The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia
Open accessAbstract
Sticky Mucus?: Mucus—experienced, for example, in the form of a runny nose or productive cough—is one of the tools the body uses to expel or prevent the uptake of foreign matter. In a number of diseases, a failure of the normal mucus-control system leads to obstructions of the airways and respiratory problems. Button et al. (p. 937 ; see the Perspective by Dickey ) examine the existing gel-on-liquid model, where the mucus is thought to sit on a watery periciliary layer around the beating lung cilia that has been used to explain the flow of mucus. A gel-on-brush model is proposed where the mucus sits on a brushlike periciliary layer. The key elements of this layer are membrane-tethered macromolecules that cause normal flow and clearance of mucus. When dehydrated, the interface is disrupted, preventing normal mucus motion.
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Citations
Cites
Mucus clearance as a primary innate defense mechanism for mammalian airways
Knowles, M. R., & Boucher, R. C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215217 · Cited by 1,054
Self-citationRapid transport of large polymeric nanoparticles in fresh undiluted human mucus
Lai, S. K., O'Hanlon, D. E., Harrold, S., Man, S. T., Wang, Y.-Y., Cone, R., & Hanes, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608611104 · Cited by 1,050
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier
Tang, B. C., Dawson, M., Lai, S. K., Wang, Y.-Y., Suk, J. S., Yang, M., Zeitlin, P., Boyle, M. P., Fu, J., & Hanes, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905998106 · Cited by 453
Submucosal glands and airway defense
Wine, J. J., & Joo, N. S. (2004) · Proceedings of the American Thoracic Society · doi:10.1513/pats.2306015 · Cited by 223
Cited by
Elborn, J. S. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00576-6 · Cited by 1,805
The gastrointestinal mucus system in health and disease
Johansson, M. E. V., Sjövall, H., & Hansson, G. C. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.35 · Cited by 1,438
Muc5b is required for airway defence
Roy, M. G., Livraghi-Butrico, A., Fletcher, A. A., McElwee, M. M., Evans, S. E., Boerner, R. M., Alexander, S. N., Bellinghausen, L. K., Song, A. S., Petrova, Y. M., et al. (2014) · Nature · doi:10.1038/nature12807 · Cited by 764
Self-citationShteinberg, M., Haq, I. J., Polineni, D., & Davies, J. C. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32542-3 · Cited by 682
Idiopathic pulmonary fibrosis: pathogenesis and management
Sgalla, G., Iovene, B., Calvello, M., Ori, M., Varone, F., & Richeldi, L. (2018) · Respiratory Research · doi:10.1186/s12931-018-0730-2 · Cited by 573
Metadata
- Authors
- Button, B., Cai, L.-H., Ehre, C., Kesimer, M., Hill, D. B., Sheehan, J. K., Boucher, R. C., & Rubinstein, M.
- Venue
- Science
- Published
- 2012-08-24
- Volume
- 337
- Issue
- 6097
- Pages
- 937-941
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978811535
- Cited by
- 863
- References
- 4
- FWCI
- 35.34
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Button, B., Cai, L.-H., Ehre, C., Kesimer, M., Hill, D. B., Sheehan, J. K., Boucher, R. C., & Rubinstein, M. (2012). A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia. Science. https://doi.org/10.1126/science.1223012
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
