The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Deep Cortical Layers Are Activated Directly by Thalamus
Open accessAbstract
A Direct Line in the Brain: For decades, neuroscientists have assumed that there is a “canonical microcircuit” in the neo cortex, in which information is transformed as excitation spreads serially along connections from thalamus, to cortical layer 4, then to layers 2/3, to layers 5/6, and finally to other brain regions. Each cortical layer is thought to transform sensory signals to extract behaviorally relevant information. Now, Constantinople and Bruno (p. 1591 ) challenge this dogma. In vivo whole-cell recordings revealed that sensory stimuli activate neurons in deep cortical layers simultaneously to those in layer 4 and that a large number of thalamic neurons converge onto deep pyramidal neurons, possibly allowing sensory information to completely bypass upper layers. Temporary blockade of layer 4 revealed that synaptic input to deep cortical layers derived entirely from the thalamus and not at all from upper cortical layers. This thalamically derived synaptic input reliably drove pyramidal neurons in layer 5 to discharge action potentials in the living animal. These deep layer neurons project to numerous higher-order brain regions and could directly mediate behavior.
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NEURONAL CIRCUITS OF THE NEOCORTEX
Douglas, R. J., & Martin, K. A. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144152 · Cited by 1,886
Modulation of visual responses by behavioral state in mouse visual cortex
Niell, C. M., & Stryker, M. P. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.033 · Cited by 1,483
Gilbert, C. D., & Wiesel, T. N. (1979) · Nature · doi:10.1038/280120a0 · Cited by 1,012
Cortex is driven by weak but synchronously active thalamocortical synapses
Bruno, R. M., & Sakmann, B. (2006) · Science · doi:10.1126/science.1124593 · Cited by 714
Self-citationSensorimotor mismatch signals in primary visual cortex of the behaving mouse
Keller, G. B., Bonhoeffer, T., & Hübener, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.040 · Cited by 668
Thalamic Relay Functions and Their Role in Corticocortical Communication
Guillery, R. W., & Sherman, S. M. (2002) · Neuron · doi:10.1016/s0896-6273(01)00582-7 · Cited by 636
Laminar Organization of Thalamic Projections to the Rat Neocortex
Herkenham, M. (1980) · Science · doi:10.1126/science.7352263 · Cited by 592
Sparse Representation of Sounds in the Unanesthetized Auditory Cortex
Hromádka, T., DeWeese, M. R., & Zador, A. M. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060016 · Cited by 579
Visual response latencies in striate cortex of the macaque monkey
Maunsell, J. H., & Gibson, J. R. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.68.4.1332 · Cited by 554
Neural Activity in Barrel Cortex Underlying Vibrissa-Based Object Localization in Mice
O'Connor, D. H., Peron, S. P., Huber, D., & Svoboda, K. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.026 · Cited by 469
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Reconstruction and Simulation of Neocortical Microcircuitry
Markram, H., Muller, E., Ramaswamy, S., Reimann, M. W., Abdellah, M., Sanchez, C. A., Ailamaki, A., Alonso-Nanclares, L., Antille, N., Arsever, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.029 · Cited by 1,557
The neocortical circuit: themes and variations
Harris, K. D., & Shepherd, G. M. G. (2015) · Nature Neuroscience · doi:10.1038/nn.3917 · Cited by 1,215
The connectome of an insect brain
Winding, M., Pedigo, B. D., Barnes, C. L., Patsolic, H. G., Park, Y., Kazimiers, T., Fushiki, A., Andrade, I. V., Khandelwal, A., Valdes-Aleman, J., et al. (2023) · Science · doi:10.1126/science.add9330 · Cited by 435
A Top-Down Cortical Circuit for Accurate Sensory Perception
Manita, S., Suzuki, T., Homma, C., Matsumoto, T., Odagawa, M., Yamada, K., Ota, K., Matsubara, C., Inutsuka, A., Sato, M., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.006 · Cited by 365
Cellular Mechanisms of Conscious Processing
Aru, J., Suzuki, M., & Larkum, M. E. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.07.006 · Cited by 321
“The basal compartment mainly receives feedforward input from specific areas lower in the processing hierarchy [43,44], although it can also receive long-range feedback input [45,46].”
Background
Metadata
- Authors
- Constantinople, C. M., & Bruno, R. M.
- Venue
- Science
- Published
- 2013-06-28
- Volume
- 340
- Issue
- 6140
- Pages
- 1591-1594
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2041918412
- Cited by
- 484
- References
- 35
- FWCI
- 22.72
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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