The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species
Abstract
Antibiotic Mechanisms Revisited: Several recent studies have suggested that bactericidal antibiotics kill cells by a common mechanism involving reactive oxygen species (ROS). Two groups tested this hypothesis using diverse experiments, with both finding that quinolone, lactam, and aminoglycoside antibiotics had similar efficacy for killing in the presence or absence of oxygen (or nitrate). Liu et al. (p. 1210 ) saw no increase in hydrogen peroxide production in antibiotic-exposed cells and found no association between antibiotic exposure and the expected symptoms of oxidative damage, such as the breakdown of iron-sulfur clusters in enzymes or of hydroxyl radical injuries to DNA. Similarly, Keren et al. (p. 1213 ) found no correlation between the production of ROS, inferred from hydroxyphenyl fluorescein dye measurements, and bacterial survival, nor was there any significant protective effect engendered by thiourea. The results do not support a common mode of action for bactericidal antibiotics mediated by ROS.
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Citations
Cites
Determination of minimum inhibitory concentrations
Andrews, J. M. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.suppl_1.5 · Cited by 4,129
Lewis, K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134306 · Cited by 1,858
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Cited by
Beyond oxidative stress: an immunologist's guide to reactive oxygen species
Nathan, C., & Cunningham-Bussel, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3423 · Cited by 1,619
Reactive Oxygen Species-Related Nanoparticle Toxicity in the Biomedical Field
Yu, Z., Li, Q., Wang, J., Yu, Y., Wang, Y., Zhou, Q., & Li, P. (2020) · Nanoscale Research Letters · doi:10.1186/s11671-020-03344-7 · Cited by 709
ROS and diseases: role in metabolism and energy supply
Yang, S., & Lian, G. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03667-9 · Cited by 658
Post-stress bacterial cell death mediated by reactive oxygen species
Hong, Y., Zeng, J., Wang, X., Drlica, K., & Zhao, X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901730116 · Cited by 513
ATP-Dependent Persister Formation in Escherichia coli
Shan, Y., Brown Gandt, A., Rowe, S. E., Deisinger, J. P., Conlon, B. P., & Lewis, K. (2017) · mBio · doi:10.1128/mbio.02267-16 · Cited by 508
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Metadata
- Authors
- Keren, I., Wu, Y., Inocencio, J., Mulcahy, L. R., & Lewis, K.
- Venue
- Science
- Published
- 2013-03-08
- Volume
- 339
- Issue
- 6124
- Pages
- 1213-1216
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081851349
- Cited by
- 550
- References
- 2
- FWCI
- 42.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Keren, I., Wu, Y., Inocencio, J., Mulcahy, L. R., & Lewis, K. (2013). Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species. Science. https://doi.org/10.1126/science.1232688
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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