The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Hepatitis C Virus E2 Envelope Glycoprotein Core Structure
Open accessAbstract
Deciphering Hepatitis C: Hepatitis C virus is a major cause of liver disease and cancer. Two envelope glycoproteins, E1 and E2, form a heterodimer that facilitates infection. The envelope proteins have been difficult to crystallize, hindering vaccine development. Kong et al. (p. 1090 ) designed an E2 core glycoprotein construct and solved the crystal structure of the glycosylated protein in complex with a broadly neutralizing antibody. The host cell receptor binding site was identified by electron microscopy and mutagenesis. The findings should help in future drug and vaccine design.
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Immune responses and immunopathology in acute and chronic viral hepatitis
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Metadata
- Authors
- Kong, L., Giang, E., Nieusma, T., Kadam, R. U., Cogburn, K. E., Hua, Y., Dai, X., Stanfield, R. L., Burton, D. R., Ward, A. B., Wilson, I. A., & Law, M.
- Venue
- Science
- Published
- 2013-11-29
- Volume
- 342
- Issue
- 6162
- Pages
- 1090-1094
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064778609
- Cited by
- 398
- References
- 62
- FWCI
- 27.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Kong, L., Giang, E., Nieusma, T., Kadam, R. U., Cogburn, K. E., Hua, Y., Dai, X., Stanfield, R. L., Burton, D. R., Ward, A. B., Wilson, I. A., & Law, M. (2013). Hepatitis C Virus E2 Envelope Glycoprotein Core Structure. Science. https://doi.org/10.1126/science.1243876
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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