The DOI matches its Crossref record; 189 of the 189 references it cites were found in a registry or an index.
Reactive Oxygen Species-Related Nanoparticle Toxicity in the Biomedical Field
Open accessAbstract
The unique physicochemical characteristics of nanoparticles have recently gained increasing attention in a diverse set of applications, particularly in the biomedical field. However, concerns about the potential toxicological effects of nanoparticles remain, as they have a higher tendency to generate excessive amounts of reactive oxygen species (ROS). Due to the strong oxidation potential, the excess ROS induced by nanoparticles can result in the damage of biomolecules and organelle structures and lead to protein oxidative carbonylation, lipid peroxidation, DNA/RNA breakage, and membrane structure destruction, which further cause necrosis, apoptosis, or even mutagenesis. This review aims to give a summary of the mechanisms and responsible for ROS generation by nanoparticles at the cellular level and provide insights into the mechanics of ROS-mediated biotoxicity. We summarize the literature on nanoparticle toxicity and suggest strategies to optimize nanoparticles for biomedical applications.
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1 retracted
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Cited by
Abbasi, R., Shineh, G., Mobaraki, M., Doughty, S., & Tayebi, L. (2023) · Journal of Nanoparticle Research · doi:10.1007/s11051-023-05690-w · Cited by 623
Hersh, A. M., Alomari, S., & Tyler, B. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084153 · Cited by 478
Tian, H., Zhang, T., Qin, S., Huang, Z., Zhou, L., Shi, J., Nice, E. C., Xie, N., Huang, C., & Shen, Z. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01320-5 · Cited by 426
Toxicity of metal–organic framework nanoparticles: from essential analyses to potential applications
Ettlinger, R., Lächelt, U., Gref, R., Horcajada, P., Lammers, T., Serre, C., Couvreur, P., Morris, R. E., & Wuttke, S. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00918d · Cited by 423
Kus-Liśkiewicz, M., Fickers, P., & Ben Tahar, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010952 · Cited by 404
Metadata
- Authors
- Yu, Z., Li, Q., Wang, J., Yu, Y., Wang, Y., Zhou, Q., & Li, P.
- Venue
- Nanoscale Research Letters
- Published
- 2020-05-20
- Volume
- 15
- Issue
- 1
- Pages
- 115-115
- ISSN
- 1556-276X (ISSN-L)
- OpenAlex
- W3028148512
- Cited by
- 709
- References
- 189
- FWCI
- 32.35
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yu, Z., Li, Q., Wang, J., Yu, Y., Wang, Y., Zhou, Q., & Li, P. (2020). Reactive Oxygen Species-Related Nanoparticle Toxicity in the Biomedical Field. Nanoscale Research Letters. https://doi.org/10.1186/s11671-020-03344-7
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