The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy
Open accessAbstract
Red in Cell and Marrow: About one hundred billion new red cells are released every day from the adult human bone marrow—the result of a complex differentiation pathway. Barde et al. (p. 350 , published online 14 March) show that an essential step in this process, the elimination of mitochondria from maturing erythroblasts through mitophagy, is controlled through the timely induction of specific members of the large family of KRAB-containing zinc finger proteins (KRAB-ZFPs), which, together with their cofactor KAP1, repress the expression of micro-RNAs targeting the transcripts of mitophagy effector genes. This multilayered and combinatorial regulation system provides a level of modularity that may be shared by other physiological processes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“miR-351 and miR-125a are also known to regulate mitophagy [49].”
From miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) (2016) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581
The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
The Sequence of the Human Genome
Venter, J. C., Smith, H. O., & Adams, M. D. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2014.237016 · Cited by 1,665
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,641
A census of human transcription factors: function, expression and evolution
Vaquerizas, J. M., Kummerfeld, S. K., Teichmann, S. A., & Luscombe, N. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2538 · Cited by 1,573
Roles for MicroRNAs in Conferring Robustness to Biological Processes
Ebert, M. S., & Sharp, P. A. (2012) · Cell · doi:10.1016/j.cell.2012.04.005 · Cited by 1,564
IFNα activates dormant haematopoietic stem cells in vivo
Essers, M. A. G., Offner, S., Blanco-Bose, W. E., Waibler, Z., Kalinke, U., Duchosal, M. A., & Trumpp, A. (2009) · Nature · doi:10.1038/nature07815 · Cited by 1,368
Self-citationSchultz, D. C., Ayyanathan, K., Negorev, D., Maul, G. G., & Rauscher, F. J. (2002) · Genes & Development · doi:10.1101/gad.973302 · Cited by 1,313
PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
Shin, J.-H., Ko, H. S., Kang, H., Lee, Y., Lee, Y.-I., Pletinkova, O., Troconso, J. C., Dawson, V. L., & Dawson, T. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.010 · Cited by 953
KAP1 controls endogenous retroviruses in embryonic stem cells
Rowe, H. M., Jakobsson, J., Mesnard, D., Rougemont, J., Reynard, S., Aktas, T., Maillard, P. V., Layard-Liesching, H., Verp, S., Marquis, J., et al. (2010) · Nature · doi:10.1038/nature08674 · Cited by 874
Self-citationZiv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D. C., Lukas, J., Bekker-Jensen, S., Bartek, J., & Shiloh, Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1446 · Cited by 735
A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints
Li, X., Ito, M., Zhou, F., Youngson, N. A., Zuo, X., Leder, P., & Ferguson‐Smith, A. C. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.08.014 · Cited by 647
HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression
Martin, P. J., & Papayannopoulou, T. (1982) · Science · doi:10.1126/science.6177045 · Cited by 608
Schultz, D., Friedman, J. R., & Rauscher, F. J. (2001) · Genes & Development · doi:10.1101/gad.869501 · Cited by 530
Mackay, D., Callaway, J. L. A., Marks, S. M., White, H., Acerini, C. L., Boonen, S. E., Dayanıklı, P., Firth, H. V., Goodship, J. A., Haemers, A. P., et al. (2008) · Nature Genetics · doi:10.1038/ng.187 · Cited by 527
Hattangadi, S. M., Wong, P., Zhang, L., Flygare, J., & Lodish, H. F. (2011) · Blood · doi:10.1182/blood-2011-07-356006 · Cited by 423
Bellefroid, E., Poncelet, D. A., Lecocq, P. J., Revelant, O., & MARTIAL, J. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3608 · Cited by 375
Nielsen, A. L., Ortiz, J. A., You, J., Oulad‐Abdelghani, M., Khechumian, R., Gansmuller, A., Chambon, P., & Losson, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6385 · Cited by 361
TRIM28 Mediates Primer Binding Site-Targeted Silencing of Murine Leukemia Virus in Embryonic Cells
Wolf, D., & Goff, S. P. (2007) · Cell · doi:10.1016/j.cell.2007.07.026 · Cited by 348
Zheng, L., Pan, H., Li, S., Flesken‐Nikitin, A., Chen, P., Boyer, T., & Lee, W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00075-7 · Cited by 232
Cammas, F. M., Mark, M. P., Dollé, P., Dierich, A., Chambon, P., & Losson, R. (2000) · Development · doi:10.1242/dev.127.13.2955 · Cited by 212
Xu, J., Shao, Z., Glass, K., Bauer, D. E., Pinello, L., Handel, B. V., Hou, S., Stamatoyannopoulos, J. A., Mikkola, H. K. A., Yuan, G., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.09.003 · Cited by 207
Rowe, H. M., Kapopoulou, A., Corsinotti, A., Fasching, L., Macfarlan, T. S., Tarabay, Y., Viville, S., Jakobsson, J., Pfaff, S. L., & Trono, D. (2012) · Genome Research · doi:10.1101/gr.147678.112 · Cited by 190
Self-citationQuenneville, S., Turelli, P., Bojkowska, K., Raclot, C., Offner, S., Kapopoulou, A., & Trono, D. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.08.043 · Cited by 160
