The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells
Open accessAbstract
DNA Damage Repair: In human cancers, oncogene activation interferes with DNA replication, leading to DNA replication stress and DNA double-strand breaks (DSBs). Costantino et al. (p. 88 , published online 5 December) identified two subunits of DNA polymerase delta, POL3 and POL4, as critical for survival of DNA replication stress in human cells. Both subunits were required for break-induced replication (BIR), which is required to repair a specific type of DSB, with both subunits possibly required for processive DNA synthesis in BIR. Tandem head-to-tail duplications and fold-back inversions were seen in replication-stressed cells, similar to those seen in human breast and ovarian cancers, suggesting that BIR is important for repairing damaged forks in cancer cells.
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Carvalho, C. M. B., & Lupski, J. R. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2015.25 · Cited by 774
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Inflammation-Induced Cell Proliferation Potentiates DNA Damage-Induced Mutations In Vivo
Kiraly, O., Gong, G., Olipitz, W., Muthupalani, S., & Engelward, B. P. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1004901 · Cited by 169
Popova, T., Manié, E., Boeva, V., Battistella, A., Goundiam, O., Smith, N. K., Mueller, C. R., Raynal, V., Mariani, O., Sastre-Garau, X., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2128 · Cited by 130
Metadata
- Authors
- Costantino, L., Sotiriou, S. K., Rantala, J. K., Magin, S., Mladenov, E., Helleday, T., Haber, J. E., Iliakis, G., Kallioniemi, O. P., & Halazonetis, T. D.
- Venue
- Science
- Published
- 2014-01-03
- Volume
- 343
- Issue
- 6166
- Pages
- 88-91
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067573570
- Cited by
- 461
- References
- 8
- FWCI
- 15.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Costantino, L., Sotiriou, S. K., Rantala, J. K., Magin, S., Mladenov, E., Helleday, T., Haber, J. E., Iliakis, G., Kallioniemi, O. P., & Halazonetis, T. D. (2014). Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells. Science. https://doi.org/10.1126/science.1243211
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