The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Bacterial Quorum Sensing and Metabolic Incentives to Cooperate
Open accessAbstract
Cheat Control: In quorum-sensing induction, a Pseudomonas aeruginosa population growing on a single carbon source, such as casein, will reach a density where the levels of signaling molecules they collectively secrete triggers the cells to synthesize and secrete proteases to digest the casein. However, it is metabolically costly to secrete proteases, and the system is prone to mutant “cheats.” These cheats do not respond to quorum sensing and do not go to the cost of synthesizing protease, but they do profit from the breakdown products that allow all the cells—cheats and cooperators alike—to grow. Dandekar et al. (p. 264 ) found that quorum signaling–insensitive P. aeruginosa cheats could not synthesize nucleotide hydrolase and were thus unable to grow if casein was replaced by adenosine. This allowed cooperators to outgrow the cheats, leading to a stable equilibrium between cheats and cooperators. This principle of regulation may be applicable to other bacterial quorum-sensing systems and might be exploited in the development of drugs that disrupt bacterial cooperation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
QUORUM SENSING: Cell-to-Cell Communication in Bacteria
Waters, C. M., & Bassler, B. L. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131001 · Cited by 3,979
Fuqua, W. C., Winans, S. C., & Greenberg, E. P. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.2.269-275.1994 · Cited by 2,927
Self-citationQuorum-sensing in Gram-negative bacteria
Whitehead, N. (2001) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(01)00059-6 · Cited by 1,607
Schuster, M., Lostroh, C. P., Ogi, T., & Greenberg, E. P. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.7.2066-2079.2003 · Cited by 1,126
Self-citationRegulation of las and rhl quorum sensing in Pseudomonas aeruginosa
Pesci, E. C., Pearson, J. P., Seed, P. C., & Iglewski, B. H. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.10.3127-3132.1997 · Cited by 889
Cooperation and conflict in quorum-sensing bacterial populations
Diggle, S. P., Griffin, A. S., Campbell, G. S., & West, S. A. (2007) · Nature · doi:10.1038/nature06279 · Cited by 837
Cooperation and Competition Between Relatives
West, S. A., Pen, I., & Griffin, A. S. (2002) · Science · doi:10.1126/science.1065507 · Cited by 798
A network of networks: Quorum-sensing gene regulation in Pseudomonas aeruginosa
Schuster, M., & Peter Greenberg, E. (2006) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2006.01.036 · Cited by 646
Evolution of cooperation and conflict in experimental bacterial populations
Rainey, P. B., & Rainey, K. (2003) · Nature · doi:10.1038/nature01906 · Cited by 582
Brint, J. M., & Ohman, D. E. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.24.7155-7163.1995 · Cited by 566
Cited by
Control of bacterial metabolism by quorum sensing
Goo, E., An, J. H., Kang, Y., & Hwang, I. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.05.007 · Cited by 155
Gallium-mediated siderophore quenching as an evolutionarily robust antibacterial treatment
Ross-Gillespie, A., Weigert, M., Brown, S. P., & Kümmerli, R. (2014) · Evolution, Medicine, and Public Health · doi:10.1093/emph/eou003 · Cited by 104
Community diversity and habitat structure shape the repertoire of extracellular proteins in bacteria
Garcia-Garcera, M., & Rocha, E. P. C. (2020) · Nature Communications · doi:10.1038/s41467-020-14572-x · Cited by 39
Surfactin Facilitates Horizontal Gene Transfer in Bacillus subtilis
Danevčič, T., Dragoš, A., Spacapan, M., Stefanic, P., Dogsa, I., & Mandic-Mulec, I. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.657407 · Cited by 35
Sathe, S., Mathew, A., Agnoli, K., Eberl, L., & Kümmerli, R. (2019) · Evolution Letters · doi:10.1002/evl3.144 · Cited by 23
Metadata
- Authors
- Dandekar, A. A., Chugani, S., & Greenberg, E. P.
- Venue
- Science
- Published
- 2012-10-12
- Volume
- 338
- Issue
- 6104
- Pages
- 264-266
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979888857
- Cited by
- 332
- References
- 21
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Bacterial Quorum Sensing and Metabolic Incentives to Cooperate. https://app.cochat.ai/papers/10.1126/science.1227289
- The paper
- Dandekar, A. A., Chugani, S., & Greenberg, E. P. (2012). Bacterial Quorum Sensing and Metabolic Incentives to Cooperate. Science. https://doi.org/10.1126/science.1227289
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