Self-citationEfficient use of accessibility in microRNA target prediction
Marín, R. M., & Vaníček, J. J. L. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq768 · Cited by 151
KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress
Jakobsson, J., Cordero, M. I., Bisaz, R., Groner, A. C., Busskamp, V., Bensadoun, J., Cammas, F. M., Losson, R., Mansuy, I. M., Sandi, C., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.036 · Cited by 134
Self-citationTRIM28 prevents autoinflammatory T cell development in vivo
Chikuma, S., Suita, N., Okazaki, I., Shibayama, S., & Honjo, T. (2012) · Nature Immunology · doi:10.1038/ni.2293 · Cited by 105
KAP1 regulates gene networks controlling T‐cell development and responsiveness
de Sio, F. R. S., Barde, I., Offner, S., Kapopoulou, A., Corsinotti, A., Bojkowska, K., Genolet, R., Thomas, J. H., Luescher, I. F., Pinschewer, D. D., et al. (2012) · The FASEB Journal · doi:10.1096/fj.12-206177 · Cited by 56
Self-citationBojkowska, K., Aloisio, F., Cassano, M., Kapopoulou, A., de Sio, F. R. S., Zangger, N., Offner, S., Cartoni, C., Thomas, C., Quenneville, S., et al. (2012) · Hepatology · doi:10.1002/hep.25767 · Cited by 54
Self-citationmicroRNA expression in erythropoiesis and erythroid disorders
Lawrie, C. H. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07978.x · Cited by 54
KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function
de Sio, F. R. S., Massacand, J. C., Barde, I., Offner, S., Corsinotti, A., Kapopoulou, A., Bojkowska, K., Dagklis, A., Fernandez, M., Ghia, P., et al. (2012) · Blood · doi:10.1182/blood-2011-12-401117 · Cited by 50
Self-citationBarde, I., Laurenti, E., Verp, S., Wiznerowicz, M., Offner, S., Viornery, A., Galy, A. H. M., Trumpp, A., & Trono, D. (2011) · Gene Therapy · doi:10.1038/gt.2011.65 · Cited by 47
Self-citationGETPrime: a gene- or transcript-specific primer database for quantitative real-time PCR
Gubelmann, C., Gattiker, A., Massouras, A., Hens, K., David, F. P. A., Decouttere, F., Rougemont, J., & Deplancke, B. (2011) · Database · doi:10.1093/database/bar040 · Cited by 46
Meylan, S., Groner, A. C., Ambrosini, G., Malani, N., Quenneville, S., Zangger, N., Kapopoulou, A., Kauzlaric, A., Rougemont, J., Ciuffi, A., et al. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-378 · Cited by 27
Self-citationOptimal Use of Conservation and Accessibility Filters in MicroRNA Target Prediction
Marín, R. M., & Vaníček, J. J. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032208 · Cited by 25
Flagged first, then by citations
Research works printed but not linked: 4
- 10.1038/nature01262 · DOI · Paper page
- 10.1038/nature01262 · DOI · Paper page
- 10.1016/j.cell.2007.07.026 · DOI
- 10.1016/j.devcel.2008.08.014 · DOI
Cited by
Sorted by citations
TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis
Hatakeyama, S. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.01.002 · Cited by 955
Hamacher‐Brady, A., & Brady, N. R. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2087-8 · Cited by 410
Ecco, G., Imbeault, M., & Trono, D. (2017) · Development · doi:10.1242/dev.132605 · Cited by 413
Self-citationRegulation of microRNA function in somatic stem cell proliferation and differentiation
Shenoy, A., & Blelloch, R. H. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3854 · Cited by 357
From Erythroblasts to Mature Red Blood Cells: Organelle Clearance in Mammals
Moras, M., Lefevre, S. D., & Ostuni, M. A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01076 · Cited by 364
Metadata
- Authors
- Barde, I., Rauwel, B., Marin-Florez, R. M., Corsinotti, A., Laurenti, E., Verp, S., Offner, S., Marquis, J., Kapopoulou, A., Vanicek, J., & Trono, D.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- School of Basic Sciences, EPFL, 1015 Lausanne, Switzerland.
- Corresponding author
- Trono, Didier
- ORCID
- Venue
- Science
- Published
- 2013-04-19
- Volume
- 340
- Issue
- 6130
- Pages
- 350-353
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3678075
- OpenAlex
- W1989966286
- Cited by
- 111
- References
- 39
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 11 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 17 · 2013: 6
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
- IRIS (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Science Foundation
- Cincinnati Children's Hospital Medical Center
- École Polytechnique Fédérale de Lausanne
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- KRAB zinc finger proteins, KAP1, mitophagy, erythropoiesis, microRNA regulation, erythroblasts, hypoproliferative anemia, hematopoiesis, transcriptional repression, chromatin modifiers, mitochondrial clearance
- MeSH terms
- Tripartite Motif-Containing Protein 28, Anemia, Animals, Autophagy, Erythroblasts, Erythropoiesis, Female, Male, Membrane Proteins, Mice, Inbred C57BL, Mitochondria, Nuclear Proteins, Repressor Proteins, Transcription Factors, Zinc Fingers, Mice, Knockout, Mitochondrial Proteins, MicroRNAs, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review