

Shi, X., Barr, J. L., von Weltin, E., Wolsh, C. C., & Unterwald, E. M. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.259283 · Cited by 9

Genomics testing and personalized medicine in the preoperative setting: Can it change outcomes in postoperative pain management?

Chaturvedi, R., Alexander, B. S., A’Court, A. M., Waterman, R. S., Burton, B. N., Urman, R. D., & Gabriel, R. A. (2020) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2020.05.008 · Cited by 9

Mu-opioid signaling modulates biphasic expression of TrkB and IκBα genes and neurite outgrowth in differentiating and differentiated human neuroblastoma cells

Wen, A., Guo, A., & Chen, Y. L. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.02.031 · Cited by 8

Molecular architects of memory: BDNF/TrkB signaling and trafficking in neuronal plasticity and memory

Teng, S.-W., Chen, X.-L., & Chen, Z.-Y. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03552-0 · Cited by 9

Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen

Valderrama‐Carvajal, A., Irizar, H., Gago, B., Jiménez‐Urbieta, H., Fuxé, K., Rodríguez‐Oroz, M., Otaegui, D., & Rivera, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-25604-4 · Cited by 8

Distinct regulation pattern of Egr-1, BDNF and Arc during morphine-withdrawal conditioned place aversion paradigm: Role of glucocorticoids

García‐Pérez, D., Ferenczi, S., Kovács, K., & Milanés, M. V. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.026 · Cited by 9

Effects of brain-derived neurotrophic factor and adeno-associated viral vector on morphine-induced condition through target concentration changes in the ventral tegmental area and nucleus accumbens

Deng, L., Chu, Z., Liu, P., Li, B., Lei, G., Li, S., Ma, Y., & Dang, Y. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114385 · Cited by 8

A role of anterior cingulate cortex in the emergence of worker–parasite relationship

Ahn, S., Kang, Y., Lee, J. W., Jeong, S. J., Lee, Y. J., Lee, S., Kim, J., Kim, J. J., Kim, J. J., & Jung, M. W. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111145118 · Cited by 7

Genetic Variants Linked to Opioid Addiction: A Genome-Wide Association Study

Panday, S. K., Lyman, R. A., Shankar, V., & Alexov, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312516 · Cited by 7

A neuronal population code for resemblance between drug and nondrug reward outcomes in the orbitofrontal cortex

Guillem, K., & Ahmed, S. H. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1809-8 · Cited by 7

Interruption of Continuous Opioid Exposure Exacerbates Drug-Evoked Adaptations in the Mesolimbic Dopamine SystemPreprint

Lefevre, E. M., Pisansky, M. T., Toddes, C., Baruffaldi, F., Pravetoni, M., Tian, L., Kono, T. J. Y., & Rothwell, P. E. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/646356 · Cited by 7

BDNF receptor antagonism during the induction of morphine dependence exacerbates the severity of physical dependence and ameliorates psychological dependence in rats

Rezamohammadi, F., Rahmani, M., Ghanbari, A., Khaleghian, A., & Miladi‐Gorji, H. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135332 · Cited by 6

MicroRNA may regulate the content of the brain-derived neurotrophic factor in the frontal cortex of rats after spontaneous morphine withdrawal

Peregud, D., Panchenko, L. F., & Gulyaeva, N. V. (2016) · Neurochemical Journal · doi:10.1134/s1819712416040085 · Cited by 6

BDNF ValMet polymorphism tunes frontolimbic circuitry during affective contextual learning

Jabbi, M., Cropp, B., Nash, T. A., Kohn, P. D., Kippenhan, J. S., Masdeu, J. C., Mattay, R., Kolachana, B. S., & Berman, K. F. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.08.080 · Cited by 5

Optogenetics: illuminating the neural bases of rodent behavior

Lobo, M. K., Francis, C., & Chaudhury, D. (2014) · Open Access Animal Physiology · doi:10.2147/oaap.s42339 · Cited by 6

Impairment of cost-benefit decision making in morphine-dependent rats is partly mediated via the alteration of BDNF and p-CREB levels in the nucleus accumbens

Fatahi, Z., Zeinaddini-Meymand, A., Karimi, S., Khodagholi, F., & Haghparast, A. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172952 · Cited by 5

Intermediation of perceived stress between early trauma and plasma M/P ratio levels in obsessive-compulsive disorder patients

Li, P., Cheng, J., Gu, Q., Wang, P., Lin, Z., Fan, Q., Chen, J., & Wang, Z. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.02.046 · Cited by 6

The BDNF Protein and its Cognate mRNAs in the Rat Spinal Cord during Amylin-induced Reversal of Morphine Tolerance

