The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy
Open accessAbstract
Red in Cell and Marrow: About one hundred billion new red cells are released every day from the adult human bone marrow—the result of a complex differentiation pathway. Barde et al. (p. 350 , published online 14 March) show that an essential step in this process, the elimination of mitochondria from maturing erythroblasts through mitophagy, is controlled through the timely induction of specific members of the large family of KRAB-containing zinc finger proteins (KRAB-ZFPs), which, together with their cofactor KAP1, repress the expression of micro-RNAs targeting the transcripts of mitophagy effector genes. This multilayered and combinatorial regulation system provides a level of modularity that may be shared by other physiological processes.
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“miR-351 and miR-125a are also known to regulate mitophagy [49].”
From miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) (2016) · cites this paper as [49]
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Cites
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581
The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
The Sequence of the Human Genome
Venter, J. C., Smith, H. O., & Adams, M. D. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2014.237016 · Cited by 1,665
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,641
A census of human transcription factors: function, expression and evolution
Vaquerizas, J. M., Kummerfeld, S. K., Teichmann, S. A., & Luscombe, N. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2538 · Cited by 1,573
Roles for MicroRNAs in Conferring Robustness to Biological Processes
Ebert, M. S., & Sharp, P. A. (2012) · Cell · doi:10.1016/j.cell.2012.04.005 · Cited by 1,564
Research works printed but not linked: 4
- 10.1038/nature01262 · DOI · Paper page
- 10.1038/nature01262 · DOI · Paper page
- 10.1016/j.cell.2007.07.026 · DOI
- 10.1016/j.devcel.2008.08.014 · DOI
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Hamacher‐Brady, A., & Brady, N. R. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2087-8 · Cited by 410
Ecco, G., Imbeault, M., & Trono, D. (2017) · Development · doi:10.1242/dev.132605 · Cited by 413
Self-citationRegulation of microRNA function in somatic stem cell proliferation and differentiation
Shenoy, A., & Blelloch, R. H. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3854 · Cited by 357
From Erythroblasts to Mature Red Blood Cells: Organelle Clearance in Mammals
Moras, M., Lefevre, S. D., & Ostuni, M. A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01076 · Cited by 364
Metadata
- Authors
- Barde, I., Rauwel, B., Marin-Florez, R. M., Corsinotti, A., Laurenti, E., Verp, S., Offner, S., Marquis, J., Kapopoulou, A., Vanicek, J., & Trono, D.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- School of Basic Sciences, EPFL, 1015 Lausanne, Switzerland.
- Corresponding author
- Trono, Didier
- ORCID
- Venue
- Science
- Published
- 2013-04-19
- Volume
- 340
- Issue
- 6130
- Pages
- 350-353
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3678075
- OpenAlex
- W1989966286
- Cited by
- 111
- References
- 39
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 11 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 17 · 2013: 6
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
- IRIS (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Science Foundation
- Cincinnati Children's Hospital Medical Center
- École Polytechnique Fédérale de Lausanne
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- KRAB zinc finger proteins, KAP1, mitophagy, erythropoiesis, microRNA regulation, erythroblasts, hypoproliferative anemia, hematopoiesis, transcriptional repression, chromatin modifiers, mitochondrial clearance
- MeSH terms
- Tripartite Motif-Containing Protein 28, Anemia, Animals, Autophagy, Erythroblasts, Erythropoiesis, Female, Male, Membrane Proteins, Mice, Inbred C57BL, Mitochondria, Nuclear Proteins, Repressor Proteins, Transcription Factors, Zinc Fingers, Mice, Knockout, Mitochondrial Proteins, MicroRNAs, Mice
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