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Cited by 767Wound Healing and TreatmentsLiver physiology and pathologyWnt/β-catenin signaling in development and cancer

Reparative inflammation takes charge of tissue regeneration

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Karin, Michael, Clevers, Hans·2016·Nature
DOI 10.1038/nature17039PMC PMC5228603
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Abstract

Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.

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Authors
Karin, M., & Clevers, H.
Affiliations
  • University of California San Diego (US)
  • University Medical Center Utrecht (NL)
Corresponding author
  • Karin, Michael
  • Clevers, Hans
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2016-01
Volume
529
Issue
7586
Pages
307-315
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature17039
PMC
PMC5228603
OpenAlex
W2299393419
Cited by
767
References
18
Citations by year
2026: 50 · 2025: 81 · 2024: 69 · 2023: 73 · 2022: 95 · 2021: 91 · 2020: 88 · 2019: 70 · 2018: 69 · 2017: 55 · 2016: 26
FWCI
9.30
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • Utrecht University Repository (Utrecht University) (submittedVersion)
Funders
National Institute of Environmental Health Sciences (P42ES010337)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Keywords
tissue regeneration, tissue repair, inflammatory cytokines, Wnt signaling, intestinal regeneration, liver regeneration, degenerative diseases
MeSH terms
Animals, Drosophila melanogaster, Humans, Inflammation, Regeneration, Therapeutics, Wound Healing, Signal Transduction, Cytokines, Microbiota

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