Khoshdel, Z., Jirandeh, S. A., Takhshid, M. A., Mashayekhi, F. J., Shojaei, S., & Owji, A. A. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.034 · Cited by 6

Chronic Pain, Impulsivity, and Risk for Opioid Misuse

Ramesh, D., & Evans, H. (2018) · Topics in Pain Management · doi:10.1097/01.tpm.0000541408.17994.3f · Cited by 5

LF-DBS of the ventral striatum shortens persistence for morphine place preference and modulates BDNF expression in the hippocampus

Lloret-Torres, M. E., & Barreto-Estrada, J. L. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115300 · Cited by 4

Morphine produces better thermal analgesia in young Huntington mice and are associated with less neuroinflammation in spinal cord

Liu, Y., Lin, Y.-C., Hsiao, H., Wang, J. C.-F., & Liu, Y. (2020) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000448 · Cited by 4

Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols

Horáček, J., Janda, R., Görnerová, N., Jajcay, L., & Andrashko, V. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137095 · Cited by 4

Neuromodulation for Addiction

Kuhn, J., Möller, M., Lenartz, D., Bührle, C., & Visser-Vandewalle, V. E. R. M. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1408-1_17 · Cited by 4

The Use of Herpes Simplex Virus in Ex Vivo Slice Culture

Friedman, A. K., & Han, M. (2015) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0436s72 · Cited by 4

BDNF-AAV has protective effects on morphine-induced conditioned place preference through BDNF, TrkB, and CREB concentration changes in the VTA and NAc

Deng, L., Chu, Z., Li, B., Liu, P., Lei, G., Yang, L., Zhang, L., Li, S., Wang, Y., & Dang, Y. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136701 · Cited by 6

Baclofen prevents morphine rewarding effects and associated biochemical alterations in male and female mice

Pedrón, V. T., Canero, E. M., Varani, A. P., Aon, A. J., Maldonado, R. J., & Balerio, G. N. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176768 · Cited by 4

Identification of a Novel Population of Neuromedin S Expressing Neurons in the Ventral Tegmental Area That Promote Morphine-Elicited Behavior

Quiles, C. R., Simmons, S. C., Dodson, O., Alday, M., Fontánez, N. C., Caico, S., Garrison, A., Shafieichaharberoud, F., Huang, X., Hu, Q., et al. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1662-24.2025 · Cited by 3

Chronic morphine intoxication reduces binding of HuD to BDNF long 3′-UTR, while morphine withdrawal stimulates BDNF expression in the frontal cortex of male Wistar rats

Peregud, D., Панченко, Л. Ф., & Gulyaeva, N. V. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1809395 · Cited by 3

Elevation of DNA Methylation in the Promoter Regions of the Brain-Derived Neurotrophic Factor Gene is Associated with Heroin Addiction

Xiao, Y., Zhu, Y., & Li, Y.-X. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01864-0 · Cited by 3

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusionPreprint

Lin, J. Q., Khuperkar, D., Pavlou, S., Makarchuk, S., Patikas, N., Lee, F. C. Y., Kang, J., Field, S. F., Zbiegly, J. M., Freeman, J. L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.27.514062 · Cited by 3

Effect of voluntary exercise on BDNF/TrkB gene expression and alcohol intake.

Jönsson, J. (2012) · DiVA (Linkoping University) · Cited by 3

Incidence of alternative splicing associated with sex and opioid effects in the axon guidance pathway

Southey, B. R., Sunderland, G. R., Gomez, A. N., Bhamidi, S., & Rodriguez‐Zas, S. L. (2025) · Gene · doi:10.1016/j.gene.2025.149215 · Cited by 2

Dexmedetomidine improves functional activity of dopaminergic neurons in MPTP-treated mice

Zou, W., Xie, Q., Ma, W., Li, S., Xu, Y., Chen, Y., Shen, H., Jiang, M. H., Ma, T., Dai, R., et al. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.06.059 · Cited by 2

Repeated Morphine Exposure Reversibly Impairs Spike Generation and Repetitive Firing in a Functionally Distinct Subpopulation of Orexin Neurons

Berry, E. A., Huhulea, E. N., Ishibashi, M., McGregor, R., Siegel, J. M., & Leonard, C. S. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0563-25.2025 · Cited by 3

The actions of morphine on microglia and the underlying effects on associated adverse effects

Wu, W., Li, Q., & Yang, F. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06956-y · Cited by 2

Effects of Syzygium aromaticum (clove) Extract on the Acquisition and Expression of Morphine-Induced Conditioned Place Preference in Swiss Albino Mice: an In vivo, In Silico Approach

Tithy, S. A., Hossain, M. M., Shill, D. K., Hossain, M. S., Islam, A., Molla, M. I., & Jahan, S. (2024) · Dhaka University Journal of Pharmaceutical Sciences · doi:10.3329/dujps.v23i1.74097 · Cited by 2

