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Parallel Molecular Evolution in an Herbivore Community

Zhen, Ying, Aardema, Matthew L., Medina, Edgar M., Schumer, Molly, Andolfatto, Peter·2012·Science
DOI 10.1126/science.1226630PMC PMC3770729
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Abstract

Making the Change: The Apocynaceae plant family produces toxic cardenolids. However, many insects have managed to escape the deleterious effects of these chemicals and even, in some cases, use them in their own defense. Zhen et al. (p. 1634 ) investigated a broad range of taxa and found several examples of parallel changes, as well as duplications, in members of the ATPα family that likely explain the shift to allow insects to avoid the toxic effects of these plants. Thus, natural selection can harness a combination of gene duplication, protein evolution, and regulatory evolution to allow distantly related species to adapt to specific niches.

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  • Identical substitutions at the same nucleotide position or amino acid may cause identical phenotypic changes, such as resistance to a common toxin.

    “For instance, identical substitutions (or insertions/deletions) at the same nucleotide position or amino acid may cause identical phenotypic changes (Fig. 2a), such as resistances to a common toxin (Zhen et al. 2012).”

    From From Trees to Traits: A Review of Advances in PhyloG2P Methods and Future Directions (2025) · cites this paper as Zhen et al. 2012

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Metadata

Authors
Zhen, Y., Aardema, M. L., Medina, E. M., Schumer, M., & Andolfatto, P.
Affiliations
  • Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA.
  • Departamento de Ciencias Biológicas, Universidad de los Andes, Bogotá 11001, Colombia.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2012-09-28
Volume
337
Issue
6102
Pages
1634-1637
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1226630
PMC
PMC3770729
Cited by
288
References
5
Language
en

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