The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Wnt5a Potentiates TGF-β Signaling to Promote Colonic Crypt Regeneration After Tissue Injury
Open accessAbstract
Gut, Heal Thyself: Foods, drugs, and pathogens all represent possible threats to our guts on a daily basis. Fortunately, the gut is quite good at repairing itself—but how? Working in mice, Miyoshi et al. (p. 108 , published online 6 September; see the Perspective by Barrett ) selectively injured intestinal crypts containing intestinal stem cells and observed therepair process. The noncanonical Wnt ligand, Wnt5a, was required for crypt regeneration. Wnt5a inhibited intestinal stem cell proliferation, which paradoxically promoted regeneration of crypt tissue.
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Reparative inflammation takes charge of tissue regeneration
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The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites
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Self-citationSubchondral bone microenvironment in osteoarthritis and pain
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Metadata
- Authors
- Miyoshi, H., Ajima, R., Luo, C. T., Yamaguchi, T. P., & Stappenbeck, T. S.
- Venue
- Science
- Published
- 2012-10-05
- Volume
- 338
- Issue
- 6103
- Pages
- 108-113
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979475230
- Cited by
- 475
- References
- 9
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Wnt5a Potentiates TGF-β Signaling to Promote Colonic Crypt Regeneration After Tissue Injury. https://app.cochat.ai/papers/10.1126/science.1223821
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- Miyoshi, H., Ajima, R., Luo, C. T., Yamaguchi, T. P., & Stappenbeck, T. S. (2012). Wnt5a Potentiates TGF-β Signaling to Promote Colonic Crypt Regeneration After Tissue Injury. Science. https://doi.org/10.1126/science.1223821
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