Atorvastatin facilitates extinction and prevents reinstatement of morphine-induced conditioned place preference in rats

Hashemizadeh, S., Alaee, E., Aghajani, N., Azizi, H., & Semnanian, S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117639 · Cited by 4

BDNF Val66Met polymorphism influence on striatal blood-level-dependent response to monetary feedback depends on valence and agency

Chumbley, J. R., Späti, J., Doerig, N., Brakowski, J., Holtforth, M. G., Seifritz, E., & Spinelli, S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.014 · Cited by 2

BDNF Pretreatment Attenuates Morphine-Induced Learning and Memory Impairment in Rats

Babaei, P., Vahdati, S., & Tehrani, B. S. (2015) · Caspian Journal of Neurological Sciences · doi:10.18869/acadpub.cjns.1.1.12 · Cited by 2

Opioid-Induced Adaptations of cAMP Dynamics in the Nucleus Accumbens

Zych, S. M., & Ford, C. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.01.004 · Cited by 2

Peptide Mimetic of BDNF Loop 4 Blocks Behavioral Signs of Morphine Withdrawal Syndrome and Prevents the Increase in ΔFosB Level in the Striatum of Rats

Колик, Л. Г., Konstantinopolsky, M. A., Надорова, А. В., Круглов, С. В., Антипова, Т. А., Гудашева, Т. А., & Середенин, С. Б. (2020) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-020-04998-0 · Cited by 2

Opioids

Koob, G. F., Arends, M. A., McCracken, M. L., & Moal, M. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-816988-9.00001-1 · Cited by 2

Novel Targets for Drug Treatment in Psychiatry

Kurita, M., García‐Bea, A., & González‐Maeso, J. (2016) · Springer eBooks · doi:10.1007/978-1-4939-2528-5_30 · Cited by 1

Dopamine D2 Receptors, D1/D2 Receptor Heteromers and CaMKII Signaling in the Neurobiology of Drug Addiction

Jia, W., He, X., Cheng, A., He, Y., Zhao, F., Fukunaga, K., & Zhao, W. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05963-0 · Cited by 1

Epigenetics and drug addiction: translational aspects

Feng, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800226-1.00017-4 · Cited by 1

Striatal circuits

Patton, M. S., & Mathur, B. N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823453-2.00010-2 · Cited by 1

Effects of Single Injections of Brain-Derived Neurotrophic Factors into the Midline Ventral Tegmental Area on the Reinforcing Properties of Morphine

Peregud, D., Stepanichev, M. Y., Лазарева, Н. А., Panchenko, L. F., & Gulyaeva, N. V. (2017) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-017-0540-x · Cited by 1

The Developmental Neuroepigenetics of Substance Abuse

Mason, B., Donaldson, S. T., & Hunter, R. G. (2018) · Journal of Drug and Alcohol Research · doi:10.4303/jdar/236039 · Cited by 1

The Role of the Dopamine D1-D2 Receptor Heteromer in Brain Reward Function: Relevance to Drug Addiction and Depression

Shen, Y. F. (2015) · TSpace (University of Toronto) · Cited by 1

Genetic and Pharmacologic Studies Towards Prevention of opioid use disorder

Kaski, S. W. (2019) · doi:10.33915/etd.4124 · Cited by 1

Heroin Self-Administration Induces Altered Dopamine Terminal Dynamics in the Nucleus AccumbensPreprint

George, B. E., Dawes, M. H., Peck, E. G., & Jones, S. R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.02.478890 · Cited by 1

Role of serum- and glucocorticoid-inducible kinase 1 (SGK1) in morphine and cocaine reward behaviors

Fallon, B. (2014) · Michigan State University Libraries · doi:10.25335/j786-7y39

Optogenetic Stimulation of Dopamine Afferents in Nucleus Accumbens and Central Amygdala Reveals Differential Roles in Food and Social Motivation

Hong, S. (2015) · Deep Blue (University of Michigan)

Science Signaling Podcast: 9 October 2012

Nestler, E. J., & VanHook, A. M. (2012) · Science Signaling · doi:10.1126/scisignal.2003551

Mu-Opioid Receptor - pAKT signaling in the Ventral Tegmental Area is Critical for the Behavioral and Cellular Consequences of Social Stress

Johnston, C. E. (2015)

Epigenetic Modifications of DNA and Drug Addiction

Feng, J., & Nestler, E. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801596-4.00008-3

Optogenetics and the Dissection of Neural Circuits Underlying Depression and Substance-use Disorders

Juarez, B., Friedman, A. K., & Han, M. (2017) · Cambridge University Press eBooks · doi:10.1017/9781107281875.020

