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BDNF Is a Negative Modulator of Morphine Action
Open accessAbstract
Regulating Opioid Responses: Different drugs of abuse are thought to highjack similar reward systems in the brain using common mechanisms. However, Koo et al. (p. 124 ) now observe that some of the neural mechanisms that regulate opiate reward can be both different and even opposite to those that regulate reward by stimulant drugs. While knockdown of brain-derived neurotrophic factor (BDNF) in the ventral tegmental area in mice antagonized the response to cocaine, the same manipulation strengthened the potential of opiates to increase dopamine neuron excitability. Optogenetic stimulation of dopaminergic terminals in the nucleus accumbens could counteract the effects of BDNF on morphine reward blockade.
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“TrkB is enriched in D2-MSNs and BDNF signaling through TrkB has different roles in NAc MSN subtypes in psychostimulant and opiate motivation (26, 70), but depression-related BDNF signaling in MSN subtypes is unclear.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [70]
In the citing paper
“TrkB is enriched in D2-MSNs and BDNF signaling through TrkB has different roles in NAc MSN subtypes in psychostimulant and opiate motivation (26, 70), but depression-related BDNF signaling in MSN subtypes is unclear.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [70]
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Metadata
- Authors
- Koo, J. W., Mazei-Robison, M. S., Chaudhury, D., Juarez, B., LaPlant, Q., Ferguson, D., Feng, J., Sun, H., Scobie, K. N., Damez-Werno, D., Crumiller, M., Ohnishi, Y. N., Ohnishi, Y. H., Mouzon, E., Dietz, D. M., Lobo, M. K., Neve, R. L., Russo, S. J., Han, M.-H., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
- Kurume University (JP)
- University at Buffalo, State University of New York (US)
- University of Maryland, Baltimore (US)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Nestler, Eric J.
- ORCID
- Venue
- Science
- Published
- 2012-10-05
- Volume
- 338
- Issue
- 6103
- Pages
- 124-128
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3547365
- OpenAlex
- W2080876332
- Cited by
- 189
- References
- 54
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 9 · 2023: 9 · 2022: 9 · 2021: 15 · 2020: 18 · 2019: 15 · 2018: 11 · 2017: 19 · 2016: 21 · 2015: 15 · 2014: 19 · 2013: 13 · 2012: 3
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Japan Society for the Promotion of Science (24591735)
- National Institute of Mental Health (R01MH092306, K99MH094405, T32MH087004)
- National Institute on Drug Abuse (P01DA008227, R01DA014133)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- brain-derived neurotrophic factor, morphine, opioid reward, ventral tegmental area, nucleus accumbens, chronic opioid exposure, neural adaptation, reward systems, gene expression regulation
- MeSH terms
- Animals, Dopamine, Gene Expression Regulation, Male, Mice, Inbred C57BL, Morphine, Morphine Dependence, Nucleus Accumbens, Photic Stimulation, Ventral Tegmental Area, Brain-Derived Neurotrophic Factor, Receptor, trkB, Mice, Gene Knockdown Techniques, Gene Knockout Techniques, Dopaminergic Neurons
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