Transdermal Fentanyl for Pain Management in Cancer Patients

Bista, S. R. (2015) · Griffith Research Online · doi:10.25904/1912/662

Neurobiology of depression: The role of glycogen synthase kinase 3

Sonawane, M., Aceto, G., Re, J. D., D’Ascenzo, M., Green, T. A., & Laezza, F. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817935-2.00011-8 · Cited by 1

A propósito de las propiedades rústicas y urbanas del colegio-convento "San Nicolás de Tolentino" de Alcalá de Henares en 1753

Calahorra, J. O. (2003) · Anales Complutenses

Faculty Opinions recommendation of Midbrain circuit regulation of individual alcohol drinking behaviors in mice.

Pandey, S. C. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732336900.793553551

Faculty Opinions recommendation of Midbrain circuit regulation of individual alcohol drinking behaviors in mice.

Kash, T., & Pina, M. M. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732336900.793552497

Serum Level of GDNF is Associated with Adherence to Methadone Maintenance Treatment

Afghani, A., Razaghi, E. M., Sisakht, R. R., Farhoudian, A., & Vousooghi, N. (2023) · Archives of Neuroscience · doi:10.5812/ans-139049

Lf-Dbs of the Ventral Striatum Shortens Persistence for Morphine Place Preference and Modulates Bdnf Expression in the Corticomesolimbic Reward SystemPreprint

Lloret-Torres, M. E., & Barreto-Estrada, J. L. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4921217

Chronic but not acute morphine exposure reversibly impairs spike generation and repetitive firing in a functionally distinct subpopulation of orexin neuronsPreprint

Berry, E. A., Huhulea, E. N., Ishibashi, M., McGregor, R., Siegel, J. M., & Leonard, C. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.20.644444

Genetic landscape of morphine response in BXD recombinant inbred mice

Yin, Q., Yang, X., Ju, S., He, H., Han, Z., Yu, C., Jia, S., Lü, L., Tian, G., Mi, J., et al. (2025) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2025.100535

Epigenetic Effects of Ethanol

Finegersh, A. (2014) · D-Scholarship@Pitt (University of Pittsburgh)

BDNF and NLRP3 signaling differentially regulate formation and retrieval of nitrous oxide (N2O)-related rewarding memory in dorsal hippocampus CA3 region

Shen, H., Shi, Y., Xu, J., Ren, Y., Xia, X., Zang, T., Cheng, Y., Zhang, J., Ma, T., & Yin, F. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116327

Implication of the laterodorsal tegmentum in adaptive and maladaptive stress responses

Broussot, L. (2020) · theses.fr (ABES) · doi:10.70675/39fe4c40z3f00z4570zb7b3ze438a205279c

Effects of MC-100093, GLT-1 enhancer, in mesolimbic brain regions of C57BL/6 mouse exposed to hydrocodone high-dose challenge using comprehensive laboratory monitoring system

Wong, W., Bhowmik, K. K., Childers, W. E., Abou-Gharbia, M. A., & Sari, Y. (2026) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2026.09.006

Anti-Addictive Effects of Astragalus Fasciculifolius Extract in a Mouse Stress-Induced Morphine Dependent Model

Azizi, F., Shahrani, N., Asgharzadeh, N., Anjomshoa, M., Bijad, E., Shahrani, D., Korrani, M. S., & Shahrani, M. (2026) · Journal of Shahrekord University of Medical Sciences · doi:10.34172/jsums.1109

Effects of brain-derived neurotrophic factor and adeno-associated viral vector on morphine-induced condition through target concentration changes in the ventral tegmental area and nucleus accumbens

Deng, L., Chu, Z., Liu, P., Li, B., Lei, G., Li, S., Ma, Y., & Dang, Y. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114385 · Cited by 8

BDNF-AAV has protective effects on morphine-induced conditioned place preference through BDNF, TrkB, and CREB concentration changes in the VTA and NAc

Deng, L., Chu, Z., Li, B., Liu, P., Lei, G., Yang, L., Zhang, L., Li, S., Wang, Y., & Dang, Y. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136701 · Cited by 6

Loss of BDNF Signaling in D1R-Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition

Koo, J. W., Lobo, M. K., Chaudhury, D., Labonté, B., Friedman, A. K., Heller, E. A., Peña, C. J., Han, M., & Nestler, E. J. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.118 · Cited by 99

RACK1 affects morphine reward via BDNF

Wan, L., Xie, Y., Su, L., Liu, Y., Wang, Y., & Wang, Z. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.045 · Cited by 32

Regulating Opioid Responses

Stern, P. R. (2012) · Science Signaling · doi:10.1126/scisignal.2003665